Navigation Links
Newly found enzymes may play early role in cancer
Date:12/24/2008

SALT LAKE CITYResearchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors.

"We could conceivably reactivate a completely normal gene in a tumor cell a gene that could prevent the growth of a tumor if reactivated," says David Jones, Ph.D., professor of oncological sciences at the University of Utah and senior director of early translational research at the university's Huntsman Cancer Institute (HCI).

"We believe this could be one of the earliest processes to go wrong in cancer," he adds. "By manipulating these enzymes, we could possibly prevent or slow the onset of tumors."

The enzymes appear to control an "onand-off switch" for critical genes that could trigger cancer or numerous other diseases and birth defects. The research is published in the December 26 issue of Cell.

Using zebrafish that share similar genetics to humans, the HCI scientists identified a previously unknown enzyme process that controls the levels of DNA methylation on genes.

"Methylation is a cellular process that is required for healthy cell growth and development, but it can go awry in cancer and diseased cells," says Brad Cairns, Ph.D., HCI investigator and professor of oncological sciences at the University of Utah. "You can think of DNA methylation as an on-and-off switch. Methylation silences or 'shuts off' genes that need to be turned off or are not functioning as they should, whereas the reverse process called demethylation 'turns on' healthy genes and genes needed at critical times in development," he says.

In cancer, this methylation process goes haywire, leading to tumor growth. Genes that should be "turned on" are not and vice versa.

The significance of this research is the discovery of two enzymes involved in DNA demethylatio
'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly identified gene powerful predictor of colon cancer metastasis
2. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
3. Genes newly explained effect on height may change tumor disorder treatment
4. Newly discovered molecular switch helps decide cell type in early embryo development
5. Newly discovered monkey is threatened with extinction
6. Leatherback turtles newly discovered migration route may be roadmap to salvation
7. Newly described dragon protein could be key to bird flu cure
8. Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
9. Newly identified role for power plants in human cells could lead to targeted therapies
10. Newly defined signaling pathway could mean better biofuel sources
11. Newly-identified exercise gene could help with depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ... robust – with the clinical data to back it ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a ... Funding for this $50 million capital project is part ... launched next summer. The medical education ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in ... plans to be ready to welcome medical students in ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... buildings and monuments may be better protected from decay ... Researchers at the University of Edinburgh have devised a ... stone buildings including statues, monuments and other historic ... development allows conservationists to estimate the likely impact of ...
... By creating a unique system of blood vessels that ... implanted device, the longevity and function of these devices ... by researchers in the University of Louisville/ Jewish Hospital,s ... online on August 23, 2010 in the Journal ...
... studies show that treatments targeting specific viral genes protected ... the animals were protected even when therapeutics were administered ... treating accidental infections in laboratory or hospital settings. ... the journal Nature Medicine , was conducted by ...
Cached Biology News:Study offers historic buildings protection from climate change 2New technology may prolong the life of implanted devices, from pacemakers to chemotherapy ports 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 3
(Date:12/22/2014)... -- GenomeDx Biosciences today announced that a new study ... test for prostate cancer, was able to predict rapid ... prostatectomy without adjuvant therapy. Although rapid metastasis in men ... genomics to identify these men who have a highly ... The study has been published online by the ...
(Date:12/22/2014)... The American Journal of Hematology/Oncology, a ... editorials addressing developments and pathways related to oncological ... article exploring the role of follicle-stimulating hormone (FSH) ... prostate cancer. , The article references seminal ... there could be a connection to prostate cancer ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... 28 Clarisonic announced today the expansion of its ... with Look Good…Feel Better ®, ... with breast and other cancers manage their treatment and ... program,s free workshops, volunteer beauty professionals teach patients easy ...
... at the University of New South Wales (UNSW) in Sydney, ... to make a quantum computer using silicon: a "single electron ... Quantum computers promise exponential increases in processing speed over ... orientation, of individual electrons to represent data in their calculations. ...
... day recycle part of their own waste heat, using a ... The material is a semiconductor called gallium manganese arsenide. In ... describe the detection of an effect that converts heat into ... a semiconductor. Once developed, the effect could enable integrated ...
Cached Biology Technology:Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 2Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 3Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 4Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 5Single electron reader opens path for quantum computing 2Semiconductor could turn heat into computing power 2Semiconductor could turn heat into computing power 3
Lysozyme C (W-20)...
... BR4i refrigerated multifunction centrifuges are equally capable of ... low sound level with a large range of ... rotor exchange system without tools ensures that the ... Instant rotor exchange (5 sec.) ...
... (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a chromogenic ... recombinant plasmids. In the ... IPTG, lac + ... whereas recombinant colonies appear ...
... AcTEV Protease is an enhanced form of ... highly site-specific, highly active, and significantly more ... long-term activity. AcTEV Protease specifically recognizes a ... and Gly), making it useful for removing ...
Biology Products: