Navigation Links
Newborn screening increases survival outcome for patients with severe combined immunodeficiency
Date:1/27/2011

at every baby with SCID could be treated, and most likely, cured," said Fabio Candotti, MD, Vice Chair of the ASH Scientific Committee on Immunology and Host Defense and Head of the Disorders of Immunity Section in the Genetics and Molecular Biology Branch of the National Human Genome Research Institute at the National Institutes of Health. "Research that promotes early screening and diagnosis is vital for advancing the idea of universal adoption of testing."

The investigators conducted a retrospective cohort study by comparing the outcomes of 60 babies diagnosed at or before birth (between 1982 and 2010) with the outcomes of their relatives who also had the disorder using information gathered from databases from Great Ormond Street Hospital NHS Trust and Newcastle General Hospital in London, U.K.

Results from the study show that, in comparison to the family member with SCID, babies diagnosed at birth had a significantly decreased number of infections (89 percent versus 17 percent, respectively). Patients in the early-diagnosed group were also transplanted earlier and had a dramatically improved survival outcome following HSCT, regardless of donor match, conditioning regimen (chemotherapy or radiation given immediately prior to a transplant to help eliminate the patient's disease and to suppress immune reactions), or type of SCID.

The study showed that 35.4 percent (17 patients) of the 48 family members with SCID died before HSCT, and among the 31 of them who underwent HSCT, 38.7 percent (12 patients) died after the procedure. In comparison, only one patient in the early-diagnosed group died before HSCT and five patients (8.5 percent) died after HSCT. The transplant survival rate of the early-diagnosed group was 91.5 percent (p<.001) compared to 61.3 percent (p<.001) of their relatives with SCID.

"This is the first study that shows formal comparative data to demonstrate that newborn diagnosis can improve survival in SCID patients
'/>"/>

Contact: Lindsey Love
webmaster@hematology.org
202-552-4925
American Society of Hematology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method will triple amount of genetic information from newborn blood spot screenings
2. Newborns with low vitamin D levels at increased risk for respiratory infections
3. Allô allô! Moms voice plays special role in activating newborns brain
4. New UCLA study raises questions about genetic testing of newborns
5. Drug that helps adults addicted to opioid drugs also relieves withdrawal symptoms in newborns
6. Vitamin deficiency after weight loss surgery can cause vision loss in newborns
7. When do newborns first feel cold?
8. Bilingual babies: The roots of bilingualism in newborns
9. Researchers work on vaccine to improve immune system in newborns
10. New Web site promotes interoperable newborn screening data
11. Experimental treatment halts hypoxic-ischemic brain injury in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... cognitive function may play roles in one,s musical aptitude, ... timbre, tone durations, and formal structure in music. , ... that extremes in musical aptitude (extreme capacity/no capacity) are ... having moderate aptitude. , "This is a typical feature ... and it is influenced to varying degrees by environmental ...
(Date:9/15/2014)... is no published account where hippopotamuses are demonstrably shown ... of water. But if they can,t swim, how did ... widely accepted models for the methods, patterns, and timing ... Cyprus, Crete, and Madagascar) may need to be reconsidered. ... the mainland are not currently supported by positive ...
(Date:9/15/2014)... is available in German . ... is straightforward: it doubles, divides in the middle and ... long assumed that cells of the same kind are ... Bulgheresi,s team, University of Vienna, revealed that two non-model ... perceivable by the naked eye. These findings have been ...
Breaking Biology News(10 mins):Think big! Bacteria breach cell division size limit 2
... A new study suggests that jewel scarab beetles find ... that creates the 3D effects for the blockbuster movie ... Texas, the jewel scarab species Chrysina gloriosa ... ability could provide the beetles with a tremendous advantage, ...
... Lovn Centre for Marine Sciences at the University of Gothenburg ... in the Gullmarsfjord north of Gothenburg. The bacterium has been ... marine research center. Researcher Matthias Obst from the ... at the Sven Lovn Centre for Marine Sciences, a new ...
... Boston, MA A tobacco company,s new, dissolvable ... but which in some cases resembles popular candies--could lead ... new study from the Harvard School of Public Health ... for Disease Control and Prevention (CDC) and the Food ...
Cached Biology News:Beetles stand out using 'Avatar' tech 2Tobacco company's new, dissolvable nicotine products could lead to accidental poisoning 2
(Date:9/15/2014)... State University have developed a technique for controlling the ... voltages, opening the door to a new generation of ... hinges on the fact that the oxide "skin" of ... acts as a surfactant, lowering the surface tension ... researchers used a liquid metal alloy of gallium and ...
(Date:9/15/2014)... interdisciplinary team of researchers led by Northeastern University ... precise inter-nanotube junctions and a variety of nanocarbon ... facile and easily scalable, which will allow the ... networks for use in applications ranging from electronic ... from cars to sports equipment. , Their findings ...
(Date:9/15/2014)... , Sept. 15, 2014  iVinci Health LLC, ... comprehensive Patient Revenue Management system, branded as VisitPay®, has ... also announced the launch of a new extension to ... provides an easy and convenient way for patients to ... balances owed by them and their families. ...
(Date:9/15/2014)... Applied Silicone Corporation, a global ... medical device and critical healthcare market, introduces a ... medical device market. The Dual Matrix Gel ... silicone gel with improved fracture resistance, cohesive strength, ... of two crosslinked networks working in conjunction to ...
Breaking Biology Technology:Researchers control surface tension to manipulate liquid metals 2Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2
... Stock for Rights to Spinal Cells in Future, ... (Amex: CUR ), announces that Korean conglomerate, CJ,CheilJedang ... for the exclusive license to Neuralstem,s stem cell-products and,technology ... part of the agreement, CJ has purchased $2.5 million ...
... will support Phase 3 Trials for Crohn,s Disease, Pouchitis and ... ... 20 Ocera Therapeutics, a,biopharmaceutical company focused on the licensing, ... of,gastrointestinal and liver diseases, has announced the completion of a,$35.5 ...
... Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: NTII ), today ... Pharmaceuticals GmbH (Merz) for sales,by Merz and its ... Alzheimer,s disease for the quarter ended September 30,2007. ... royalty payments on sales of Memantine by Merz ...
Cached Biology Technology:Neuralstem Inc. Announces Strategic Investment by Korean CJ CheilJedang Corporation 2Neuralstem Inc. Announces Strategic Investment by Korean CJ CheilJedang Corporation 3Ocera Therapeutics Closes $35.5 Million Series C Financing 2Ocera Therapeutics Closes $35.5 Million Series C Financing 3Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine 2
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
Mouse monoclonal [CIG 3A11/5] to Cig2 (rating: *****) ( Abpromise for all tested applications)....
Rabbit polyclonal to CAMK 1D beta ( Abpromise for all tested applications). entrezGeneID: 57118 SwissProtID: Q5SQQ7...
Biology Products: