Navigation Links
Newly created cancer stem cells could aid breast cancer research
Date:8/13/2007

ocedure.

The engineered cells proved to be extremely powerful. When Ince injected more than 100,000 of them into a mouse with a compromised immune system, it quickly developed massive, deadly tumors. In initial experiments, a few tissue slices revealed a primary tumor structure that resembled that of cancer patients with metastases.

That prompted Ince to wonder whether the cancer cells he created would metastasize if the mouse lived longer. He repeated the experiment in other mice, reducing the number of cells in the injection to as few as 100 in hopes of slowing tumor growth. The cancer cells continued to seed tumors and those tumors metastasized. In sharp contrast, scientists must inject about 1 million cells to get a tumor when working with the cancer cell lines routinely used in the laboratory.

In the process of making a model that reflects a tumor type common in patients, I created tumor-initiating cells, Ince explains. That was a complete surprise.

This work could provide a boon to researchers who study these elusive cancer stem cells by offering a bountiful source of them, maintains Weinberg. Labs can easily grow the newly created cells for use in experiments.

The study, which appears in Cancer Cell on August 13, also offers clues about the trajectory of cancer cells. A normal cell is thought to evolve progressively toward a malignant state through a series of genetic mutations. The early alterations confer uncontrolled growth, while later alterations enable the cell to migrate and invade other tissues. Over the past decades, considerable effort has gone into discovering these tumor-initiating and metastasis-initiating genetic alterations.

The new study suggests, however, that some normal cells are more prone to become tumor-initiating cells and have a higher metastatic potential when they become cancer cells than other normal cells. The culture medium Ince created favors the growth of the human breast cel
'/>"/>

Contact: Alyssa Kneller
kneller@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. U of M researcher examines newly emerging deadly disease
4. Newly Discovered Compound Blocks Known Cancer-Causing Protein
5. Newly discovered pathway might help in design of cancer drugs
6. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
7. Newly discovered protein an important tool for sleeping sickness research
8. Enzymes newly discovered role may make it target for arthritis treatment
9. Newly discovered genetic disease sheds light on bodys water balance
10. Newly recognized gene mutation may reduce seeds, resurrect plants
11. Drug discovery team to explore newly discovered deep-sea reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... of human beings. Now Tel Aviv University has developed ... lead to new antibiotics and powerful bacteria-based "green" pesticides ... by Prof. Eshel Ben-Jacob of Tel Aviv University,s Department ... Sirota-Madi says that their results deepen science,s knowledge of ...
... cell scientists, bioethicists and experts in law and public ... counter secrecy and self interest. The recommended measures focus ... of intellectual property related to stem cells. In ... British city where members first met in 2006lists five ...
... and monitoring Crohn,s disease. It is a stressful procedure in ... into the large intestine. MRI scans are therefore often used ... and how it is responding to treatment. TU Delft is ... an objective, quantitative method for assessing these MRI scans. The ...
Cached Biology News:The genius of bacteria 2Recommendations issued to counter patent, proprietary barriers to sharing stem cell data 2Recommendations issued to counter patent, proprietary barriers to sharing stem cell data 3EU grant for better monitoring of Crohn's disease using MRI 2EU grant for better monitoring of Crohn's disease using MRI 3
(Date:5/4/2015)... 4, 2015 /PRNewswire/ - The Fight Against Cancer ... to announce the formation of Turnstone Biologics Inc. ... for cancer that harness the patient,s own immune ... collaboration between the Children,s Hospital of ... University, the Ontario Institute for Cancer Research (OICR), ...
(Date:5/4/2015)... -- Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a ... needs in the areas of inflammation, oncology and biodefense, ... from three of its biodefense programs at the upcoming ... May 12-14, 2015 to be held at the America,s ... St. Louis MO 63101. The ...
(Date:5/4/2015)... GERMANTOWN, Md. , May 4, 2015   ... it will release first quarter 2015 financial results after ... will host a conference call that day at 5:30 ... general business update. The conference call may ... (International) and asking to join the "Intrexon Conference Call."  ...
(Date:5/1/2015)... 2015 OncoTAb, Inc., a ... company, announced that Pinku Mukherjee, Ph.D. has received the ... of Governors’ highest faculty honor. Mukherjee received the award, ... for her innovative research and development of cancer diagnostics ... a crowning moment in my scientific career,” said Mukherjee, ...
Breaking Biology Technology:Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 2Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 4Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 5Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 6Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 7Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 8Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 9Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 10Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 11Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 12Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2
... 2010 (BRONX, NY) By constructing a microscope ... cells, researchers at Albert Einstein College of Medicine ... that occur during one of the most important "trips" ... Ribonucleic acid (RNA) molecules from the nucleus into the ...
... Therapies, Inc., (VTI) is pleased to announce that ... in Riyadh, Kingdom of Saudi Arabia (K.S.A.) in the further ... L i VER Failure) clinical trial to the ... therapy product, ELAD®, can prevent deterioration of liver function and ...
... BASKING RIDGE, N.J., Sept. 16 Regado Biosciences, a ... with active control agents, announced that David J. Mazzo, ... UBS Global Life Sciences Conference.  Dr. Mazzo,s presentation will ... York City on Wednesday, September 22, 2010 at 8:00 ...
Cached Biology Technology:Nature study shows how molecules escape from the nucleus 2Nature study shows how molecules escape from the nucleus 3Vital Therapies Expands SILVER Trial to Saudi Arabia 2Vital Therapies Expands SILVER Trial to Saudi Arabia 3Vital Therapies Expands SILVER Trial to Saudi Arabia 4Regado Biosciences to Present at the UBS Global Life Sciences Conference on September 22, 2010 in New York City 2Regado Biosciences to Present at the UBS Global Life Sciences Conference on September 22, 2010 in New York City 3
CASPR (H-66)...
Homo sapiens toll interacting protein Antigen: Recombinant Protein...
Human SIGIRR MAb (Clone 162201)...
... EPS 1001 Power Supply, 1. 1000 ... voltage, constant current, and constant power ... for precision and reproducibility.Stores and recalls ... flatbed gels on Multiphor II ...
Biology Products: