Navigation Links
Newly found enzymes may play early role in cancer
Date:12/24/2008

SALT LAKE CITYResearchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors.

"We could conceivably reactivate a completely normal gene in a tumor cell a gene that could prevent the growth of a tumor if reactivated," says David Jones, Ph.D., professor of oncological sciences at the University of Utah and senior director of early translational research at the university's Huntsman Cancer Institute (HCI).

"We believe this could be one of the earliest processes to go wrong in cancer," he adds. "By manipulating these enzymes, we could possibly prevent or slow the onset of tumors."

The enzymes appear to control an "onand-off switch" for critical genes that could trigger cancer or numerous other diseases and birth defects. The research is published in the December 26 issue of Cell.

Using zebrafish that share similar genetics to humans, the HCI scientists identified a previously unknown enzyme process that controls the levels of DNA methylation on genes.

"Methylation is a cellular process that is required for healthy cell growth and development, but it can go awry in cancer and diseased cells," says Brad Cairns, Ph.D., HCI investigator and professor of oncological sciences at the University of Utah. "You can think of DNA methylation as an on-and-off switch. Methylation silences or 'shuts off' genes that need to be turned off or are not functioning as they should, whereas the reverse process called demethylation 'turns on' healthy genes and genes needed at critical times in development," he says.

In cancer, this methylation process goes haywire, leading to tumor growth. Genes that should be "turned on" are not and vice versa.

The significance of this research is the discovery of two enzymes involved in DNA demethylatio
'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly identified gene powerful predictor of colon cancer metastasis
2. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
3. Genes newly explained effect on height may change tumor disorder treatment
4. Newly discovered molecular switch helps decide cell type in early embryo development
5. Newly discovered monkey is threatened with extinction
6. Leatherback turtles newly discovered migration route may be roadmap to salvation
7. Newly described dragon protein could be key to bird flu cure
8. Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
9. Newly identified role for power plants in human cells could lead to targeted therapies
10. Newly defined signaling pathway could mean better biofuel sources
11. Newly-identified exercise gene could help with depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... -- The announcement comes as demand for ... (GRM), Ireland,s foremost records management company, ... up an impressive track record of clients within the first ... records management sector in Dubai . As ... and employ a further eight staff members at its Irish ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... in California,s Yolo Bypass provide,an all-you-can-eat bug buffet ... the sea. That,s according to a new report,detailing ... fish,in harvested rice fields earlier this year, resulting ... state,s rivers. The report, provided to the ...
... leading scientists for discussions about the causative agents ... diseases of humans, including malaria, amoebic dysentery, sleeping ... Cell Biology of Eukaryotic Pathogens Symposium takes place ... environment for scientific discussions centered on current research ...
... hear relies on hair cells, sensory receptors that mechanically amplify ... channel. Although the transduction channel was characterized more than 30 ... components. A new study in The Journal of ... identification of this mystery channel. Recent studies have ...
Cached Biology News:For fish and rice to thrive in Yolo Bypass, 'just add water' 2For fish and rice to thrive in Yolo Bypass, 'just add water' 3
(Date:4/24/2015)... April 24, 2015  Pfenex Inc. (NYSE MKT: PFNX) ... biosimilar therapeutics including high value and difficult to manufacture ... offering of 6,000,000 shares of its common stock at ... Of the shares being offered, 2,610,000 are being offered ... offered by existing stockholders. Pfenex will not receive any ...
(Date:4/24/2015)... April 24 , 2015 PAREXEL International ... services provider, today announced that Partnerships in Clinical Trials ... Management, the 2015 Clinical Innovator of the Year.  The ... team for the Company,s Perceptive MyTrials ® Data-Driven ... Thursday night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... Athena San Diego, an organization that ... in San Diego’s technology and life science sectors, will ... at their Gala on April 30, 2015 from 5-9pm ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals ... vision of fostering networking, risk taking and diversity of ...
(Date:4/23/2015)... 2015 BioTE Medical President and Founder ... Live Happier - Avoiding Over-Medication through Natural Hormone Balance" ... Group Conference at JW Marriott / Ritz Carlton Grande ... Healthier Live Happier, is a welcomed response to many ... for a higher quality of life thanks to bio-identical ...
Breaking Biology Technology:Pfenex Inc. Announces Pricing Of Follow-on Offering 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3
... work in MIT Institute Professor Robert Langers prolific lab sounds ... its products are already saving lives around the world in ... growing the vital tissues of the human bodyincluding skin, blood ... and intestinesin a laboratory dish instead of in the body. ...
... the promise of nanotechnology is great, but there are risks ... The new technology, which is making its way into products ... among scientists than the general public, with scientists appearing to ... of risk versus reward both groups seem to agree ...
... EATONTOWN, N.J., Feb. 15 Osteotech, Inc.,(Nasdaq: ... quarter and year,ended December 31, 2007 financial results ... call will be conducted by Sam Owusu-Akyaw,President and ... of,Osteotech management, on Wednesday, February 20, 2008, at ...
Cached Biology Technology:MIT researcher addresses biomedical engineering challenges 2MIT researcher addresses biomedical engineering challenges 3Nanotech's health, environmental impacts worry scientists and the public 2Nanotech's health, environmental impacts worry scientists and the public 3
... Cells and TriEx Insect Cell Medium are ... constructs. This cell/medium combination has been selected ... high protein expression levels observed specifically with ... note that our Ready-Plaque Sf9 Cells and ...
...
...
...
Biology Products: