Navigation Links
Newly identified DNA repair defect linked to increased risk of leukemia relapse
Date:9/26/2011

r work from the laboratory of Evans and others that linked a deficit of MSH2 with an increased risk of certain cancers and resistance to mercaptopurine, a drug that is the backbone of leukemia treatment.

In this study, scientists found that 11 percent of 90 newly diagnosed pediatric ALL patients had low or undetectable levels of the MSH2 protein.

Ten years after an ALL diagnosis, children with low MSH2 protein levels were less likely to be alive and four times more likely to have suffered relapses. The comparison included 97 patients treated in a St. Jude study called Total XV, which ended in 2007. Sixteen patients had leukemia with low MSH2 levels. The analysis took other factors into account, including a patient's age and early treatment response, which are associated with high-risk ALL. The results suggest MSH2 protein levels might help identify a new group of high-risk patients.

Further work revealed no evidence of problems in the MSH2 gene itself, so scientists expanded their search for why some patients had low MSH2 levels in their leukemia cells. Researchers looked for changes in the makeup of eight genes known or suspected of playing a role in the breakdown of MSH2. To do that, they screened DNA from 69 of the 90 newly diagnosed ALL patients at nearly 1 million spots in the genome.

The research showed each patient was missing at least one of the four genes that regulate MSH2 degradation. "MSH2 was still made, but the system to protect it from destruction had been impaired or eliminated, leading to more rapid breakdown of MSH2 and a crippled system for fixing DNA," Evans said. The missing genes were FRAP1, HERC1, PRKCZ and PIK3C2B.

A check of leukemia cells from another group of St. Jude ALL patients found that about 12 percent, or 21 of the 170 children, were missing at least one of the same genes. A search of public databases found one or more of the same genes deleted in 13.5 percent of sporadic colorectal canc
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
2. Newly identified gene powerful predictor of colon cancer metastasis
3. Newly found enzymes may play early role in cancer
4. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
5. UC Davis research shows that newly discovered drug reduces heart enlargement
6. Newly described contaminant sources in Katrina-flooded homes pose health risks
7. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
8. Newly discovered gene plays vital role in cancer
9. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
10. Newly discovered reactions from an old drug may lead to new antibiotics
11. Newly discovered snow roots are evolutionary phenomenon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... honeybees in Europe, Asia and the United States are ... be impacting native honeybee populations at this time, according ... include including Nosema microsporidia and Varroa ... resilient to these invasive pests, which suggests to us ... Asia and the United States currently are not necessary ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
(Date:4/17/2014)... the University of Texas Medical Branch at Galveston ... treated with radiation for cervical cancer should begin ... , The UTMB researchers, finding a high incidence ... treated with radiation, offer new recommendations that the ... screening about eight years after their initial cervical ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Radiation therapy for cervical cancer increases risk for colorectal cancer 2
... Permanently Disposes Magnetically Recorded Data to Help QSGI,s ... Calif., Feb. 18 Fujitsu Computer Products of ... products including hard disk drives, peripherals and biometric ... using the Fujitsu Mag EraSURE degaussing ...
... In late 2007, hundreds of dead and stranded seabirds ... feathers saturated with water and coated with an unknown ... massive "red tide" bloom of marine algae had produced ... from the birds, feathers. This is the ...
... French . , Montreal, February 20, 2009 ... birds, and provides clues that can be applied across the ... Biology Letters , shows that Herring and Ring-billed gulls ... to assure their survival. Contrary to previous beliefs, this study ...
Cached Biology News:QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 2QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 3QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 4QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 5Study links seabird deaths to soap-like foam produced by red-tide algae 2Study finds life-saving trend among seagulls 2
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
(Date:1/14/2014)... During the 1600’s through the 1800’s doctors contributed unknowingly ... this time period, doctors did not know that they needed ... death of vulnerable patients. In the same way, medical interns ... unwittingly transmitting herpes viruses to their patients. The CBCD explains. ...
(Date:1/14/2014)... 2014 Holloway America today announced an ... test reports (MTRs) for all pressure vessels and tank ... is particularly important for equipment that must meet ASME, ... features search functionality that allows authorized users to quickly ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 2Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 3
... the leading,manufacturer of specialized graphics solutions, confirms that ... controller boards with its,ME/CCL medical LCD displays., ... single-slot board with,all-digital, triple-monitor output and the flexibility ... resolutions from <1MP to,8MP with up to 1GB ...
... that included numerous medications, trips to the emergency room and surgery to ... Unit at an Ohio hospital. Both sides of his heart were dying ... ... TUCSON, Ariz. (Business Wire EON) October 8, 2008 -- "I swelled ...
... transport and ... storage of purified DNA, ... room temperature biosample management, announces the launch,of an innovative new ... built-in oxidative protection and,antimicrobial activity for dry, room temperature transport ...
Cached Biology Technology:Totoku Europe Chooses Matrox Xenia(TM) Series to Drive Medical Monitors 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest&#8482; temporary Total Artificial Heart 2GenVault Corporation Launches GenTegra(TM) DNA 2GenVault Corporation Launches GenTegra(TM) DNA 3
... culture or fermentation is the ability to ... make rapid adjustments in response to changes ... provide immediate analysis of key nutrients, metabolites, ... media. BioProfile analyzers are fully automated, multi-test ...
... AAIPharmas Routine Testing Laboratory (RTL) ... developed over 25 years. ,,Microbial method ... used to monitor the conditions of ... quality for manufactured products,,We offer a ...
... sequence corresponds to residues 115-133 of rat SAP97. The sequence ... L - P - S - E - R - I ... N - E - V - L - G - P ... conjugation and is not a part of the native rat SAP97 ...
... for which no antibody exists? Having difficulty generating ... a variety of pharmaceutical, biotech and academic researchers ... technology and expertise in antibody generation to work ... RabMAb development technology , High affinity and high ...
Biology Products: