Navigation Links
Newly described type of immune cell and T cells share similar path to maturity
Date:5/14/2013

PHILADELPHIA Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells (ILCs). Some researchers liken them to foot soldiers that protect boundary tissues such as the skin, the lining of the lung, and the lining of the gut from microbial onslaught. They also have shown they play a role in inflammatory disease, when the body's immune system is too active.

In animal studies, group-2 innate lymphoid cells (ILC2s) confer immunity during a parasitic infection in mice and are also involved in allergic airway inflammation. A team of Perelman School of Medicine, researchers from the Departments of Medicine, Microbiology, Pathology and Laboratory Medicine, and Cancer Biology, found that maturation of ILC2s requires T-cell factor 1 (TCF-1, the product of the Tcf7 gene) to move forward. TCF-1 is protein that binds to specific parts of DNA to control transcription of genetic information from DNA to messenger RNA.

Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, and Qi Yang, PhD, a postdoc in the Bhandoola lab, describe in Immunity that one mechanism used to build ILCs is the same as that in T cells. Both cell types use a protein pathway centered on Notch that the lab of coauthor Warren Pear, MD, PhD, also in the Pathology and Laboratory Medicine, has studied for the last two decades. Other contributing authors are from the laboratory of David Artis, PhD in Microbiology, that are experts in ILC function, and Angela Haczku, MD, PhD, in the Department of Medicine, who focuses on asthma.

But what makes ILCs and T cells different in their final development? T cells are made in the thymus. ILCs don't need the thymus, but researchers don't know exactly where they are produced, just that the thymus isn't essential for their normal development, unlike T cells.

In the Immunity study, mice without the Tcf7 gene also lack IL
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. FRAX newly released as version 3.8 -- Over 5 million online calculations since June 2011
2. Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight
3. Soils in newly forested areas store substantial carbon that could help offset climate change
4. Logging debris gives newly planted Douglas-fir forests a leg-up
5. Newly identified natural protein blocks HIV, other deadly viruses
6. Newly discovered plant structure may lead to improved biofuel processing
7. Newly discovered scarecrow gene might trigger big boost in food production
8. Newly discovered effects of vitamin D on cancer
9. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
10. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
11. ORNLs newly licensed neutron detector will advance human disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... data from over 18,000 patients, scientists have identified ... in Parkinson,s disease, including six that had not ... Nature Genetics , was partially funded by the ... scientists working in NIH laboratories. , "Unraveling the ... the multiple mechanisms involved in this complex disease, ...
(Date:7/25/2014)... colonial era, 100,000s of people lived on the land ... fire to control the availability of plants they used ... to use fire to maintain desired habitat and natural ... Forest Service,s Pacific Southwest Station, will lead a ... Refuge during the Ecological Society of America,s 99th Annual ...
(Date:7/25/2014)... raging this summer and some of the smoke from those ... image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... smoke has descended over the Great Lakes region of the ... image from July 23, 2014 (first image feature highlighted below) ... off southeastward. In the image, it is over Manitoba ...
Breaking Biology News(10 mins):NIH scientists find 6 new genetic risk factors for Parkinson's 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... A spoonful of medicine goes down a lot easier if ... helpful for women living with HIV/AIDS and managing their chronic ... Bolton School of Nursing at Case Western Reserve University. ... managing other chronic illnesses," said Allison R. Webel, instructor of ...
... Ill. Land and marine iguanas and giant tortoises ... the Galpagos islands are more likely to harbor antibiotic-resistant ... sites on the islands, researchers report in a ... sites from free-living reptiles harbored Escherichia coli ...
... release is available in Spanish . ... because of their characteristics, produce a certain amount of social ... fact that they are subjected to moral conflicts and ethical ... very necessary from a social perspective, as in the case ...
Cached Biology News:CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS 2Patterns of antibiotic-resistant bacteria found in Galapagos reptiles 2Moral imagination as a key to overcoming work-related stigmas 2
(Date:7/28/2014)... (PRWEB) July 28, 2014 The National ... in Muncie IN, is pleased to announce that it ... National Museum of the United States Air Force. , ... year-long process that concluded this spring with an on-site ... Dayton, OH museum. , The National Museum of ...
(Date:7/25/2014)... July 26, 2014 "Ischemic Stroke ... 2014" provides data on the Ischemic Stroke and ... elemental information and data relating to the clinical ... View full global Ischemic Stroke Research Report 2014 ... overview of the trial numbers and their recruitment ...
(Date:7/25/2014)... live in each person,s digestive tract. Scientists believe that ... off harmful infections, but their role in human health ... on the role of these bacteria, a team of ... tracked fluctuations in the bacterial populations of two research ... the July 25 issue of the journal Genome ...
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Supports Program to Recognize Exemplary Work, BRIDGEWATER, ... of oncology nurses, Ortho Biotech Products, L. P.,today ... Healer,Award for Oncology Nursing, which honors one of ... their unwavering,dedication, compassion and helpfulness. Last year, more ...
... Exclusive Rights to Oncology Biomarkers, FREMONT, ... VRML ), a high-value molecular diagnostics company, ... with Johns Hopkins University,on the development of ... disease,detection, classification and monitoring of prevalent cancers, ...
... Pharmaceuticals,Inc. (NYSE: BRL ) today announced that its ... Merck & Co., Inc.,s Fosamax(R),(Alendronate Sodium) Tablets, 70 mg ... Administration (FDA)., The FDA approved the Company,s application ... associated with the,earliest to expire of the patents listed ...
Cached Biology Technology:Call for Entries - 2008 CURE Extraordinary Healer Award for Oncology Nursing 2Vermillion and Johns Hopkins Sign Collaborative Research and License Agreements to Develop Molecular Diagnostic Tests 2Barr Launches Generic Fosamax(R) Tablets, 70 mg 2Barr Launches Generic Fosamax(R) Tablets, 70 mg 3Barr Launches Generic Fosamax(R) Tablets, 70 mg 4
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
fli-1...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: