Navigation Links
Newly-identified exercise gene could help with depression
Date:12/2/2007

New Haven, Conn.Boosting an exercise-related gene in the brain works as a powerful anti-depressant in micea finding that could lead to a new anti-depressant drug target, according to a Yale School of Medicine report in Nature Medicine.

The VGF exercise-related gene and target for drug development could be even better than chemical antidepressants because it is already present in the brain, said Ronald Duman, professor of psychiatry and senior author of the study.

Depression affects 16 percent of the population in the United States, at a related cost of $83 billion each year. Currently available anti-depressants help 65 percent of patients and require weeks to months before the patients experience relief.

Duman said it is known that exercise improves brain function and mental health, and provides protective benefits in the event of a brain injury or disease, but how this all happens in the brain is not well understood. He said the fact that existing medications take so long to work indicates that some neuronal adaptation or plasticity is needed.

He and his colleagues designed a custom microarray that was optimized to show small changes in gene expression, particularly in the brains hippocampus, a limbic structure highly sensitive to stress hormones, depression, and anti-depressants.

They then compared the brain activity of sedentary mice to those who were given running wheels. The researchers observed that the mice with wheels within one week were running more than six miles each night. Four independent array analyses of the mice turned up 33 hippocampal exercise-regulated genes27 of which had never been identified before.

The action of one gene in particularVGFwas greatly enhanced by exercise. Moreover, administering VGF functioned like a powerful anti-depressant, while blocking VGF inhibited the effects of exercise and induced depressive-like behavior in the mice.

Identification of VGF provides a mechanism by which exercise produces antidepressant effects, Duman said. This information further supports the benefits of exercise and provides a novel target for the development of new antidepressants with a completely different mechanism of action than existing medications.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. Obesity and lack of exercise could enhance the risk of pancreatic cancer
2. Exercise improves thinking, reduces diabetes risk in overweight children
3. Canadian Society of Exercise Physiology Annual Scientific Conference
4. Newly created cancer stem cells could aid breast cancer research
5. Finding that 1-in-a-billion that could lead to disease
6. 60 second test could help early diagnosis of common brain diseases
7. Auto immune response creates barrier to fertility; could be a step in speciation
8. Paracetamol, one of most used analgesics, could slow down bone growth
9. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
10. Thousands of starving children could be restored to health with peanut butter program
11. Nanotech could make solar energy as easy and cheap as growing grass
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
(Date:1/22/2016)... , January 22, 2016 ... the addition of the  "Global Behavioral ... offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ... "Global Behavioral Biometric Market 2016-2020"  report ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ...
(Date:1/20/2016)... -- A market that just keeps on growing. Molecular ... in genomics knowledge. Learn all about it in this ... dynamic trends are pushing market growth and company valuations. ... - pathogen evolution - next generation sequencing - emergence ... of the role of genetic material in Disease and ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... 2016  PTC Therapeutics, Inc. (NASDAQ: PTCT ... to Realize Innovation, Vision and Empowerment) grant award ... funds to patient advocacy organizations to develop unique ... to the rare disease community by increasing awareness, ... advocates. Mary Frances Harmon , ...
(Date:2/11/2016)... 11, 2016  Vermillion, Inc. (NASDAQ: VRML ), ... announced the formation of the Steering Committee for its ... --> Pelvic masses can present physicians and ... Once pregnancy is ruled out, pelvic masses may include ... endometriosis, benign ovarian tumors and gastrointestinal and urinary tract ...
(Date:2/11/2016)...  Wellcentive today announced it has been selected ... -based community care organization (CCO) with more than ... reporting and care management solutions and services. Wellcentive,s ... quality managers, analysts and care managers while providing ... FamilyCare members. Oregon ...
(Date:2/11/2016)... , Feb. 11, 2016   BioInformant announces ... "Stem Cell Research Products, Opportunities, Tools, and Technologies – ... The ... the stem cell industry, BioInformant has more than a ... stem cell market, by stem cell type. This powerful ...
Breaking Biology Technology: