Navigation Links
Newly discovered gene fusion may lead to improved prostate cancer diagnosis
Date:7/23/2009

Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers. The results may lead to more accurate prostate cancer testing and new targets for potential treatments. Experts believe that gene fusions -- a hybrid gene formed from two previously separated genes -- may be at the root of what causes cancer cells to grow more quickly than normal cells.

The new findings, published in the August issue of the journal Neoplasia, are exciting, because unlike two previous fusions co-discovered by the same Weill Cornell Medical College laboratory group, this fusion, called NDRG1-ERG, produces a protein that may be a potential target for drug therapies.

"The prostate cancer gene fusions, and proteins they produce, are important because they serve as a cancer-specific marker," says Dr. Mark A. Rubin, the Homer T. Hirst Professor of Oncology in Pathology, professor of pathology and laboratory medicine, and vice chair for experimental pathology at Weill Cornell Medical College. "Currently, PSA testing is the standard of care, yet it is not accurate enough to predict prostate cancer, because many men may have an elevated PSA level, but have benign conditions such as inflammation of the prostate."

It is important to distinguish harmful cancer from non-lethal diseases, such as benign prostatic hyperplasia, or enlarged prostate disease that exhibits similar symptoms to prostate cancer, in order to provide effective care, explains Dr. Rubin. Gen-Probe, a biotechnology diagnostics company, has licensed this technology and is currently working with Dr. Rubin, and his collaborator Dr. Arul Chinnaiyan at the University of Michigan, to develop urine tests to screen for gene fusions as a means of improving upon the current standard PSA test.

Dr. Rubin, working in collaboration with Dr. Chinnaiyan's group at the University of Michigan, prev
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly discovered snow roots are evolutionary phenomenon
2. Newly discovered reactions from an old drug may lead to new antibiotics
3. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
4. Newly discovered gene plays vital role in cancer
5. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
6. Newly described contaminant sources in Katrina-flooded homes pose health risks
7. UC Davis research shows that newly discovered drug reduces heart enlargement
8. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
9. Newly found enzymes may play early role in cancer
10. Newly identified gene powerful predictor of colon cancer metastasis
11. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
(Date:3/20/2015)... 2015 Research and Markets ( ... "India Sensors Market Forecast and Opportunities 2020" ... sensor market is projected to grow at a ... electronics, automotive, industrial and healthcare sectors are the ... In addition, adoption of MEMS technology in sensors ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... 22, 2014) Columbia University Medical Center (CUMC) researchers ... appears to play a major role in motor neuron ... Lou Gehrig,s disease. The findings, made in mice, explain ... by the disease and identify a potential therapeutic target ...
... Eurofins MWG Operon, a leader in next generation ... with the Ion Proton Next Generation Sequencer. ... also awarded after joining Life Technologies Corporation,s Ion ... in Life Technologies, CSP program is exclusive and ...
... Research Conference focuses on recent advances in our ... and lipid targets that are known to play ... human cancers. This FASEB Conference ... industry for presentations, discussion, and collaboration to broaden ...
Cached Biology News:Study identifies gene tied to motor neuron loss in ALS 2Study identifies gene tied to motor neuron loss in ALS 3
(Date:3/27/2015)... YORK , March 27, 2015  Peter Walter ... Biomedical Science for his pioneering work on how proteins ... components of a regulatory mechanism that cells use to ... Dr. Walter is a professor of biochemistry at the ... groundwork for treating a range of human diseases related ...
(Date:3/27/2015)... ROCKVILLE, Md. , March 27, 2015  CASI ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a commercial focus on ... the three and 12 months ended December 31, 2014.  ... of ($1.6 million), or ($0.05) per share, for the ...
(Date:3/26/2015)... San Bruno, CA (PRWEB) March 26, 2015 ... organization (CRO), announced today several management and executive ... role of Chief Financial Officer (CFO) and member of ... Vice President of Business Operations, and Sue Dowden will ... Tony Taricco, co-founder and current Chief Operations Officer (COO), ...
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
Breaking Biology Technology:German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3
... cheap, sustainable solar energy by imitating nature. Nanotechnology researchers ... exploring nanoscale materials that mimic the architecture of grass ... , A new podcast looks at how Dr. ... imbed tiny nanoparticles into simple, inexpensive everyday products like ...
... -- (Sept. 18, 2007) -- Biomedical engineers at The ... Houston have announced pre-clinical test results in the September ... feasibility of a smart particle insulin release system that ... releases insulin to counteract them. , Designed to mimic ...
... Inc.,(Nasdaq: OSTE ), a global leader in ... announced today that Sam Owusu-Akyaw,Osteotech,s President and Chief ... Annual West Coast Emerging Growth Institutional Investor,Forum at ... is,scheduled to present at 8:30 a.m. Pacific Time ...
Cached Biology Technology:Smart insulin nanostructures pass feasibility test, UT study reports 2
... System brings together two mature, well-understood ... capture surfaces. This combination produces a ... the detection of molecular binding events ... , Protein-specific capture molecules are immobilized ...
... polymers) are prepared by ... the enzyme, polynucleotide phosphorylase, ... the appropriate, ribonucleoside diphosphate ... exception of catalog number ...
... comprehensive experiment based analysis package designed with ... sophisticated and powerful functionality., Image acquisition interface ... for easy image capture. Sequential and ... Playback Saturation Warning ...
...
Biology Products: