Navigation Links
Newly identified DNA repair defect linked to increased risk of leukemia relapse
Date:9/26/2011

A newly identified defect in a DNA repair system might leave some young leukemia patients less likely to benefit from a key chemotherapy drug, possibly putting them at greater risk of relapse. The problem was identified in a study led by St. Jude Children's Research Hospital scientists.

The study's findings offer a potential new marker to help identify acute lymphoblastic leukemia (ALL) patients who are at higher risk of having their cancer return and thus are candidates for more tailored therapies. The research was published in the September 25 online edition of the scientific journal Nature Medicine.

The work focused on a protein named MSH2, which is involved in DNA repair. DNA is the molecule that carries instructions for building and sustaining life. Cell division requires DNA synthesis. The DNA repair system helps correct errors in DNA production. The DNA repair proteins are also involved in how some chemotherapy agents kill leukemia cells.

In this study, investigators discovered a new mechanism responsible for low MSH2 levels in about 11 percent of pediatric ALL and in several adult cancers. Researchers also found low MSH2 levels were associated with leukemia resistance to the thiopurine medications, including mercaptopurine, a drug all children with ALL receive.

"If confirmed, this work suggests a patient's MSH2 status might someday be used to guide treatment," said Barthelemy Diouf, Ph.D., the first author. He is a postdoctoral fellow in the laboratory of William Evans, Pharm.D., the paper's senior author. Evans is chief executive officer and director of St. Jude.

In the U.S., ALL is diagnosed in about 3,000 children annually, making it the nation's most common childhood cancer. It is also one of modern medicine's success stories. At St. Jude, 90 percent of young ALL patients are now cured. This study reflects ongoing efforts to understand why treatment sometimes fails.

The research built on earlie
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
2. Newly identified gene powerful predictor of colon cancer metastasis
3. Newly found enzymes may play early role in cancer
4. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
5. UC Davis research shows that newly discovered drug reduces heart enlargement
6. Newly described contaminant sources in Katrina-flooded homes pose health risks
7. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
8. Newly discovered gene plays vital role in cancer
9. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
10. Newly discovered reactions from an old drug may lead to new antibiotics
11. Newly discovered snow roots are evolutionary phenomenon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... In this fascinating journey to the edge of science, ... new book The Beginning and the End: Does our ... it cyclic? Are we alone in the universe? What ... cosmic evolution? Grounded in science and committed to philosophical ... rise of intelligent life is not an accident, but ...
(Date:7/29/2014)... territory of Ascension Island, one of the world,s largest ... , Writing in the journal Biodiversity and Conservation ... Island Government Conservation Department report that the number of ... has increased by more than 500 per cent since ... nests are now estimated to be laid on the ...
(Date:7/29/2014)... YORK , July 29, 2014  When it comes to ... new devices, if not the last. However, when it comes to ... Though the market for the Internet of Things and its ... make an impact in the healthcare industry, whether it,s in the ... to keep us fit. With that in mind, InformationWeek ...
Breaking Biology News(10 mins):Book: 'The Beginning and the End' 2Major turtle nesting beaches protected in 1 of the UK's far flung overseas territories 2
... graduate students have won $10,000 from the Dow ... solutions to some of the world,s most urgent ... one of a select number of universities that ... Dow Chemical Co. in 2009. The other schools ...
... but with major injuries, it needs help. That,s when implants ... on titanium, degradable implants are intended to replace the missing ... That may last months or even years, depending on the ... the patient. A new implant improves the conditions for the ...
... the atmosphere rise, policy makers and scientists are looking ... the greenhouse gas. One method under ... known as carbon sequestration. CCS, a newly developing technology, ... the Earth,s atmosphere. Donald J. DePaolo, ...
Cached Biology News:Tufts graduate students win $10,000 prizes 2Bone replacement from laser melting 2
(Date:7/30/2014)... 2014 Adding to their already extensive ... special – Buy 2 of any Weighing Boats ... benefit lab technicians looking for durable and reliable weighing ... for multiple applications including weighing liquids, solid, or granulated ... including diamond-shaped, hexagonal, square, aluminum weighing, and standard boats. ...
(Date:7/29/2014)... Dallas, Texas (PRWEB) July 30, 2014 ... in Private Equity and Venture Capital Funding” report ... factors shaping the private equity and venture capital ... that these are expected to have significant impact ... the US and globally. Furthermore, the report identifies ...
(Date:7/29/2014)... Human Longevity, Inc. (HLI), a genomics and ... the healthy, high performance human life span, today announced ... expert in machine learning and machine translation as the ... Google where he was Distinguished Research Scientist and the ... HLI Co-Founder and CEO, J. Craig Venter , ...
(Date:7/29/2014)... Md. , July 29, 2014  The ... a new and updated program for the 9 ... – 12, 2014 in Amelia Island , ... sites and investigators remains unchanged, however, the topics ... exchange and networking opportunity among all stakeholders with ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3
... , , BASKING RIDGE, N.J., Sept. 4 ... of antithrombotic aptamers with active control agents, announced today that ... Officer, will be presenting at the Thomas Weisel Partners ... Friday, September 11, 2009 (EDT). Ms. McDonald,s presentation ...
... 4 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NYSE: ... announced today that,the Ministry of Industry and Information Technology ... order to Sinovac to purchase H1N1 vaccine for,the national ... to complete the production of 3.3 million doses of ...
... Sept. 4 Palatin Technologies, Inc. (NYSE Amex: PTN ) ... Tuesday, September 8, 2009, before the open of the U.S. financial markets. ... and live audio webcast hosted by its executive management team on September ... greater detail and an update on corporate developments. , , ...
Cached Biology Technology:Regado Biosciences to Present at the Thomas Weisel Partners Healthcare Conference 2009 on September 11, 2009 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 3Palatin Technologies, Inc. to Report Fourth Quarter and Fiscal Year 2009 Results; Teleconference and Webcast to be held on September 8, 2009 2
... The Biomek FX provides ... analysis applications. With 96-, ... pipetting heads in either single ... Biomek FX offers maximum speed ...
... Use in any standard fixed-angle microcentrifuge ... g.,Spin- centrifuge tube filters consist ... a centrifuge tube. They filter by ... HPLC sample preparation, removal of cells ...
... The GenomeLab GeXP Genetic Analysis System ... scalable, multiplexed PCR*. The systems patented ... standard multiplexed PCR analysis to just a ... GeXP delivers more genes per reaction and ...
... The Chemicon Detergent-OUT Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... The Med column is suitable for ...
Biology Products: