Navigation Links
Newly identified B-cell selection process adds to understanding of antibody diversity
Date:6/9/2014

BOSTON As elite soldiers of the body's immune response, B cells serve as a vast standing army ready to recognize and destroy invading antigens, including infections and cancer cells. To do so, each new B cell comes equipped with its own highly specialized weapon, a unique antibody protein that selectively binds to specific parts of the antigen. The key to this specialization is the antigen-binding region that tailors each B cell to a particular antigen, determining whether B cells survive boot camp and are selected for maturation and survival, or wash out and die.

Now, using high-throughput sequencing technology and computational and systems biology, investigators from Beth Israel Deaconess Medical Center (BIDMC) have discovered that B cells can be selected for survival independent of their antigen binding regions. Described online this week in the journal Proceedings of the National Academy of Sciences (PNAS), the findings add a surprising new dimension to the understanding of antibody repertoires each individual's complement of millions of B cells -- and the potential for shaping these repertoires to better fight disease.

"B cells play essential roles in vaccination, infection, autoimmunity, aging and cancer," explains senior author Ramy Arnaout, MD, DPhil, an investigator in the Department of Pathology at BIDMC and Assistant Professor of Pathology at Harvard Medical School whose work focuses on the emerging field of high-throughput multimodality immunology, also known as immunomics. "We were surprised and excited to find that B cell survival could be influenced by a non-antigen-binding region of the antibody, specifically the 'elbow' region that connects the antigen-binding regions to the signaling domain."

Each new B cell makes its own unique antibody by mixing and matching from a set of a few hundred genes, taking one each from subsets called V, D and J. The most diverse part of an antibody is the region where th
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly identified brain cancer mutation will aid drug development
2. Newly found dinosaur is long-nosed cousin of Tyrannosaurus rex
3. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
4. Newly identified small-RNA pathway defends genome against the enemy within
5. Newly discovered catalyst could lead to the low-cost production of clean methanol
6. Newly discovered marsupial the victim of fatal attraction
7. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
8. Newly discovered human peptide may become a new treatment for diabetes
9. Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action
10. Newly identified proteins make promising targets for blocking graft-vs.-host disease
11. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial Services ... in the Health and Fitness Industry, today announced ... to MYiCLUBonline.  The latest upgrade includes advances to ... of cardless check-in via Identity One fingerprint biometrics. ... time through interactive displays at the International Health, ...
(Date:2/19/2015)... Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ... "Military Electro-Optical / Infrared Systems Market by Type, ... Forecast to 2020" report to their offering. ... is expected to reach $16.35 billion by 2020, ... This report segments the military electro-optical/infrared systems market ...
(Date:2/11/2015)... 11, 2015 According ... Control Market by Product (Cards and Readers, Biometrics, Controllers, ... Government, Industrial, Healthcare, Education) and By Geography - Global Forecast and ... the Access Control Market is expected to ... a CAGR of 10.6% between 2014 and ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... movementfrom the blink of an eye to running a marathonnerve ... cells rely on tiny molecular motors to transport chemical messengers ... process, which scientists are still trying to understand. A new ... of the puzzle. The study, published in the April ...
... in French . Montreal, May 25, 2011 ... do it, too. But when it comes to securing a mate ... A group of scientists from Simon Fraser University, Concordia ... the key to reproductive success when males outnumber females. The ...
... been tracked inside a living human cell and may lead ... Professor Lloyd Hollenberg from the University of Melbourne,s School ... first time a single atom encased in nanodiamond has been ... a living human cell. "It is exciting to see ...
Cached Biology News:Syracuse University scientists discover new hitch to link nerve cell motors to their cargo 2Mating rivalry among furred and feathered: Variety is spice of life 2Quantum sensor tracked in human cells could aid drug discovery 2
(Date:2/26/2015)... N.J. , Feb. 26, 2015 On ... and its affiliated companies, Wilentz, Goldman & Spitzer, ... trade secrets lawsuit against Genewiz Inc. in excess of ... and utilized GenScript,s trade secrets, and that it improperly ... entered an order denying motions for judgment notwithstanding the ...
(Date:2/26/2015)... Synageva BioPharma Corp. (NASDAQ: GEVA ... rare disorders, today reported 2014 full year financial ... and financial guidance.  Synageva,s management team will host ... to review the financial results and provide a ... by telephone, please dial (877) 445-4603 for U.S. ...
(Date:2/26/2015)... DuPont Executive Vice President James C. ... advancements and product launches across the Agriculture and Nutrition ... Lynch 2015 Global Agriculture Conference. "While ... the last two years, long-term demand for agricultural production ... last decade, when demand for corn and soybeans increased ...
(Date:2/26/2015)... 2015  NuGene International, Inc. ("NuGene") (OTCQB: NUGN), ... and hair rejuvenation, has announced that it has ... for investor relations and strategic communications. ... and diversification strategies – and we need to ... stated Ali Kharazmi CEO of NuGene when announcing ...
Breaking Biology Technology:Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3
... BMY ) will announce results for the fourth ... During a 10 a.m. (ET) conference call,on Jan. 31, ... from investors and analysts., Investors and the general ... the call at http://www.bms.com/ir or by dialing ...
... Product Progresses in Phase 2 ... ... ), a biotechnology company focused on the development of,compounds for the treatment ... as senior vice president of research,and development. Dr. Taub brings extensive experience ...
... Preparing for the NFL, Combine Use SURGEX(TM) as part of ... ... Clubs(TM), BASKING RIDGE, N.J., Jan. 15 ... MBTG), announced today that SURGEX(TM) is,currently being administered as part of ...
Cached Biology Technology:VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 3VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 4Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 2Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 3Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 4
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Mouse monoclonal antibody to RNase L...
Anti (porcine) Vitronectin...
... Rabbit polyclonal to BMP2 BMP2 ... beta (TGFB) superfamily. Bone morphogenic protein ... candidate gene for the autosomal dominant ... Immunogen: Synthetic peptide: ...
Biology Products: