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Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
Date:10/24/2008

rge domain on the chromosome, says Chandrasekhar Kanduri. The popular belief is that it is only a gene located in the same area as where the long RNA molecule is transcribed from that can be silenced.

This mechanism is important for understanding the genetic disorder Beckwith-Wiedemann Syndrome. In this condition silencing of the chromosome 11 domain does not function properly and both copies of the genes in the domain become inactive, instead of just one. Less protein is produced from the genes, leading to the excess growth characteristics associated with the syndrome: enlargement of organs in the foetus and an increased risk for tumours in the affected organs.


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Contact: Chandrasekhar Kanduri
kanduri.chandrasekhar@genpat.uu.se
46-073-960-0450
Uppsala University
Source:Eurekalert

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