Navigation Links
Newly discovered human peptide may become a new treatment for diabetes
Date:12/2/2013

Bethesda, MDEven if the obesity trend cannot be reversed, here's hope that it's partner in crimediabetesmight be thwarted. New research published in the December 2013 issue of The FASEB Journal shows how a recently discovered human peptide, called humanin, could lead to powerful new treatments for some people living with diabetes. That's because research in mice and rats shows that a humanin analogue (a peptide molecularly similar to humanin) increases insulin secretion leading to an increase in glucose metabolism within beta cells.

"Diabetes is a major disease that is expected to affect more than 500 million people in the next two decades," said Radhika Muzumdar, M.D., study author from the Departments of Pediatrics and Medicine in the Divisions of Endocrinology and Geriatrics at Children's Hospital at Montefiore at the Albert Einstein College of Medicine in Bronx, New York. "Humanin could be a potential weapon in our arsenal in the fight against this global problem."

To make this discovery, Muzumdar and colleagues tested the effects of humanin on insulin secretion in rats and mice; in groups of cells called islets from the pancreas that contain beta cells; and in cultured mouse beta cell lines. In rats, administration of a humanin analog increased insulin levels in the blood in response to high blood glucose levels. The humanin analog increased insulin secretion in islets from both normal mice as well as islets from diabetic mice. In the next step, researchers confirmed that humanin increases insulin secretion in isolated beta cells. The work also demonstrated that this was closely linked to energy production from metabolism of glucose in beta cells. In addition, when the metabolism of glucose in beta cells was blocked, humanin did not increase insulin secretion. Finally, humanin levels naturally decline with age, suggesting that humanin or its analogues may be benefit patients wi
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
2. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
3. Newly discovered foot points to a new kid on the hominin block
4. Newly found protein helps cells build tissues
5. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
6. Key proteins newly discovered form and function may provide novel cancer treatment target
7. Newly discovered breast milk antibodies help neutralize HIV
8. Newly discovered dinosaur implies greater prevalence of feathers
9. U of M researchers: Newly discovered genetic markers could signal colon cancer development
10. ORNLs newly licensed neutron detector will advance human disease research
11. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... Carolina , 5. Februar 2015 /PRNewswire/ ... als spezialisiertes Logistikunternehmen und hat eine neue ... klinische Logistikfirma (Clinical Logistics Organization – CLO) ... neuen Kampagne lautet First , mit ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... 28, 2015 New Market Research ... Segment Forecasts To 2020 has Been Added to GrandViewReseach.com ... is expected to reach USD 5.10 billion by 2020, ... Inc. IR cameras help identify the site of tissue ... witness surging demand in medical imaging applications. They have ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced ... Overview" report to their offering. , ... an individual is who she/he is claiming to be, and ... person,s unique physical characteristics, such as fingerprint, hand or palm ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... fossil fuels, running factories and driving cars, has altered ... growing in the Northeast, according to a new study ... maple is the most economically valuable tree species in ... syrup and tourist-attracting fall colors. , The ...
... rain, the environmental consequence of burning fossil fuels, running ... the number of sugar maple trees growing in the ... University researchers. , The sugar maple is the ... States because of its high-priced lumber, syrup and tourist-attracting ...
... receptors unique to each nerve cell detect the chemical and ... message to understand what we are smelling or tasting. But ... use many different receptors to sense and interpret everything around ... in molecular concentrations as small as 0.1 percent, the equivalent ...
Cached Biology News:Gene therapy prevents the onset of diabetic symptoms in mice 2Gene therapy prevents the onset of diabetic symptoms in mice 3Acid rain causing decline in sugar maples, say researchers 2Acid rain causing decline in sugar maples, say researchers 3Researchers discover how bacteria sense their environments 2
(Date:3/5/2015)... March 5, 2015   HX360 today announced ... the HX360 Innovation Challenge competition. These companies, ... to be chosen as one of four finalists to ... health system executives and venture capitalists during the Innovation ... takes place at the 2015 HIMSS Annual Conference & ...
(Date:3/5/2015)... Bi-Biomics today announced a discovery ... additive. The improvement in histological quality provided the ... in all daughter cells. , After processing with ... analyzed at 1000-1600x using light microscopy. Phylogenetic ... all daughter cells displayed predominant binary features --- ...
(Date:3/5/2015)... , Mar. 05, 2015 Research and Markets ... of the "Mature Biotech Outlook 2015: New Therapy ... their offering. All biotech companies - ... (CELG), in past year, have given a positive return ... companies have been able to select therapy/niche indication where ...
(Date:3/5/2015)... 05, 2015 RMI ... chronic orthopedic conditions such as meniscal tears, ACL ... and joint pain due to degenerative conditions like ... orthopedic surgeries to promote better post-surgical outcomes. , ... nearly pain-free bone marrow harvesting with two complimentary ...
Breaking Biology Technology:HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 4Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 5
... - In the first two years of the Governor's ... young company on the cutting edge of its respective industry. This ... that continues the trend begun by start ups like Mithridion, Inc., ... tied for first in 2004. , ,As is the custom, the ...
... aimed at galvanizing the high-tech industry in Wisconsin ... ,Several emerging technology companies have earned much-needed start-up ... submitting winning business plans to a competition that ... Business Plan Contest, produced by the Wisconsin ...
... Kauten is taking direct aim at three unfavorable metrics, and ... , ,Kauten, CEO of QBI Life Sciences , recently ... Polymeric Micelles, a core product. The screening, which employed UGT1A1, ... is used to determine whether a drug will become active ...
Cached Biology Technology:Business plan finalists offer peek into entrepreneurial future 2Business plan finalists offer peek into entrepreneurial future 3Business plan finalists offer peek into entrepreneurial future 4Winners of past business plan contests secure funding, credibility 2Winners of past business plan contests secure funding, credibility 3Winners of past business plan contests secure funding, credibility 4QBI's PreserveX product passes initial test 2QBI's PreserveX product passes initial test 3
... Spin Kit is an advanced system for isolating DNA ... can be used directly for any downstream application. ... ready to use in 56 minutes Low melting ... TAE and TBE gels No specialised equipment required ...
... The GenElute™ Minus EtBr Spin Columns provide a ... bromide (EtBr)-free DNA (100 bp to 10 kb) ... The DNA band is excised from an agarose ... within the base of the column are a ...
... The Ultra Silica Bead Kit has been designed ... gels and solutions. Features Ultra ... minutes Uniform silica beads are easy to resuspend ... DNA Highly pure DNA (suitable for PCR) ...
... DNA Kit enables efficient extraction of DNA fragments from ... agarose gels. The procedure uses GelMelt solution to dissolve ... to a silica membrane in a spin column format. ... in low-salt buffer. Each spin column can bind up ...
Biology Products: