Navigation Links
Newly created cancer stem cells could aid breast cancer research
Date:8/13/2007

CAMBRIDGE, Mass. (August 13, 2007) In some ways, certain tumors resemble bee colonies, says pathologist Tan Ince. Each cancer cell in the tumor plays a specific role, and just a fraction of the cells serve as queens, possessing the unique ability to maintain themselves in an unspecialized state and seed new tumors. These cells can also divide and produce the worker cells that form the bulk of the tumor.

These queens are cancer stem cells. Now the lab of Whitehead Member Robert Weinberg has created such cells in a Petri dish by isolating and transforming a particular population of cells from human breast tissue. After being injected with just 100 of these transformed cells, mice developed tumors that metastasized (spread to distant tissues).

The operational definition of a cancer stem cell is the ability to initiate a tumor, so these are cancer stem cells, declares Weinberg, who is also an MIT professor of biology.

Ince didnt set out to engineer these potent cells. As a post-doctoral researcher in the Weinberg lab and gynecologic pathologist at Brigham and Womens Hospital, he was simply trying to create breast cancer models that look like real human tumors under the microscope and behave like those seen in many patients.

In more than 90 percent of human breast tumors, cancer cells resemble those lining our bodys cavities. A trained pathologist can spot the similarities under a microscope. But the cancer cells previously engineered from normal breast cells for laboratory studies looked different. Ince suspected that researchers were transforming the wrong type of cells.

Now an independent investigator at Brigham and Womens Hospital and an instructor at Harvard Medical School, Ince developed a recipe for a new chemically defined culture medium and managed to grow a different type of human breast cell that ordinarily dies in culture. He transformed it into a cancer cell by inserting specific genes through a standard pr
'/>"/>

Contact: Alyssa Kneller
kneller@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. U of M researcher examines newly emerging deadly disease
4. Newly Discovered Compound Blocks Known Cancer-Causing Protein
5. Newly discovered pathway might help in design of cancer drugs
6. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
7. Newly discovered protein an important tool for sleeping sickness research
8. Enzymes newly discovered role may make it target for arthritis treatment
9. Newly discovered genetic disease sheds light on bodys water balance
10. Newly recognized gene mutation may reduce seeds, resurrect plants
11. Drug discovery team to explore newly discovered deep-sea reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... straw could be made quicker and cheaper thanks to ... , Researchers funded by the Biotechnology and Biological ... whose cell walls are more easily broken down to ... weaker than regular plants. , The discovery could ... from non-food crops become easier and cheaper to make. ...
(Date:9/22/2014)... Brain & Behavior Research Foundation today ... Investigator Grants valued at more than $12.7 ... promising young scientists. Recipients of the $30,000+/year, ... seek to identify causes, improve treatments and ... affect one in four people, including anxiety, ...
(Date:9/22/2014)... overweight, you may be at greater risk for ... and cancer, according to a new study by ... stress can trigger biological responses similar to the ... normal inflammation is an important part of our ... chronic and life-threatening diseases. , In a ...
Breaking Biology News(10 mins):Plant variants point the way to improved biofuel production 2Brain & Behavior Research Foundation awards 200 NARSAD Young Investigator grants 2Obesity and stress pack a double hit for health 2
... Miss. A summit that,s both scientific conference and ... front lines of fighting obesity and related metabolic diseases ... sponsored by the University of Mississippi Medical Center and ... the Jackson Convention Complex. Obesity and related ...
... National Institute of Food and Agriculture has awarded Virginia ... management of zoosporic pathogens and irrigation water quality to ... professor of plant pathology, physiology, and weed science in ... project,s director, explained that the study will help the ...
... The 2011 Croonian Lecture has been awarded to John ... biology and plant sciences. Ellis, an Emeritus Professor in ... Warwick in the UK, is the author of the ... his doctorate in 1960 from King,s College, London, and ...
Cached Biology News:Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 2Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 3Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 4Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 5$2.7 million research award to aid nursery, floriculture industry 2
(Date:9/20/2014)... 20, 2014 MediVet America ... a groundbreaking surgery at the specialized Wolvega Horse Clinic. ... digital flexor tendon was ruptured 90% and her deep ... is a death sentence for a horse. , The ... cell treatments . This revolutionary regenerative option for ...
(Date:9/19/2014)... yields to disease risks, the biological characteristics people care ... as for heightthe textbook example of a complex traitattributes ... by multiple genetic and environmental influences, making it challenging ... genes, geneticists typically mate two individuals that differ in ... mouseand then study their descendents, looking for genes that ...
(Date:9/19/2014)... to move data would consume much less power ... as chips, transistor counts rise. , Of the ... emitters, modulators, and detectors emitters are the ... optical chips is molybdenum disulfide (MoS2), which has ... atom-thick layer. Other experimental on-chip light emitters have ...
(Date:9/19/2014)... , Sept. 19, 2014  An entire month is ... inherited neuropathies – Charcot-Marie-Tooth disease (CMT) – a debilitating ... causing extreme muscle atrophy, weakness, and foot and hand ... and millions worldwide. CMT is a progressive disease, and ... legs, requiring mobility devices such as leg braces, wheelchairs ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... REDWOOD CITY, Calif., March 4 Maxygen, Inc.,(Nasdaq: ... the development of,improved protein drugs, today announced changes ... president in charge of global,business development and U.S. ... business officer. In addition, the company announced the,pending ...
... new independent non-executive directors added to Board with ... ... appointed independent non-executive Chairman, BRISBANE, Australia, March 4 ... John Lee and Robert Williamson to the Company,s Board as,independent ...
... Biosciences,(Nasdaq: MATK ) announced today that life,sDHA, its ... heart health, is available in new So,Good Omega DHA ... selling soymilk brand. Available in original or vanilla flavor, ... major retailers throughout,Canada., "So Good Omega DHA Soymilk ...
Cached Biology Technology:Maxygen Announces Management Changes 2Progen Expands Board of Directors 2Progen Expands Board of Directors 3Progen Expands Board of Directors 4Canada's Best-Selling Soymilk Now Available with Martek's life'sDHA 2Canada's Best-Selling Soymilk Now Available with Martek's life'sDHA 3
...
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531...
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... These skirted micro test tubes are ... of polypropylene, these tubes have uniform walls ... nonsterile, with separate O-ring screw caps. The ... and have an operating range from -55 ...
Biology Products: