Navigation Links
Newly identified bone marrow stem cells reveal markers for ALS
Date:7/9/2013

Amyotrophic Lateral Sclerosis (ALS) is a devastating motor neuron disease that rapidly atrophies the muscles, leading to complete paralysis. Despite its high profile established when it afflicted the New York Yankees' Lou Gehrig ALS remains a disease that scientists are unable to predict, prevent, or cure.

Although several genetic ALS mutations have been identified, they only apply to a small number of cases. The ongoing challenge is to identify the mechanisms behind the non-genetic form of the disease and draw useful comparisons with the genetic forms.

Now, using samples of stem cells derived from the bone marrow of non-genetic ALS patients, Prof. Miguel Weil of Tel Aviv University's Laboratory for Neurodegenerative Diseases and Personalized Medicine in the Department of Cell Research and Immunology and his team of researchers have uncovered four different biomarkers that characterize the non-genetic form of the disease. Each sample shows similar biological abnormalities to four specific genes, and further research could reveal additional commonalities. "Because these genes and their functions are already known, they give us a specific direction for research into non-genetic ALS diagnostics and therapeutics," Prof. Weil says. His initial findings were reported in the journal Disease Markers.

Giving in to stress

To hunt for these biomarkers, Prof. Weil and his colleagues turned to samples of bone marrow collected from ALS patients. Though more difficult to collect than blood, bone marrow's stem cells are easy to isolate and grow in a consistent manner. In the lab, he used these cells as cellular models for the disease. He ultimately discovered that cells from different ALS patients shared the same abnormal characteristics of four different genes that may act as biomarkers of the disease. And because the characteristics appear in tissues that are related to ALS including in muscle, brain, and spinal cord tissu
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly developed medium may be useful for human health, biofuel production, more
2. A newly discovered hormone makes ovaries grow
3. Newly described type of immune cell and T cells share similar path to maturity
4. FRAX newly released as version 3.8 -- Over 5 million online calculations since June 2011
5. Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight
6. Soils in newly forested areas store substantial carbon that could help offset climate change
7. Logging debris gives newly planted Douglas-fir forests a leg-up
8. Newly identified natural protein blocks HIV, other deadly viruses
9. Newly discovered plant structure may lead to improved biofuel processing
10. Newly discovered scarecrow gene might trigger big boost in food production
11. Newly discovered effects of vitamin D on cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... one of the most fundamental processes in the life of ... according to University of Leeds researchers. Arabidopsis thaliana ... cracks in pavements all over Europe and Asia, but the ... rat of the plant world. It has become the ...
... The National Institutes of Health has renewed its ... the Scripps Translational Science Institute (STSI) in the ... years to support innovative research in genomics, wireless ... which is a collaborative program between Scripps Health ...
... In the dog days of summer, female edible dormice ( ... immediately after this energy-intensive period they start to replenish their ... habit seems to give the animals a pleasant taste and ... Romans even kept them in captivity to fatten them up ...
Cached Biology News:Model plant misled scientists about multicellular growth 2Model plant misled scientists about multicellular growth 3NIH awards Scripps Translational Science Institute $29 million grant 2NIH awards Scripps Translational Science Institute $29 million grant 3Fat and fit 2
(Date:12/19/2014)... 18, 2014 Egenix, Inc. is pleased to announce ... of the Board, to succeed Donald Fresne ; Mr. ... continue as a member of the Board.  In recognition of ... the company over almost twenty years, the Board designated Mr. ... Directors has established a Search Committee to find a suitable ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... 17, 2014 Achim Noack has been ... Stoller Group. In this position, Noack will assist Jerry ... matters, develop marketing strategy and supervise global marketing management ... “Achim has tremendous knowledge and experience in the crop ... “His experience and innovative thinking will be a great ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
Breaking Biology Technology:Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 22020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,(TSX: ONC, NASDAQ: ONCY) ... of the Tom Baker Cancer Centre, Calgary, entitled,"Targeting ... at the American Association for Cancer Research (AACR) ... Diego, California from April,12-16, 2008., The presentation ...
... Amylin Pharmaceuticals,Inc. (Nasdaq: AMLN ) will webcast ... 2008 on Monday, April 21, 2008 at 8:30 a.m. ... Executive,Officer, will lead the call. On the same date ... of 2008., The call will be webcast live ...
... Families, EMERYVILLE, Calif., April 15 Alta ... new health care areas designed to,soothe patients and ... offer health resources. The Carol Ann,Read Breast Health ... all in one location, for the quickest turnaround ...
Cached Biology Technology:Oncolytics Biotech Inc. Collaborators Present Reovirus Research for Multiple Myeloma at AACR Annual Meeting 2Amylin Pharmaceuticals to Webcast First Quarter Results 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 3
... The BAS-2500 is ... applications: Molecular Biology (1D ... protein blots, Macroarrays); Pharmacokinetics ... autoradiography, thin layer chromatography); ...
... This microscope is described by end-users ... it incorporates the fundamentals of light microscopy ... and small footprint, it does not require ... in a busy lab environment. The DM-BA300 ...
... BAS-5000 is the highest resolution standard ... top member of Fujifilm's family of ... Imaging Plate (IP) and changeable resolutions ... Fujifilm BAS-5000 does it without compromising ...
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
Biology Products: