Navigation Links
Newly-identified exercise gene could help with depression
Date:12/2/2007

New Haven, Conn.Boosting an exercise-related gene in the brain works as a powerful anti-depressant in micea finding that could lead to a new anti-depressant drug target, according to a Yale School of Medicine report in Nature Medicine.

The VGF exercise-related gene and target for drug development could be even better than chemical antidepressants because it is already present in the brain, said Ronald Duman, professor of psychiatry and senior author of the study.

Depression affects 16 percent of the population in the United States, at a related cost of $83 billion each year. Currently available anti-depressants help 65 percent of patients and require weeks to months before the patients experience relief.

Duman said it is known that exercise improves brain function and mental health, and provides protective benefits in the event of a brain injury or disease, but how this all happens in the brain is not well understood. He said the fact that existing medications take so long to work indicates that some neuronal adaptation or plasticity is needed.

He and his colleagues designed a custom microarray that was optimized to show small changes in gene expression, particularly in the brains hippocampus, a limbic structure highly sensitive to stress hormones, depression, and anti-depressants.

They then compared the brain activity of sedentary mice to those who were given running wheels. The researchers observed that the mice with wheels within one week were running more than six miles each night. Four independent array analyses of the mice turned up 33 hippocampal exercise-regulated genes27 of which had never been identified before.

The action of one gene in particularVGFwas greatly enhanced by exercise. Moreover, administering VGF functioned like a powerful anti-depressant, while blocking VGF inhibited the effects of exercise and induced depressive-like behavior in the mice.

Identification of VGF provides a mechanism by which exercise produces antidepressant effects, Duman said. This information further supports the benefits of exercise and provides a novel target for the development of new antidepressants with a completely different mechanism of action than existing medications.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. Obesity and lack of exercise could enhance the risk of pancreatic cancer
2. Exercise improves thinking, reduces diabetes risk in overweight children
3. Canadian Society of Exercise Physiology Annual Scientific Conference
4. Newly created cancer stem cells could aid breast cancer research
5. Finding that 1-in-a-billion that could lead to disease
6. 60 second test could help early diagnosis of common brain diseases
7. Auto immune response creates barrier to fertility; could be a step in speciation
8. Paracetamol, one of most used analgesics, could slow down bone growth
9. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
10. Thousands of starving children could be restored to health with peanut butter program
11. Nanotech could make solar energy as easy and cheap as growing grass
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... N.C. (PRWEB) , ... October 11, 2017 , ... ... ARCS® Foundation President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, ... ( ASTER Labs ), Inc. has been selected for membership in ARCS ...
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
Breaking Biology Technology: