Navigation Links
Newfound hijacked proteins linked to salmonella virulence
Date:8/23/2011

Scientists have discovered that bacteria like E. coli and Salmonella have a sneaky way of making minor alterations to their genes to boost their chances for infection.

It's a fascinating discovery made at Ohio State University, which is featured in the Aug. 14 issue of Nature Chemical Biology. This discovery shows how bacteria make tweaks in their genes, and their proteins to gain strength.

The team includes research scientist Herve Roy, who joined the University of Central Florida faculty at the College of Medicine this month. He co-authored the paper after conducting research in OSU Professor Michael Ibba's lab.

"Mother Nature tinkers a lot," Roy said from his new lab in Orlando. "Our recent findings illustrate that new proteins in living organisms often evolve from older pre-existing ones, and that evolution updates biochemical mechanisms of living cells by tweaking them a little by applying molecular patches."

The precise role of one protein in bacteria, EF-P, remains a mystery, but this team found that it plays an essential role in the virulence of Salmonella enterica typhimurium, a common foodborne pathogen causing diarrhea, fever, and abdominal cramps, and occasionally lifetime chronic arthritis. Salmonella also accounts for about 400 deaths each year in the United States.

EF-P is known to play a role in protein biosynthesis, which is a keystone mechanism present in all organisms. This process is the chain assembly line that decodes the blue prints stored in the genomes of living organisms, to make all the proteins necessary to sustain life.

The team's research identified a modification born by EF-P that acts as a molecular patch on protein synthesis. The patch seems to increase the bacteria's prowess. Interestingly, the modification on EF-P is made by a hijacked protein, normally involved in the protein synthesis machinery itself.

In the Aug. 14 issue of Nature Chemical Biology, R
'/>"/>

Contact: Zenaida Gonzalez Kotala
Zenaida.Kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hijacked supplies for pathogens
2. Saliva proteins could help detection of oral cancer
3. New lab manual focuses on essential methods for purifying and characterizing proteins
4. Proteins in sperm unlock understanding of male infertility says new study
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. Luminescence shines new light on proteins
7. Proteins strangle cell during division
8. Just a little squeeze lets proteins assess DNA
9. New technique is quantum leap forward in understanding proteins
10. Motor nerve targeting to limb muscles is controlled by ephrin proteins
11. JDRF-funded researchers discover proteins regulating human beta cell replication
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newfound hijacked proteins linked to salmonella virulence
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
(Date:7/11/2014)... of kidney injury related to the use of hydroxyethyl ... HES molecules, according to a report in Anesthesia ... Research Society (IARS). , The "total mass of HES ... human renal proximal tubule cells (PTCs), concludes the laboratory ... Hospital Wrzburg, Austria. Other factorssuch as differences in ...
(Date:7/11/2014)... is evidence that under the normal circumstances, ... development, maintain neuronal environment, and exhibit therapeutic ... neurodegenerative disease. Previous studies have found that ... after chemical induction have reduced viability, which ... Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... new study has revealed that mother birds can provide ... sired with their non-social partner (known as extra-pair offspring). ... birds commonly mate with males other than their social ... interloper,s ,extra pair, offspring often outperform their half brothers ...
... Technology for the first time have shown the earliest ... formation of bones, teeth and sea shells. ... capture a three-dimensional image of the nanoparticles that form ... greater understanding of the formation of bones, teeth and ...
... in US women of childbearing age, and is common in ... in the vagina is disrupted and replaced by an overgrowth ... increased risk for a variety of complications, such as preterm ... be prevented. Vitamin D may play a role in BV ...
Cached Biology News:Mothers give interloper's offspring a head start in life 2Mothers give interloper's offspring a head start in life 3Focus on the formation of bones, teeth and shells 2Vitamin D insufficiency linked to bacterial vaginosis in pregnant women 2
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
(Date:7/10/2014)... have shelled out for crude 3-D glasses, polarized ... experience. These basic devices, used to trick the ... soon be rendered obsolete with the introduction of ... researchers. , TAU doctoral students Yuval Yifat, Michal ... holography based on nanoantennas that could be used ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... (Pink Sheets: BSTC.PK) today announced that it sold,200,000 ... private placement,offering to an investment fund, at a ... to the Company of $2,100,000., About BioSpecifics ... biopharmaceutical company that has,developed and licensed injectable collagenase ...
... is seeking nominations for the Third Annual Greater ... March 18, 2008. Those,interested in nominating a company ... The four award categories are: Entrepreneurial, Best ... Award. Nominators will,be asked to submit documentation and ...
... multiplexing module, SANTA ROSA, Calif., Jan. 14 ... provider of optical components for industrial,applications, is to ... technology. The compact LED combining module, which utilizes,proprietary ... medical instrumentation. The ZoroLight LED module will be,on ...
Cached Biology Technology:Bookham to Enter Biomedical Illumination Market 2Bookham to Enter Biomedical Illumination Market 3
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... provide fast and reliable automation for ... drug development laboratories. Staccato Mini-Workstations offer ... automate basic liquid handling and material ... with either Caliper's time proven CLARA™ ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... Fermentation System to achieve high ... and maximum information output 4 ... precision with small-scale requirements provides users ... with E.coli, Pichia pastoris, yeast, fungi ...
Biology Products: