Navigation Links
Newly identified growth factor promotes stem cell growth, regeneration
Date:3/21/2010

DURHAM, N.C. -- Scientists at Duke University Medical Center have identified a new growth factor that stimulates the expansion and regeneration of hematopoietic (blood-forming) stem cells in culture and in laboratory animals. The discovery, appearing in the journal Nature Medicine, may help researchers overcome one of the most frustrating barriers to cellular therapy: the fact that stem cells are so few in number and so stubbornly resistant to expansion.

Researchers believe that umbilical cord blood could serve as a universal source of stem cells for all patients who need a stem cell transplant, but the numbers of stem cells in cord blood units are limited, so there is a clinical need to develop a method to expand cord blood stem cells for transplantation purposes. "Unfortunately, there are no soluble growth factors identified to date that have been proven to expand human stem cells for therapeutic purposes," said John Chute, M.D., a stem cell transplant physician and cell biologist at Duke and senior author of the paper.

Chute, working with Heather Himburg, a post-doctoral fellow in his laboratory, discovered that adding pleiotrophin, a naturally-occurring growth factor, stimulated a ten-fold expansion of stem cells taken from the bone marrow of a mouse.

They also found that pleiotrophin increased the numbers of human cord blood stem cells in culture that were capable of engraftment in immune-deficient mice. When they injected pleiotrophin into mice that had received bone marrow-suppressive radiation, they observed a 10-fold increase in bone marrow stem cells compared to untreated mice. "These results confirmed that pleiotrophin induces stem cell regeneration following injury," said Chute.

Chute says the finding could lead to broader application of cord blood transplants for the large numbers of patients who do not have an immune-matched donor "Perhaps more importantly, systemic treatment with pleiotrophin may have the potential to accelerate recovery of the blood and immune system in patients undergoing chemotherapy or radiotherapy," he said.

Given the potency of the effect of pleiotrophin on stem cell expansion, the authors examined whether pleiotrophin provoked blood-forming cells to become malignant. So far, Chute says they have not seen any evidence of cancer in mice up to six months after treatment with pleiotrophin.

The Duke team is already conducting further experiments to determine if pleiotrophin is necessary for normal stem cell growth and development, and Chute says it will be important to conduct additional animal studies before moving into human clinical trials. "At this point, any progress we can make that helps us better understand which biological pathways are activated in stem cells in response to pleiotrophin will help move the discovery forward."


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. MSU scientists unlock key enzyme using newly created cool method
2. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
3. Newly identified enzymes help plants sense elevated CO2 and could lead to water-wise crops
4. Newly discovered mechanism allows cells to change state
5. Newly discovered fat molecule: An undersea killer with an upside
6. Newly found DNA catalysts cleave DNA with water molecule
7. Newly discovered gene fusion may lead to improved prostate cancer diagnosis
8. Newly discovered snow roots are evolutionary phenomenon
9. Newly discovered reactions from an old drug may lead to new antibiotics
10. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
11. Newly discovered gene plays vital role in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... January 12, 2017 A new report by Allied Market Research, ... global biometric technology market is expected to generate revenue of $10.72 billion by 2022, ... Continue Reading ... Allied Market Research Logo ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) In ...
(Date:1/6/2017)... 2017  SomaLogic announced today that it has ... by iCarbonX, the China -based ... Digital Health Ecosystem that can define each person,s ... biological, behavioral and psychological data, the Internet and ... SomaLogic will provide proteomics data and applications expertise ...
(Date:1/3/2017)... , Jan. 3, 2017 Onitor, provider of ... of Onitor Track, an innovative biometric data-driven program designed ... this month at the 2017 Consumer Electronics Show (CES) ... In the U.S., the World Health Organization (WHO), ... two-thirds of adults who are overweight or obese. WHO ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... South Jordan, Utah (PRWEB) , ... January 23, 2017 , ... ... solution has been named an INTERNET TELEPHONY Product of the Year Award winner for ... as an industry leader in unified communications solutions. In 2016, CallTower was awarded with ...
(Date:1/21/2017)... , Jan. 20, 2017 Bioptix, ... the "Company"), announced that on January 14, 2017 the ... under which the Company will terminate certain employees associated ... Diagnostics, Inc.  The Company commenced terminations on January 16, ... 30 days.  The Company may pay severance benefits in ...
(Date:1/20/2017)... 2017 Ginkgo Bioworks, the organism company, ... in the synthesis and assembly of DNA. The ... pathway-length synthetic DNA into Ginkgo,s automated organism engineering ... construction of new organism designs for application across ... was founded to significantly increase the world,s capacity ...
(Date:1/19/2017)... HOUSTON , Jan. 19, 2017 /PRNewswire/ ... the formation of its Medical/Clinical Advisory Board.  This ... veterans who enhance the range and depth of ... of its novel prenatal diagnostic tests.  These experts ... strategic guidance for the company,s product development and ...
Breaking Biology Technology: