Navigation Links
Newly identified natural protein blocks HIV, other deadly viruses
Date:2/11/2013

A team of UCLA-led researchers has identified a protein with broad virus-fighting properties that potentially could be used as a weapon against deadly human pathogenic viruses such as HIV, Ebola, Rift Valley Fever, Nipah and others designated "priority pathogens" for national biosecurity purposes by the National Institute of Allergy and Infectious Disease.

In a study published in the January issue of the journal Immunity, the researchers describe the novel antiviral property of the protein, cholesterol-25-hydroxylase (CH25H), an enzyme that converts cholesterol to an oxysterol called 25-hydroxycholesterol (25HC), which can permeate a cell's wall and block a virus from getting in.

Interestingly, the CH25H enzyme is activated by interferon, an essential antiviral cell-signaling protein produced in the body, said lead author Su-Yang Liu, a student in the department of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA.

"Antiviral genes have been hard to apply for therapeutic purposes because it is difficult to express genes in cells," said Liu, who performed the study with principal investigator Genhong Cheng, a professor of microbiology, immunology and molecular genetics. "CH25H, however, produces a natural, soluble oxysterol that can be synthesized and administered.

"Also, our initial studies showing that 25HC can inhibit HIV growth in vivo should prompt further study into membrane-modifying cholesterols that inhibit viruses," he added.

The discovery is particularly relevant to efforts to develop broad-spectrum antivirals against an increasing number of merging viral pathogens, Liu said.

Working with Jerome Zack, a professor of microbiology, immunology and molecular genetics and an associate director of the UCLA AIDS Institute, the researchers initially found that 25HC dramatically inhibited HIV in cell cultures. Next, they administered 25HC in
'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly discovered plant structure may lead to improved biofuel processing
2. Newly discovered scarecrow gene might trigger big boost in food production
3. Newly discovered effects of vitamin D on cancer
4. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
5. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
6. ORNLs newly licensed neutron detector will advance human disease research
7. U of M researchers: Newly discovered genetic markers could signal colon cancer development
8. Newly discovered dinosaur implies greater prevalence of feathers
9. Newly discovered breast milk antibodies help neutralize HIV
10. Key proteins newly discovered form and function may provide novel cancer treatment target
11. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces the second ... is underway to early access pre-order customers. ... at retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, ... was accepted at all outlets and very easy to ...
(Date:4/1/2015)... April 1, 2015   Medisafe ™, the leading ... across iOS and Android smartphones ... biofeedback into the platform to allow patients to track ... the first time, patients will be able to visualize ... impacts important biometrics, such as glucose levels and blood ...
(Date:3/31/2015)...  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant ... Defined Network Architecture (ET Software DNA® 2.0) platforms and ... $20.4 million for the year ended December 31, 2014 ... year ended December 31, 2013. At ... its multi-year transition away from its legacy landline business ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... viruses or parasites attack, immune system cells unleash the ... trigger inflammation, which, if unchecked, can destroy tissue, induce ... let loose another protein compound to cool down the ... operates is unclear. The leading hypothesis is that these ...
... Research Institute (NHGRI), one of the National Institutes ... targets including the Northern white-cheeked gibbon (Nomascus leucogenys), ... sequence the genome of at least one non-human ... along the evolutionary primate tree and making available ...
... The brain's septum helps prevent epileptic seizures by ... another area of the brain known as the ... Journal of Neurophysiology. The researchers found that, by ... rats, they could reduce epileptic seizures by 86-97 ...
Cached Biology News:Research reveals inner workings of immune system 'thermostat' 2NHGRI announces latest sequencing targets 2NHGRI announces latest sequencing targets 3NHGRI announces latest sequencing targets 4NHGRI announces latest sequencing targets 5NHGRI announces latest sequencing targets 6Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 2Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 3
(Date:3/31/2015)...  The Myeloma Crowd Research Initiative (MCRI) completed ... proposals that will now be evaluated for further ... validated funding initiative uncovering solutions for high-risk multiple ... MCRI included preliminary vetting by the Scientific Advisory ... of innovative projects focusing on high-risk myeloma, we ...
(Date:3/31/2015)...  University of Illinois, Swanlund ... plenary session address on Monday, May 18 at the ... kicking off a week of more than 160 technical ... RF and microwave technologies with health. Dr. ... Circuits for the Skin," will focus on the experimental ...
(Date:3/31/2015)... Orlando, Florida (PRWEB) March 31, 2015 ... announced the official relocation of their U.S. facilities and ... more than 25 years of experience, Cryos’ relocation is ... presence. , The move to Orlando was completed during ... with an official opening taking place on April 6. ...
(Date:3/31/2015)... Campbell, California (PRWEB) March 31, 2015 ... management consulting firm with operations in California, Oregon, ... formal launch of its Merger and Acquisition (M&A) ... , Peter Adams, VP Client Services and M&A ... repeatedly shown that the vast majority of M&A ...
Breaking Biology Technology:Myeloma Crowd Research Initiative Selects 10 High-Risk Multiple Myeloma Proposals For Further Review 2Health and Engineering Converge at the 2015 International Microwave Symposium 2Health and Engineering Converge at the 2015 International Microwave Symposium 3Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2Lighthouse Information Systems, Inc., Announces Addition of M&A Integration Services 2
... growth company of diversified businesses, ... Transportation Accessories Group has acquired ... zinc plating services. Chem-Chrome is ... has been a longtime processor ...
... Software, worldwide leader in e-document ... Fax and VSI-FAX(R) product families, ... 3.0. This new solution allows ... more efficiently, effectively, and economically ...
... nanoscale device developed by a University of Wisconsin-Madison Engineering ... electrons in such devices as laptop computers and provide ... This device will allow researchers to study ... heat dissipation on single electron transport in transistors. ...
Cached Biology Technology:Cool Computers 2Cool Computers 3
... to the third cytoplasmic loop of human ... KLH. The immunizing peptide has 79% homology ... Physical form: Solution in phosphate buffered saline, ... Titertest method: IHC (p). Titertest values: ...
... Hot Start Taq ... activity before the onset ... nonspecific amplification and primer-dimer ... is raised, the antibody ...
... Human Pathogenic Viruses The National ... preserves well characterised, authenticated human ... facility, and NCPV is able ... nucleic acids derived from them, ...
... Hex, Tet Cy3, Cy5, Texas Red, ... Hole Quenchers Molecular Beacons* ... 3 Dabcyl Dabcyl*Licensed from the ... labelled probes are purified either by HPLC ...
Biology Products: