Navigation Links
Newly discovered gut virus lives in half the world's population
Date:7/24/2014

Odds are, theres a virus living inside your gut that has gone undetected by scientists for decades. A new study led by researchers at San Diego State University has found that more than half the worlds population is host to a newly described virus, named crAssphage, which infects one of the most common types of gut bacteria, Bacteroidetes. This phylum of bacteria is thought to be connected with obesity, diabetes and other gut-related diseases. The research appears today in Nature Communications.

Robert A. Edwards, a bioinformatics professor at SDSU, and his colleagues stumbled upon the discovery quite by accident. Working with visiting researcher and corresponding author on the study Bas E. Dutilh, now at Radboud University Medical Center in The Netherlands, the researchers were using results from previous studies on gut-inhabiting viruses to screen for new viruses.

In the DNA fecal samples from 12 different individuals, they noticed a particular cluster of viral DNA, about 97,000 base pairs long, that the samples all had in common. When Edwards and his colleagues checked this discovery against a comprehensive listing of known viruses, they came up empty.

The researchers then screened for the virus across the database of the National Institute of Healths Human Microbiome Project (HMP), and Argonne National Laboratory's MG-RAST database, and again found it in abundance in samples derived from human feces.

To prove that the viral DNA they discovered in their computer data actually exists in nature, fellow SDSU virologist John Mokili used a technique known as DNA amplification to locate the virus in the original samples used to build NIHs database.

So we have a biological proof that the virus they found with the computer actually exists in the samples, Mokili said.

This was a new virus that about half the sampled people had in their bodies that nobody knew about.

Its not unusual to go looking for a novel virus and find one, Edwards said. But its very unusual to find one that so many people have in common. The fact that its flown under the radar for so long is very strange.

An ancient virus

The fact that its so widespread indicates that it probably isnt a particularly young virus, either.

Weve basically found it in every population weve looked at, Edwards said. As far as we can tell, its as old as humans are.

He and his team named the virus crAssphage, after the cross-assembly software program used to discover it.

Some of the proteins in crAssphages DNA are similar to those found in other well-described viruses. That allowed Edwards team to determine that their novel virus is one known as a bacteriophage, which infects and replicates inside bacteriaand using innovative bioinformatic techniques, they predicted that this particular bacteriophage proliferates by infecting a common phylum of gut bacteria known as Bacteriodetes.

Gut punch

Bacteriodetes bacteria live toward the end of the intestinal tract, and they are suspected to play a major role in the link between gut bacteria and obesity. What role crAssphage plays in this process will be a target of future research.

Further details about crAssphage have been difficult to come by. Its unknown how the virus is transmitted, but the fact that it was not found in very young infants fecal samples suggests that it is not passed along maternally, but acquired during childhood. The makeup of the viral DNA suggests that its circular in structure. Further laboratory work has confirmed that the viral DNA is a singular entity, but its proven difficult to isolate.

We know its there, but we cant capture it quite yet, Edwards said.

Once the virus is isolated, he hopes to delve into its role in obesity. Its possible the virus in some way mediates the activity of Bacteriodetes colonies, but whether crAssphage promotes or suppresses obesity-related processes in the gut remains to be seen.

The virus might also be used to prevent or mitigate other diseases affected by the gut such as diabetes and gastroenterological maladies.

Once these processes are better understood, Edwards envisions one day the possibility of personalized medicine based on this virus.

This could be a key to personalized phage medicine, he said. In individuals, we could isolate your particular strain of the virus, manipulate it to target harmful bacteria, then give it back to you.


'/>"/>

Contact: Natalia Elko
natalia.elko@mail.sdsu.edu
619-594-2585
San Diego State University
Source:Eurekalert

Related biology news :

1. When temperatures get cold, newly-discovered process helps fruit flies cope
2. Die-offs of band-tailed pigeons connected to newly discovered parasite
3. Newly identified gene provides reliable visual cue for oil palm fruit ripeness
4. Newly discovered paddle prints show how ancient sea reptiles swam
5. Newly identified B-cell selection process adds to understanding of antibody diversity
6. Newly identified brain cancer mutation will aid drug development
7. Newly found dinosaur is long-nosed cousin of Tyrannosaurus rex
8. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
9. Newly identified small-RNA pathway defends genome against the enemy within
10. Newly discovered catalyst could lead to the low-cost production of clean methanol
11. Newly discovered marsupial the victim of fatal attraction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2016)... 2016 Securus Technologies, a leading provider of ... investigation, corrections and monitoring, announced today that it has ... have an independent technology judge determine who has the ... tech/sophisticated telephone calling platform, and the best customer service. ... most of what we do – which clearly is ...
(Date:11/15/2016)... 15, 2016  Synthetic Biologics, Inc. (NYSE MKT: ... on the gut microbiome, today announced the pricing ... of its common stock and warrants to purchase ... price to the public of $1.00 per share ... from the offering, excluding the proceeds, if any ...
(Date:6/27/2016)... Research and Markets has announced the addition ... to their offering. The report ... to grow at a CAGR of 12.28% during the period 2016-2020. ... in-depth market analysis with inputs from industry experts. The report covers ... The report also includes a discussion of the key vendors operating ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... Eurofins announces the appointment of Sean Murray , ... Inc. (ESI). Mr. Murray will bring valuable expertise ... experience in leading international business teams. As the National Division Leader, ... uphold Eurofins, status as the global leader in bio-analytical testing services. ... , , ...
(Date:12/8/2016)...  Anaconda BioMed S.L., a pre-clinical stage medical device ... neuro-thrombectomy system for the treatment of Acute Ischemic Stroke ... to join its Scientific Advisory Board (SAB). The SAB ... scientific and clinical experts to Anaconda BioMed S.L., as ... ® to its clinical phase. The SAB is ...
(Date:12/8/2016)... 8, 2016  Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... on developing and commercializing products to treat rare ... announced today the long-term follow-up data from its ... first-in-class Innate Defense Regulator (IDR), in the treatment ... cancer patients undergoing chemoradiation therapy (CRT).  The additional ...
(Date:12/8/2016)... , Dec. 8, 2016  Partnering to fuel ... Ben Franklin Technology Partners of Southeastern Pennsylvania ... ("IHG"), the parent company of Independence Blue Cross; and ... announced their intentions for a $6 million funding initiative ... healthcare startups. Responding to a burgeoning economic ...
Breaking Biology Technology: