Navigation Links
Newfound hijacked proteins linked to salmonella virulence
Date:8/23/2011

Scientists have discovered that bacteria like E. coli and Salmonella have a sneaky way of making minor alterations to their genes to boost their chances for infection.

It's a fascinating discovery made at Ohio State University, which is featured in the Aug. 14 issue of Nature Chemical Biology. This discovery shows how bacteria make tweaks in their genes, and their proteins to gain strength.

The team includes research scientist Herve Roy, who joined the University of Central Florida faculty at the College of Medicine this month. He co-authored the paper after conducting research in OSU Professor Michael Ibba's lab.

"Mother Nature tinkers a lot," Roy said from his new lab in Orlando. "Our recent findings illustrate that new proteins in living organisms often evolve from older pre-existing ones, and that evolution updates biochemical mechanisms of living cells by tweaking them a little by applying molecular patches."

The precise role of one protein in bacteria, EF-P, remains a mystery, but this team found that it plays an essential role in the virulence of Salmonella enterica typhimurium, a common foodborne pathogen causing diarrhea, fever, and abdominal cramps, and occasionally lifetime chronic arthritis. Salmonella also accounts for about 400 deaths each year in the United States.

EF-P is known to play a role in protein biosynthesis, which is a keystone mechanism present in all organisms. This process is the chain assembly line that decodes the blue prints stored in the genomes of living organisms, to make all the proteins necessary to sustain life.

The team's research identified a modification born by EF-P that acts as a molecular patch on protein synthesis. The patch seems to increase the bacteria's prowess. Interestingly, the modification on EF-P is made by a hijacked protein, normally involved in the protein synthesis machinery itself.

In the Aug. 14 issue of Nature Chemical Biology, R
'/>"/>

Contact: Zenaida Gonzalez Kotala
Zenaida.Kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hijacked supplies for pathogens
2. Saliva proteins could help detection of oral cancer
3. New lab manual focuses on essential methods for purifying and characterizing proteins
4. Proteins in sperm unlock understanding of male infertility says new study
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. Luminescence shines new light on proteins
7. Proteins strangle cell during division
8. Just a little squeeze lets proteins assess DNA
9. New technique is quantum leap forward in understanding proteins
10. Motor nerve targeting to limb muscles is controlled by ephrin proteins
11. JDRF-funded researchers discover proteins regulating human beta cell replication
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newfound hijacked proteins linked to salmonella virulence
(Date:8/26/2015)... 26, 2015 The report "Multi-Factor Authentication ... Factor), Application (Travel & Immigration, Government, Banking, Defense, Commercial ... to 2020", published by MarketsandMarkets, Multi-Factor Authentication Market is ... at a CAGR of 17.7% between 2015 and 2020. ... igures spread through 169 P ...
(Date:8/20/2015)... 20, 2015   Sensory, Inc ., a ... user experience and security of consumer electronics through ... that its TrulySecure™ is the first ... be FIDO Certified™. The FIDO (Fast ... the FIDO UAF (Universal Authentication Framework) 1.0 specifications, ...
(Date:8/17/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... The new marketing campaign is being spearheaded by an ... ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ). ... driven marketing and brand awareness and has a client ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... the development of a type of esophageal cancer, known as ... These bacteria, which are called Helicobacter pylori, ... published in the October issue of Cancer Prevention Research, ... found that people who had H. pylori strains carrying a ...
... online this week in Nature that they ... to a gene associated with Crohn,s disease, an often ... link to immune cells intrigued researchers at Washington University ... others believe Crohn,s disease is caused by misdirected immune ...
... engineering plants capable of thriving in environments laden with ... October 2nd in Current Biology , a Cell ... in the earth,s crustcauses particular problems for farmers in ... the metal into a form that stunts the growth ...
Cached Biology News:H. Pylori bacteria may help prevent some esophageal cancers 2Form of Crohn's disease traced to disabled gut cells 2How to build crops that can beat aluminum's toxic effects 2
(Date:8/27/2015)... DIEGO , Aug. 27, 2015 HUYA ... annual meeting of the Japan Society of HTLV-1, held ... Institute Auditorium. The purpose of the Society is to ... as the development of medical technology and research related ... and welfare. "HUYA is proud to support ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Inc. Magazine ... States, ranking iLab Solutions as number 1,361 in growth for the three years through ... the top 0.1% fastest-growing privately held organizations in the country. , “We are ...
(Date:8/27/2015)... , Aug. 27, 2015 In ... by FedEx, UPS and The US Postal Service ... specimens classified as ,select agents, by the CDC, ... of handling these sensitive shipments. Marken ... transportation regulations, trained and certified personnel to ensure ...
(Date:8/26/2015)... , ... August 26, 2015 , ... ... announces today that a second US laboratory is to open in Manhattan, Kansas ... the continued partnership and long-term growth of research and development through collaboration with ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3
... DC New research shows that environmental gains derived ... part by the processes used to manufacture them. ... Journal of Industrial Ecology , a peer-reviewed journal owned ... of Forestry and Environmental Studies, highlights the need for ...
... FINANCIAL RESULTS Confirmation of Annual and Special ... - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ANP), ... a conference call discussing its,financial results for the third ... at 11:00 AM ET (8:00 AM Pacific)., The ...
... Preclinical Animal Data Demonstrates Selective Survival Advantage of ... Reduced Viral Loads, WASHINGTON and RICHMOND, Calif., ... ) announced today the presentation,of data demonstrating that ... HIV infection by treatment with zinc finger DNA-binding,protein ...
Cached Biology Technology:A need for improved efficiency in nanomanufacturing 2Notice of conference call and webcast 2Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 2Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 3Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 4Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 5
... The dotLab System brings together ... diffraction and immobilized capture surfaces. This ... simple technique for the detection of ... of fluorescent labels. , Protein-specific capture ...
... RY 13 5'G AATTC3' 3'CTTAA G5' Inactivation Conditions: ... ethanol precipitation. Storage Conditions: 10mM Tris-HCl (pH 7.5), ... X-100, 0.01% BSA, 50% glycerol. Shipping and Storage: ... Definition: One unit is defined as the amount ...
The HEPTEST assays provide a sensitive, simple, rapid, and convenient in vitro quantitation of heparin, low molecular weight heparins, and heparinoids in plasma and whole blood. Sample Type: wh...
... experiment based analysis package designed with easy ... and powerful functionality., Image acquisition interface is ... easy image capture. Sequential and dynamic ... Saturation Warning Single ...
Biology Products: