Navigation Links
Newly identified proteins make promising targets for blocking graft-vs.-host disease
Date:10/31/2013

The researchers validated their findings in laboratory studies to look at T-cell functions in cell cultures and in mice. Importantly, when they blocked the proteins, it impacted the T-cell function and reduced graft-vs.-host disease in mice.

"We know a lot of proteins play a role in T-cell responses. We're adding more to the armory. Our initial validations in mice are preliminary, but a promising start," says senior study author Pavan Reddy, M.D., professor of hematology/oncology at the U-M Medical School.

This research is still in its early stages. No compounds currently are known to target Wapal or Synj1. Additional research is needed.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
2. Newly discovered ocean plume could be major source of iron
3. Newly discovered switch plays dual role in memory formation
4. Newly discovered bacterial partnership changes ocean chemistry
5. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
6. Newly identified bone marrow stem cells reveal markers for ALS
7. Newly developed medium may be useful for human health, biofuel production, more
8. A newly discovered hormone makes ovaries grow
9. Newly described type of immune cell and T cells share similar path to maturity
10. FRAX newly released as version 3.8 -- Over 5 million online calculations since June 2011
11. Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly identified proteins make promising targets for blocking graft-vs.-host disease
(Date:4/15/2014)... nanoparticle form could help reduce side effects by targeting ... scientists have developed nanoparticles that deliver one or two ... design particles that can carry any more than that ... devised a new way to build such nanoparticles, making ... drugs. In a paper published in the Journal ...
(Date:4/15/2014)... in the Congo Basin to increase by 0.7 ... greenhouse gases by half, according to a study ... , Explosive population growth and inefficient agricultural practices ... Central Africa. A team of researchers from the ... affect longer-term temperatures in the region. Using a ...
(Date:4/15/2014)... systems soon could be powering the forklifts used in ... with faster refueling times than ever before, courtesy of ... Carriers (HHC). , The goal of the project is ... refuel at low pressure four to five times faster ... hydrogen a competitive advantage over batteries for a big ...
Breaking Biology News(10 mins):Targeting cancer with a triple threat 2Targeting cancer with a triple threat 3Study: Deforestation could intensify climate change in Congo Basin by half 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4
... 2010) When researchers tested three different labeling agents ... effect the labeling agents had on stem cell phenotype, ... stem cell proliferation depending on the type of contrast ... and Spain tested USPIO (ultra small superparamagnetic iron oxide) ...
... voracious predatory crabs due to global warming could threaten ... published findings. "King crabs are ecologically important ... fisheries," said Dr Sven Thatje, an evolutionary ecologist at ... Science (SOES), which is based at the National Oceanography ...
... to spot prey, vision keeps many animals, including humans, alive. ... is it easier for us to spot movement of small ... things? The complexity of the neural network that supports vision ... and support from the National Science Foundation, Claire Wyart in ...
Cached Biology News:MRI contrast agents change stem cell proliferation 2King crab distributions limited by temperature in the Southern Ocean 2The zebrafish's neural circuit prevents it from biting off more than it can chew 2
(Date:1/14/2014)... SAN DIEGO and BETHESDA, ... announced today that they are joining together with ... (NIH) to help scientists develop more reliable tools ... on a faster timeline. Organovo is collaborating with ... and the National Eye Institute (NEI) to develop ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation ... discovering, developing and commercializing innovative therapies addressing ... today announced that it received the Notice ... and Trademark Office on its unique self-delivering ... fibrosis. The patent covers the use of ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ... staff,” said Dr. Andrew Brown, SPIE Senior Director for ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ... called WebBytez . WebBytez is a patent-pending way ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... nanotubes as the critical component of a robust terahertz ... and communication devices, sensors and non-invasive medical imaging systems ... systems. The polarizer developed by the Rice lab ... engineering and of physics and astronomy, is the most ...
... (OTCBB: SNGX) (Soligenix or the Company), a development stage ... Amendment to its Amended and Restated Certificate of Incorporation ... stock which will take effect tomorrow morning. ... an opportune time to effect a reverse stock split," ...
...  bioTheranostics, Inc., a bioMerieux company that develops innovative ... introduced a new product line of high medical ... called PRECIS Precision Medicine by bioTheranostics(SM). Precision medicine, ... diagnosis of primary tumor site and predictive biomarkers ...
Cached Biology Technology:Research at Rice University leads to nanotube-based device for communication, security, sensing 2Research at Rice University leads to nanotube-based device for communication, security, sensing 3Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 2Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 3Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 4bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 2bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 3
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
Request Info...
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: