Navigation Links
Newly created cancer stem cells could aid breast cancer research
Date:8/13/2007

ls with high tumor-making and metastatic potential while the standard culture medium favors cells with low tumor-making potential. Although the two types are only slightly different, the cells behave completely differently after acquiring the same mutations.

Ince confirmed this behavioral difference by taking a single human breast tissue sample, splitting it in two and growing the cells in the two culture mediums, which select for different cells. Next, he transformed the two populations with the same tumor-initiating genes, injected them in mice and watched the result. The cells that were grown in the new culture medium were 10,000 times more potent as tumor initiators and were the only ones able to metastasize. Thus genes that were previously thought to only initiate tumors initiated metastasis, which is the main cause of cancer mortality in the clinic.

Tan has demonstrated that a critical determinant of eventual metastasis is the identity of the normal cell type that preexists in the breast and becomes the object of mutation and selection, Weinberg says.


'/>"/>

Contact: Alyssa Kneller
kneller@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. U of M researcher examines newly emerging deadly disease
4. Newly Discovered Compound Blocks Known Cancer-Causing Protein
5. Newly discovered pathway might help in design of cancer drugs
6. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
7. Newly discovered protein an important tool for sleeping sickness research
8. Enzymes newly discovered role may make it target for arthritis treatment
9. Newly discovered genetic disease sheds light on bodys water balance
10. Newly recognized gene mutation may reduce seeds, resurrect plants
11. Drug discovery team to explore newly discovered deep-sea reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... Utah , March 10, 2015   Tute ... interpretation, has been selected by next-generation sequencing company ... of whole exome and targeted gene panel interpretation. ... provider, has adopted the most current technologies to support ... genetic research. The company offers two types of exome ...
(Date:3/4/2015)... 04, 2015 Research and Markets ... the "Global Biometrics Market Forecast and Opportunities, ... The market for biometric authentication systems is projected ... till 2020 The driving forces for ... needs, government projects and constant development in technology. ...
(Date:3/2/2015)... , March 2, 2015  Businesses have a ... protection company Tharon Rankins Enterprises has announced the ... an ultra-safe way for businesses to protect their ... transactions. Beconux is a biometric ... Enterprises. Functioning similarly to an ATM machine, the ...
Breaking Biology News(10 mins):PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 2PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 3Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3Personal Data Protection Company Launches New Product 2
... Putnam Valley, NY. (Dec. 18, 2013) ... therapy for acute liver failure, either for liver ... However, maintaining the viability and functional aspects of ... freezing (cryopreservation). In an effort to improve both ...
... Institute of Science and Technology (UNIST) announced a method ... which led to the fabrication of a graphene-based field ... opportunities for practical use in electronic devices. ... research team led by Prof. Jong-Beom Baek have discovered ...
... Cell biologists at the Ruhr-Universitt Bochum (RUB) have launched ... enzyme Parkin in promoting neuronal survival. The team of ... Physiological Chemistry, Department of Molecular Cell Biology, is looking ... Michael J. Fox Foundation finances this research project with ...
Cached Biology News:Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation 2UNIST research team opens graphene band-gap 2
(Date:3/26/2015)... Ale Gicqueau, Founder and President of ... Affairs at Align Technology, on “ Conducting Postmarket Registries ... 2015 Global Conference and Exhibition on April 25th through ... During the poster presentation, Ale Gicqueau and Victor Chen ... Postmarket Registry, the requirements and resources to conduct the ...
(Date:3/25/2015)... , March 25, 2015 Optimal Research, ... Vaccine Industry Excellence (ViE) Award "Best Clinical Site or ... year that Optimal has been selected as a nominee ... Congress, receiving a "Highly Recommended" distinction in 2014. The ... of the efforts, accomplishments, and positive contributions of companies ...
(Date:3/25/2015)... Mass. and REYKJAVIK, Iceland , ... capabilities for using the genome to create better medicine, today ... the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around the most ... a team of deCODE scientists led by Kari Stefansson ...
(Date:3/25/2015)... 2015 Researchers at Ancon Medical ... that will enable broader and less invasive screening ... a simple breath screen. The Minnesota-based medical device ... and Drug Administration (FDA) approval process and is ... Nanoparticle Biomarker Tagging device. , Ancon Medicals nanoparticle ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 3
... the cleanest, greenest and far and away most abundant ... woefully under-utilized. High costs have been a major deterrant ... - densely packed nanoscale arrays of optically active semiconductors ... of relatively cheap and scalable solar cells, but have ...
... 17, 2010 Nanotrope, Inc. announced today that it ... ground-breaking diagnostic test for influenza and other viral infections. ... an artificial "cell" engineered with specific membrane compositions and ... mimic as it would a normal host cell.  Once ...
... American Heart Association Late Breaker Session ... ... lpUnit=,PRN,; --> ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
Cached Biology Technology:A new twist for nanopillar light collectors 2A new twist for nanopillar light collectors 3Nanotrope, Inc. Receives Patent on New Diagnostic Test for Influenza and Other Viral Infections 2Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 2Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 3Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 4Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 5Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 6Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 7Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 8Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 9Resverlogix Presents ASSERT Human Clinical Trial Data at the American Heart Association Late Breaker Session 10
Experion Pro260 chips are the microfluidic chips used to perform protein analysis with the Experion automated electrophoresis system. Each chip has the capacity to run 10 protein samples. Supplied as...
... reagents and supplies, for 10 chips, ... to perform protein analysis with 10 ... system. Supplied are 3 x 520 ... stain, 60 microliters Pro260 ladder (10-260 ...
... LabChip 3000 drug discovery system miniaturizes, ... assays. Using LabChip technology, the ... a serial, continuous flow fashion. LabChip ... of results exceeds what is achievable ...
... fast and reliable automation for today's ... development laboratories. Staccato Mini-Workstations offer the ... basic liquid handling and material management ... either Caliper's time proven CLARA™ assay ...
Biology Products: