Navigation Links
Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
Date:2/3/2014

Researchers from Virginia Commonwealth University (VCU) Massey Cancer Center have discovered a new signaling pathway in sterile inflammation that could impact the treatment of diseases such as cancer, multiple sclerosis and rheumatoid arthritis. Their findings offer insight into the role that activation of interferon-regulatory factor 1 (IRF1), a protein that functions as a transcriptional activator of a variety of target genes, plays in the production of chemokines and the recruitment of mononuclear cells to sites of sterile inflammation.

Although it has been shown that interleukin 1 (IL-1) induces the expression of IRF1, the biological importance of this was uncertain. In this study, recently published in the journal Nature Immunology, investigators Tomasz Kordula, Ph.D., and Sarah Spiegel, Ph.D., members of the Cancer Cell Signaling research program at Massey and professors in the Department of Biochemistry and Molecular Biology at the VCU School Medicine, found a new signaling pathway that links IL-1 to IRF1 in sterile inflammation.

IL-1, a key regulator of sterile inflammation, governs immune and inflammatory responses and has an important role in autoinflammatory diseases. IL-1 signaling triggers a process called polyubiquitination. Polyubiquitination is important to a variety of cellular functions. While one form of polyubiquitination has been called the "kiss of death" because it targets proteins for degradation, another form known as K63-linked polyubiquitination is important to cell signaling.

"For the first time, we found that K63-linked polyubiquitination is a mechanism of IRF1 activation," says Kordula. "Once activated, IRF1 induces potent chemokines that recruit immune cells to sites of sterile inflammation and promote healing."

Kordula and Spiegel, Mann T. and Sara D. Lowry Professor of Oncology and co-leader of the Cancer Cell Signaling research program
'/>"/>

Contact: Alaina Schneider
afschneider@vcu.edu
804-628-4578
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly discovered human peptide may become a new treatment for diabetes
2. Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action
3. Newly identified proteins make promising targets for blocking graft-vs.-host disease
4. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
5. Newly discovered ocean plume could be major source of iron
6. Newly discovered switch plays dual role in memory formation
7. Newly discovered bacterial partnership changes ocean chemistry
8. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
9. Newly identified bone marrow stem cells reveal markers for ALS
10. Newly developed medium may be useful for human health, biofuel production, more
11. A newly discovered hormone makes ovaries grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
(Date:10/15/2014)... Rosenstiel Award for Distinguished Work in Biomedical Science by ... of genomic instability and its implications for the immune ... to win the Rosenstiel Award; the first, Rod McKinnon, ... the Charles A. Janeway Professor of Pediatrics and Professor ... at the Howard Hughes Medical Institute at Boston Children,s ...
(Date:10/14/2014)... discriminating thieves, prostate cancer tumors scavenge and hoard copper ... such avarice may be a fatal weakness. , ... kill prostate cancer cells by delivering a trove of ... diseased cells brimming with the mineral, leaving non-cancer cells ... already commercially available for other uses, could soon be ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Prostate cancer's penchant for copper may be a fatal flaw 2
... issues, 100 percent fruit and vegetable juices do help reduce ... conclusion is the result of a European study designed to ... significant role in reducing risk for both cancer and cardiovascular ... are comparable in their ability to reduce risk compared to ...
... created from poultry feathers may add value to ... environmental problem of plastic waste. , According to ... million tons of non-biodegradable plastic waste ends up ... of biological systems engineering at Virginia Tech, is ...
... to process information more chaotically than has long been ... by scientists at the University of Bonn. The passing ... they show, occur exclusively at the synapses, i.e. the ... that the neurons release their chemical messengers along the ...
Cached Biology News:100 percent juices found as beneficial to health as fruits and vegetables 2Researcher examines polymers created with poultry feathers 2Brain works more chaotically than previously thought 2Brain works more chaotically than previously thought 3
(Date:10/19/2014)... 2014 The report "Chocolate, Cocoa Beans, ... Prices, Geography Trend and Forecast (2011 - 2016)," ... geography and studies the major market drivers, restraints, and ... and Asia. , The global chocolate market is expected ... in 2016 at an estimated CAGR of 2.7% from ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and ... analyzes the global market on the basis of ... details such as the key drivers, current trends ... Browse 81 Market Data Tables and 29 Figures ... “1,6-Hexanediol Market by Application and by Geography - ...
(Date:10/18/2014)... 18, 2014 The Asia-Pacific Liquid Crystal ... the concerned market in Asia-Pacific with analysis and forecast ... in 2013, and is expected to reach $380.0 million ... to 2018. , Browse through the TOC of the ... of the in-depth analysis provided. This also provides a ...
Breaking Biology Technology:Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3
... Therapeutics Corporation today,announced that Blake M. Paterson M.D., ... in Bioscience Award from the Greater Baltimore Council.,Dr. ... nominees,submitted by businesses, bioscience advocates, higher education,institutions and ... Dr. Paterson has received this award from the ...
... March 18 Caliper Life,Sciences, Inc. (Nasdaq: ... the,Lehman Brothers Global Healthcare Conference in Miami, will ... EDT. Kevin Hrusovsky, President and CEO of,Caliper, will ... The live,webcast can be accessed at, http://cc.talkpoint.com/LEHM002/031808a_jw/default.asp?entity=Caliper . ...
... Three biotech CEOs and,the president of one ... by the Greater Baltimore Committee as winners of ... the 2008 Greater Baltimore Region Bioscience Awards are:, ... E. Askew, President & CEO, CSA,Medical, Inc. Askew,s ...
Cached Biology Technology:Blake M. Paterson MD, CEO and Co-founder of Alba Therapeutics, Wins Greater Baltimore Committee 2008 Leadership in Bioscience Award 2Three CEOs and University President Named Winners of Greater Baltimore Committee's 2008 Baltimore Region Bioscience Awards 2