Navigation Links
Newly discovered epidermal growth factor receptor active in human pancreatic cancers
Date:4/18/2009

Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied.

In a presentation April 18, at Experimental Biology 2009 in New Orleans, Dr. Pandey explained why this finding and related work in his Hopkins laboratory is promising in terms of both a new treatment for a large subset of pancreatic cancers and a potential blood or urine screening tool that might eventually do for pancreatic cancer detection what biomarkers like prostate-specific antigen levels have done for prostate cancer. His presentation was part of the scientific program of the American Society for Investigative Pathology.

Personalized treatment. Phosophorylated epidermal growth factor receptor (pEGFR), the receptor identified by Dr. Pandey, is closely related to HER-2, a growth factor receptor found and used as a drug target in a subset of breast cancers. After he found and profiled the pEGFR activated in the pancreatic cancers, Dr. Pandey realized the same receptor had been found by other researchers to be activated in a subset of lung cancers. And, most promising, an EGFR inhibitor named erlotinib already has been through the long and complex Food and Drug Administration approval process and is in use for treatment of these specific lung cancers.

But would the drug work in pancreatic cancers? Dr. Pandey's group moved from studies of human cell lines to studies in mice in which human pancreatic tumor cells with activated EGFT had been placed. The tumors began growing. But when treated with erlotinib, they began to shrink. Other tumors without activated pECFR showed no response.

The promise and the challenge of using pEGFR is that of personalized medicine, says Dr.
'/>"/>

Contact: Sylvia Wrobel
ebpress@gmail.com
770-722-0155
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly discovered gene plays vital role in cancer
2. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
3. Newly described contaminant sources in Katrina-flooded homes pose health risks
4. UC Davis research shows that newly discovered drug reduces heart enlargement
5. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
6. Newly found enzymes may play early role in cancer
7. Newly identified gene powerful predictor of colon cancer metastasis
8. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
9. Genes newly explained effect on height may change tumor disorder treatment
10. Newly discovered molecular switch helps decide cell type in early embryo development
11. Newly discovered monkey is threatened with extinction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... – Bacteria in the gastrointestinal tract fulfill many ... these same bacteria can induce strong inflammatory responses ... gut and enter the bloodstream. , Although acute ... body, chronic or systemic inflammation is linked to ... the involvement of inflammatory processes in the development ...
(Date:10/30/2014)... 2014  Securus Technologies, a leading provider ... for public safety, investigation, corrections and monitoring, ... enhancements to its THREADS™ product, which utilizes ... intelligence and focused leads for investigators. ... innovation through identifying and delivering solutions serving ...
(Date:10/29/2014)... its kind to date, researchers have used DNA sequencing ... for autism. Joseph Buxbaum, Ph.D., Icahn School of Medicine ... Broad Institute of Harvard and MIT, and their colleagues ... parents and unrelated people. They identified changes in 107 ... for autism spectrum disorder (ASD) – a jump from ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2
... Institute for Research in Immunology and Cancer (IRIC) at ... quantity of laboratory stem cells from a small number ... multidisciplinary team, directed by Dr. Guy Sauvageau, thus took ... treatment based on these stem cells. This worldwide first ...
... kind study examining the effects of methamphetamine use during pregnancy ... in children. The research is published in the April 15, ... of the American Academy of Neurology. "Methamphetamine ... leading to an increasing number of children with prenatal meth ...
... In acute ischemic stroke, the blood supply to the ... of oxygen. In addition, ischemia activates harmful inflammatory processes ... first time, scientists at the Neurology Clinic at Heidelberg ... the blood inhibit inflammation after a stroke. These cells ...
Cached Biology News:World premiere in stem cell research in Montreal 2Prenatal meth exposure linked to abnormal brain development 2'First aid' for brain cells comes from blood 2
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... The report "Data Center Networking ... Equipment, WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts ... center networking market into various segments with an ... also identifies the factors driving this market, various ... with the future roadmaps. , Browse 106 market ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4
... Wis. - Building efficiency and power solutions giant ... of its executive positions reflecting the creation an Executive ... president, was named chairman of the EOC, a committee ... since 1982, Roell served as vice president and chief ...
... at a Pennsylvania teaching and research hospital are integrating ... to distribute information about diabetes, cancer, heart disease, and ... S. Hershey Medical Center recently purchased the Web-based ... forums, and internal staff meetings to medical students and ...
... is a concept that appears a long way from ... genetic-based medicine is closer than we think. , ,In ... identify the patient's predisposition to various diseases, and to ... environmental characteristics. , , Stephens Cracking ...
Cached Biology Technology:Medical College researcher working to make genetic-based medicine a reality 2Medical College researcher working to make genetic-based medicine a reality 3
... has a long and outstanding history ... Several years ago we became aware ... was being modified to inject Xenopus ... redesigning the microdispenser to eliminate any ...
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
Rabbit polyclonal to Synapsin II ( Abpromise for all tested applications). entrezGeneID: 6854 SwissProtID: Q92777...
... primers are designed for sequencing inserts cloned ... T7, or T3 RNA polymerase promoters, or ... supplied at a concentration of 0.1 µg/µl ... in DNA sequencing reactions using SequiTherm™ EXCEL™ ...
Biology Products: