Navigation Links
Newly identified growth factor promotes stem cell growth, regeneration
Date:3/21/2010

DURHAM, N.C. -- Scientists at Duke University Medical Center have identified a new growth factor that stimulates the expansion and regeneration of hematopoietic (blood-forming) stem cells in culture and in laboratory animals. The discovery, appearing in the journal Nature Medicine, may help researchers overcome one of the most frustrating barriers to cellular therapy: the fact that stem cells are so few in number and so stubbornly resistant to expansion.

Researchers believe that umbilical cord blood could serve as a universal source of stem cells for all patients who need a stem cell transplant, but the numbers of stem cells in cord blood units are limited, so there is a clinical need to develop a method to expand cord blood stem cells for transplantation purposes. "Unfortunately, there are no soluble growth factors identified to date that have been proven to expand human stem cells for therapeutic purposes," said John Chute, M.D., a stem cell transplant physician and cell biologist at Duke and senior author of the paper.

Chute, working with Heather Himburg, a post-doctoral fellow in his laboratory, discovered that adding pleiotrophin, a naturally-occurring growth factor, stimulated a ten-fold expansion of stem cells taken from the bone marrow of a mouse.

They also found that pleiotrophin increased the numbers of human cord blood stem cells in culture that were capable of engraftment in immune-deficient mice. When they injected pleiotrophin into mice that had received bone marrow-suppressive radiation, they observed a 10-fold increase in bone marrow stem cells compared to untreated mice. "These results confirmed that pleiotrophin induces stem cell regeneration following injury," said Chute.

Chute says the finding could lead to broader application of cord blood transplants for the large numbers of patients who do not have an immune-matched donor "Perhaps more importantly, systemic treatment with pleiotrophin may have the potential to accelerate recovery of the blood and immune system in patients undergoing chemotherapy or radiotherapy," he said.

Given the potency of the effect of pleiotrophin on stem cell expansion, the authors examined whether pleiotrophin provoked blood-forming cells to become malignant. So far, Chute says they have not seen any evidence of cancer in mice up to six months after treatment with pleiotrophin.

The Duke team is already conducting further experiments to determine if pleiotrophin is necessary for normal stem cell growth and development, and Chute says it will be important to conduct additional animal studies before moving into human clinical trials. "At this point, any progress we can make that helps us better understand which biological pathways are activated in stem cells in response to pleiotrophin will help move the discovery forward."


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. MSU scientists unlock key enzyme using newly created cool method
2. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
3. Newly identified enzymes help plants sense elevated CO2 and could lead to water-wise crops
4. Newly discovered mechanism allows cells to change state
5. Newly discovered fat molecule: An undersea killer with an upside
6. Newly found DNA catalysts cleave DNA with water molecule
7. Newly discovered gene fusion may lead to improved prostate cancer diagnosis
8. Newly discovered snow roots are evolutionary phenomenon
9. Newly discovered reactions from an old drug may lead to new antibiotics
10. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
11. Newly discovered gene plays vital role in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/16/2017)... --  Bridge Patient Portal , an enterprise patient ... Systems , an electronic medical record solutions developer ... a partnership to build an interface between the ... products, including Centricity Practice Solution (CPS), Centricity Business ... integrations will allow healthcare delivery networks using GE ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... ... July 13, 2017 , ... Dr. Joshua Mondlick has introduced the LANAP® protocol ... Mondlick Perio, in the Phoenix area. Dr. Mondlick is at the forefront ... cleared laser treatment to re-grow bone and with significantly less pain than traditional surgery ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... Thousands of ... and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to compete ... to earn spots on US teams that participate in world championships. , RC Pylon ...
(Date:7/13/2017)... , ... July 13, 2017 , ... ... two spectrophotometer calibration standards. Blast forward seven years and now they are ... holmium oxide for wavelength accuracy, and resolution testing. , ...
(Date:7/13/2017)... ... July 13, 2017 , ... Trinity Sterile, ... reusable medical supplies has chosen The Copley Consulting Group to implement and deploy ... to align its internal and backend operations to streamline efficiencies to meet the ...
Breaking Biology Technology: