Navigation Links
Newly discovered molecule may offer hope for immune disorders and runaway inflammation
Date:3/31/2014

A new research discovery published in the April 2014 issue of the Journal of Leukocyte Biology may open the door to new therapies that help treat immune disorders or curb runaway inflammation. Specifically, scientists have discovered a molecule that can induce cell death (apoptosis) in a key type of immune cell (dendritic cells). With this understanding, it may be possible to develop new therapies that essentially shut down dendritic cell activity, and thereby reducing an immune reaction.

"We hope that our findings provide better understanding of immune regulation, which might give new insights into identifying new targets for immunotherapies,'" said Young Chul Sung, Ph.D., a researcher involved in the work from the Division of Integrative Bioscience and Biotechnology at the Pohang University of Science and Technology in Pohang, Korea.

To make this discovery, scientists used two groups of mice. One group was bred to lack the molecule believed to induce dendritic cell apoptosis and the second were normal (wild-type). Dendritic cells, obtained from the spleens of both groups of mice, were activated in vivo and in vitro, and apoptosis was determined by flow cytometry. Significantly lower apoptosis was found in the mice lacking the molecule necessary to induce apoptosis, when compared to their counterparts

"Dendritic cells are the essential inducers of immune responses and sense the need to activate many other immune cascades, but sometimes these cells get it wrong," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Understanding how one might selectively induce cell death in dendritic cells may reveal novel opportunities to eliminate these key orchestrators of immune responses in pathogenic settings such as autoimmunity or inflammatory diseases."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Newly identified small-RNA pathway defends genome against the enemy within
2. Newly discovered catalyst could lead to the low-cost production of clean methanol
3. Newly discovered marsupial the victim of fatal attraction
4. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
5. Newly discovered human peptide may become a new treatment for diabetes
6. Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action
7. Newly identified proteins make promising targets for blocking graft-vs.-host disease
8. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
9. Newly discovered ocean plume could be major source of iron
10. Newly discovered switch plays dual role in memory formation
11. Newly discovered bacterial partnership changes ocean chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/10/2016)... 10, 2016 --> ... report "Identity and Access Management Market by Component (Provisioning, ... Governance), by Organization Size, by Deployment, by Vertical, and ... MarketsandMarkets, The market is estimated to grow from USD ... 2020, at a Compound Annual Growth Rate (CAGR) of ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... ... , ... Global Stem Cells Group, a leading international biotechnology company, ... Arica and Iquique in northern Chile. The facilities are part of GSCG’s expanding presence ... advanced protocols and techniques in stem cell medicine to patients from around the world. ...
(Date:5/31/2016)... ... ... Adimarket, a subsidiary of Global Stem Cells Group, Inc. is preparing to ... is expected to be available to physicians in July, 2016. The Progenikine kit contains ... in a closed environment. , Adipose derived stem cells (ASCs) are used by physicians ...
(Date:5/31/2016)... , May 31, 2016 Oxitec ... of the ,Friendly Aedes aegypti Project, to cover ... city of Piracicaba, Brazil .  Due to ... this project may also benefit neighbouring areas of the city. ... solution in an area of 5,000 people in the CECAP/ ...
(Date:5/31/2016)... ... May 31, 2016 , ... RURO, Inc., ... 6.2, a minor release with several important advancements to ease data entry, enhance ... several years, Limfinity® has become one of the most sought after options by ...
Breaking Biology Technology: