Navigation Links
Newly discovered cell mechanism uses amplified nitric oxide to fight C. diff
Date:8/21/2011

rsal function in protecting cells against microbial proteins, many of which have a design that is conducive to being s-nitrosylated by GSNO," Dr. Stamler says. "In this regard, GSNO-like molecules may represent a new class of antibiotics that can be developed, exploiting the shape changes in numerous bacterial proteins."

In their work, researchers also noted that increased levels of GSNO in the gut of C. diff-infected animals and increased levels of SNO-toxin in stools of patients, directly correlated with deactivation of the toxin, further confirming that the natural mechanism works to reduce disease activity in people. This provides a basis for measuring how much nitric oxide, a key molecule in cell immune activity, has bound to toxins to make SNO and limit the spread of bacteria.

The current treatment of C. diff is difficult and the infection often recurs. Resistance to antibiotics is also a serious worry. The researchers are currently developing a new class of anti-toxin treatment based on these findings. One advantage of such antitoxins, says Dr. Stamler, is that resistance won't occur. The researchers hope that the new treatment can enter clinical trials very rapidly.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Are cancers newly evolved species?
2. Newly discovered molecule essential to resetting body clocks
3. Newly discovered plant fossil reveals more than age
4. Newly discovered natural arch in Afghanistan one of worlds largest
5. Newly discovered dinosaur likely father of Triceratops
6. Newly discovered group of algae live in both fresh water and ocean
7. Georgia Tech team helps decode newly sequenced strawberry genome
8. WHO Fracture Risk Assessment Tool (FRAX) newly released for Singapore
9. Remarkable biological complexity of bacterial cells is focus of newly released book
10. Newly discovered gene enables fish to disappear
11. Chocolate farmers could benefit from newly sequenced cacao genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has ... - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally different ... the first time a fingerprint sensor in its product. ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Sensor Market 2015-2019" report to their offering. ... major trend upcoming in this market is the increasing ... help in recording of patient data for quick and ...
(Date:12/11/2014)... and Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... the addition of the "Biometrics Market in India ... One major trend emerging in this market is the ... more than one characteristic of an individual for verification ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... issue of the prestigious journal Nature Chemical ... Emile Van Schaftingen (Louvain University), and Andrew D. ... but so far neglected, part of metabolism, namely ... its repair or pre-emption, the authors present a ...
... , Jan. 30, 2013 /PRNewswire-iReach/ -- BlueMetal Architects, a leading ... appointed former Microsoft Health Solutions Group Director and Health IT ... Vice President of Health & Life Sciences.  Mr. Le ... Boston office and will be responsible for leading ...
... noninvasive, and low-cost method for the early detection and monitoring ... on its way, thanks to research by UC Santa Barbara ... of Materials. By studying patterns of friction between cartilage ... is more likely to cause wear and damage. Their work ...
Cached Biology News:How our cells cope with toxic small molecules 2Bluemetal Architects appoints David Le Penske as Vice President of Health & Life Sciences 2Bluemetal Architects appoints David Le Penske as Vice President of Health & Life Sciences 3UCSB research provides insight into mechanics of arthritis 2UCSB research provides insight into mechanics of arthritis 3
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... Selexis SA, a serial innovation company with proven ... for drug discovery to commercial manufacturing, announced today all ... Sequencing (NGS) data packages. The NGS analysis of ... the integrity of the gene, validation of the left ...
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a pre-market ... (FDA) for the use of Medtronic,s SynchroMed ® ... catheter) for use with United Therapeutics, Remodulin ® ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... DALLAS, Sept. 18 More than 60 physicians credentialed,to ... Hospital of,Dallas were honored by D Magazine at its ... is one of the premier specialty surgical,hospitals in the ... so many of,our physicians again included in this prestigious ...
... Bioreactor (S.U.B.) To Its Portfolio Of Assets ... ... Laureate Pharma, Inc., a,full-service biopharmaceutical development and protein production company,today announced that ... Acquisition of a 250L and a,1000L S.U.B. will give Laureate greater flexibility ...
... will use their extensive field sales expertise and established relationships ... engineered ceramic manufacturing design, development and testing expertise. , ... ... -- JD Technologies, LLC, an effective field sales company and ...
Cached Biology Technology:Annual List of 'Best Doctors in Dallas' Showcases Texas Institute for Surgery Physicians 2Laureate Pharma to Add More Manufacturing Capacity 2JD Technologies, LLC Selected by FCT Ingenieurkeramik GmbH to Represent Their High Performance Ceramic Expertise In the United States 2JD Technologies, LLC Selected by FCT Ingenieurkeramik GmbH to Represent Their High Performance Ceramic Expertise In the United States 3
... Complete Solution Polymorphic DNA ... We provide a complete solution for SNP ... assay design, oligonucleotide primers, PCR amplification, DNA ... For SNP discovery, Polymorphic uses ...
... top-of-the-line PowerPac 3000 power supply is ... ideal for isoelectric focusing, DNA sequencing, ... electrophoresis, western blotting, and submerged gel ... of powre, the PowerPac 3000 power ...
... and PowerPac basic power supply are used for ... agarose gels. This Model 192 cell includes a ... gel tray with fluorescent ruler, and a gel ... 220-240 V, provides output of 10-300 V, 4-400 ...
... clear advantages over traditional electrophoresis for ... mutation analysis, and size polymorphisms analysis. ... connectivity is ideal for basic research, ... The P/ACE Series automated capillary electrophoresis ...
Biology Products: