Navigation Links
Newly identified proteins make promising targets for blocking graft-vs.-host disease
Date:10/31/2013

ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified new proteins that control the function of critical immune cell subsets called T-cells, which are responsible for a serious and often deadly side effect of lifesaving bone marrow transplants.

These new proteins have not previously been associated with T-cell responses. T-cells help fight infections but also can trigger autoimmune diseases or graft vs. host disease, a side effect of bone marrow transplant in which the new donor cells begin attacking other cells in the patient's body.

"We identified new targets within the T-cells that regulate the immune response to foreign antigens. If these proteins can be targeted, it may prove helpful in reducing graft-vs.-host disease," says study first author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.

Reducing the incidence of graft-vs.-host disease could make bone marrow transplant an option for more people with blood-based cancers. About half of people who receive a transplant from donated cells develop graft-vs.-host.

In this study, which is published in the Journal of Clinical Investigation, the researchers looked at the landscape of mRNA and micro-RNA after the T-cells were activated by different kinds of stimuli. mRNA are made from the genes present in the DNA and serve as templates for making proteins. Micro-RNA are also copied from the DNA but do not code for proteins; instead they fine tune the expression of other genes and proteins.

By looking at both simultaneously, the researchers were able to tease out only the mRNAs that were regulated by micro-RNA. They found that two mRNA's that express the proteins Wapal and Synj1 were among the most differentially expressed. Both these proteins have been implicated in other cellular functions, but had not previously been linked to a role in T-cell immune responses.

The researchers validated their findings in laboratory studies to look at T-cell functions in cell cultures and in mice. Importantly, when they blocked the proteins, it impacted the T-cell function and reduced graft-vs.-host disease in mice.

"We know a lot of proteins play a role in T-cell responses. We're adding more to the armory. Our initial validations in mice are preliminary, but a promising start," says senior study author Pavan Reddy, M.D., professor of hematology/oncology at the U-M Medical School.

This research is still in its early stages. No compounds currently are known to target Wapal or Synj1. Additional research is needed.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related biology news :

1. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
2. Newly discovered ocean plume could be major source of iron
3. Newly discovered switch plays dual role in memory formation
4. Newly discovered bacterial partnership changes ocean chemistry
5. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
6. Newly identified bone marrow stem cells reveal markers for ALS
7. Newly developed medium may be useful for human health, biofuel production, more
8. A newly discovered hormone makes ovaries grow
9. Newly described type of immune cell and T cells share similar path to maturity
10. FRAX newly released as version 3.8 -- Over 5 million online calculations since June 2011
11. Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly identified proteins make promising targets for blocking graft-vs.-host disease
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Sequenom, Inc. (NASDAQ: ... healthier lives through the development of innovative products and ... the United States denied its petition ... claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") ... established by the Supreme Court,s Mayo Collaborative Services v. ...
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
Breaking Biology Technology: