Navigation Links
Newly identified natural protein blocks HIV, other deadly viruses
Date:2/11/2013

A team of UCLA-led researchers has identified a protein with broad virus-fighting properties that potentially could be used as a weapon against deadly human pathogenic viruses such as HIV, Ebola, Rift Valley Fever, Nipah and others designated "priority pathogens" for national biosecurity purposes by the National Institute of Allergy and Infectious Disease.

In a study published in the January issue of the journal Immunity, the researchers describe the novel antiviral property of the protein, cholesterol-25-hydroxylase (CH25H), an enzyme that converts cholesterol to an oxysterol called 25-hydroxycholesterol (25HC), which can permeate a cell's wall and block a virus from getting in.

Interestingly, the CH25H enzyme is activated by interferon, an essential antiviral cell-signaling protein produced in the body, said lead author Su-Yang Liu, a student in the department of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA.

"Antiviral genes have been hard to apply for therapeutic purposes because it is difficult to express genes in cells," said Liu, who performed the study with principal investigator Genhong Cheng, a professor of microbiology, immunology and molecular genetics. "CH25H, however, produces a natural, soluble oxysterol that can be synthesized and administered.

"Also, our initial studies showing that 25HC can inhibit HIV growth in vivo should prompt further study into membrane-modifying cholesterols that inhibit viruses," he added.

The discovery is particularly relevant to efforts to develop broad-spectrum antivirals against an increasing number of merging viral pathogens, Liu said.

Working with Jerome Zack, a professor of microbiology, immunology and molecular genetics and an associate director of the UCLA AIDS Institute, the researchers initially found that 25HC dramatically inhibited HIV in cell cultures. Next, they administered 25HC in
'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly discovered plant structure may lead to improved biofuel processing
2. Newly discovered scarecrow gene might trigger big boost in food production
3. Newly discovered effects of vitamin D on cancer
4. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
5. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
6. ORNLs newly licensed neutron detector will advance human disease research
7. U of M researchers: Newly discovered genetic markers could signal colon cancer development
8. Newly discovered dinosaur implies greater prevalence of feathers
9. Newly discovered breast milk antibodies help neutralize HIV
10. Key proteins newly discovered form and function may provide novel cancer treatment target
11. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Carbon dioxide emissions, the main contributor to global warming, are ... high of 40 billion tonnes. , The 2.5 per cent ... Global Carbon Project, which is co-led in the UK by ... the University of East Anglia and the College of Engineering, ... It comes ahead of the New York Climate Summit, where ...
(Date:9/21/2014)... -- Shellfish such as mussels and barnacles secrete very ... ship hulls, even underwater. Inspired by these natural adhesives, ... that could be used to repair ships or help ... new waterproof adhesives, the MIT researchers engineered bacteria to ... proteins as well as a bacterial protein found in ...
(Date:9/19/2014)... study the unique bioelectric signaling system of the electric ... The OU researcher is working to understand how ... signals used to map the world around them. ... 500-600 discharges a second throughout their lives. The ... but necessary for survival. , "There is evidence that ...
Breaking Biology News(10 mins):CO2 emissions set to reach new 40 billion ton record high in 2014 2CO2 emissions set to reach new 40 billion ton record high in 2014 3Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3
... Boston have developed a new nanobiotechnology that enables ... They describe the technology, which could lead to ... January issue of Nature Nanotechnology (published online January ... Mannix, PhD, of Childrens program in Vascular Biology, ...
... transcription -- the intricate transfer of information from a ... RNA -- isn,t stationed in special "transcription factories" within ... enzyme RNA polymerase II (Pol II) and other key ... gene, regardless of the gene,s position., The findings, published ...
... for Biomolecular Sciences (SBS) WHAT: Latest Findings and ... WHEN: April 6-10, 2008 WHERE: SBS ... BACKGROUND: More than 2,500 researchers and professionals ... expected to attend the 14th Annual Conference & Exhibition of ...
Cached Biology News:An 'attractive' man-machine interface 2An 'attractive' man-machine interface 3Research sheds light on the mechanics of gene transcription 2
(Date:9/22/2014)... DUBLIN , Sept. 22, 2014 ... the "Global and Chinese Microcrystalline Cellulose Industry Report ... The Global and Chinese Microcrystalline Cellulose Industry Report 2014 ... state of the global microcrystalline cellulose industry with a ... provides a basic overview of the industry including definitions, ...
(Date:9/22/2014)... Washington, D.C (PRWEB) September 22, 2014 ... the top privately held biotechnology companies of 2014. ... of companies before selecting this year’s winners. Those ... private biotechnology companies in the industry. , ... a new group of Fierce 15 companies," said Carroll. ...
(Date:9/22/2014)... Sept. 22, 2014 Synageva BioPharma ... a biopharmaceutical company developing therapeutic products for rare ... Bazemore as Chief Operating Officer.  Reporting directly ... Chief Executive Officer, Robert will oversee the planned ... sebelipase alfa for LAL Deficiency, and will have ...
(Date:9/21/2014)... Chemical Sciences play a significant role ... air and safe water, healthy food, and dependable ... food scientists, educators, and scientists have a great ... of Chemistry for the national development, and to ... the fastest emerging Sciences, accelerating with a tremendous ...
Breaking Biology Technology:Global and Chinese Microcrystalline Cellulose Industry Report 2014 2FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 3Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 4Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3
... Prepare DNA from blood, cultured cells, or bacteria: , ... boil for 8 min. , ... substrate for PCR amplification. , DNA ... that are frozen, refrigerated, or collected fresh. , 1. Add ...
... , AquaPure Genomic DNA Isolation Kit ... g DNA (15-ml tube prep), , Method ... 1. Add 1 ml body fluid (e.g., cerebrospinal fluid, plasma, saliva, serum, , ... centrifuge , tube containing 5 ml cell lysis solution. Pipet up ...
... , MJ Research, Inc., South San Francisco, CA , ... Abstract , We present a real-time quantitative ... of soy genetically modified to be resistant to the herbicide , ... of the genetically modified organism (GMO) specific sequences as well , ...
Cached Biology Technology:InstaGene Matrix: Prepare DNA Templates for PCR With No Phenol/Chloroform Extractions and No Deproteinization Steps, Rev C 2Genomic DNA Isolation From 1 ml of Body Fluid 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 3Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 4Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 5Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 6Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 7Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 8
FluoSpheres® biotin-labeled microspheres, 0.2 µm, yellow-green fluorescent (505/515) *1% solids*...
GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal Transduction Storage: 4 C...
... Anti-NY-ESO-1, clone E978 ... : NM_001327 Immunogen ... protein Formulation: mouse ascites ... Quality Assurance: routinely evaluated ...
R26.4C...
Biology Products: