Navigation Links
Newborn screening increases survival outcome for patients with severe combined immunodeficiency
Date:1/27/2011

at every baby with SCID could be treated, and most likely, cured," said Fabio Candotti, MD, Vice Chair of the ASH Scientific Committee on Immunology and Host Defense and Head of the Disorders of Immunity Section in the Genetics and Molecular Biology Branch of the National Human Genome Research Institute at the National Institutes of Health. "Research that promotes early screening and diagnosis is vital for advancing the idea of universal adoption of testing."

The investigators conducted a retrospective cohort study by comparing the outcomes of 60 babies diagnosed at or before birth (between 1982 and 2010) with the outcomes of their relatives who also had the disorder using information gathered from databases from Great Ormond Street Hospital NHS Trust and Newcastle General Hospital in London, U.K.

Results from the study show that, in comparison to the family member with SCID, babies diagnosed at birth had a significantly decreased number of infections (89 percent versus 17 percent, respectively). Patients in the early-diagnosed group were also transplanted earlier and had a dramatically improved survival outcome following HSCT, regardless of donor match, conditioning regimen (chemotherapy or radiation given immediately prior to a transplant to help eliminate the patient's disease and to suppress immune reactions), or type of SCID.

The study showed that 35.4 percent (17 patients) of the 48 family members with SCID died before HSCT, and among the 31 of them who underwent HSCT, 38.7 percent (12 patients) died after the procedure. In comparison, only one patient in the early-diagnosed group died before HSCT and five patients (8.5 percent) died after HSCT. The transplant survival rate of the early-diagnosed group was 91.5 percent (p<.001) compared to 61.3 percent (p<.001) of their relatives with SCID.

"This is the first study that shows formal comparative data to demonstrate that newborn diagnosis can improve survival in SCID patients
'/>"/>

Contact: Lindsey Love
webmaster@hematology.org
202-552-4925
American Society of Hematology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method will triple amount of genetic information from newborn blood spot screenings
2. Newborns with low vitamin D levels at increased risk for respiratory infections
3. Allô allô! Moms voice plays special role in activating newborns brain
4. New UCLA study raises questions about genetic testing of newborns
5. Drug that helps adults addicted to opioid drugs also relieves withdrawal symptoms in newborns
6. Vitamin deficiency after weight loss surgery can cause vision loss in newborns
7. When do newborns first feel cold?
8. Bilingual babies: The roots of bilingualism in newborns
9. Researchers work on vaccine to improve immune system in newborns
10. New Web site promotes interoperable newborn screening data
11. Experimental treatment halts hypoxic-ischemic brain injury in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, ... the start of a new Phase III double blind, ... its novel formulation, CM-AT, on all children ages 3-8 ... its FDA Phase III double blinded clinical trial for ... low levels of the digestive enzyme chymotrypsin. This new ...
(Date:5/6/2015)... AVIV, Israel , May 6, 2015 ... world,s most established helmet producer, announced today that they ... Smart Helmet, the world,s first bio-sensing cycling helmet and ... be released in two new colors in order to ... for the product. In addition, LifeBEAM and Lazer announced ...
(Date:4/27/2015)... FORT LAUDERDALE, Fla. , Apr. 27, 2015 /PRNewswire/ ... provider of access control and security systems is pleased ... joined the company as a consultant and member of ... Bedore is widely known as a thought leader ... Socrates Distance Learning Technology Group, and has published studies ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... 100 marine scientists, policy makers and members of industry ... observatories monitoring Europe,s seas, at the Marine Board-ESF ... will give reliable, long-term data to underpin science and ... energy, shipping, as well as tourism and recreation. ...
... Irvine, Calif., Sept. 16, 2010 UC Irvine researchers ... and reproduce actually evolve over time. The findings, reported in ... the long-held belief that sexual beings evolve the same way ... genetic research for new pharmaceuticals and other products. "This ...
... daily life of morbidly obese woman but also decreases ... can not lose weight or can not maintain weight ... valuable procedure to help morbidly obese individuals lose weight, ... profiles and lower mortality. Now, researchers have found another ...
Cached Biology News:Watch your seas: Marine scientists call for European marine observatory network 2UCI scientists decode genomes of sexually precocious fruit flies 2Significant weight-loss from surgery decreases risk for cardiovascular disease in women 2
(Date:5/22/2015)... 2015 Charm Sciences, Inc. is ... Agriculture (USDA), Grain Inspection, Packers and Stockyards Administration ... Charm Sciences to monitor aflatoxin in grains utilizing ... ROSA FAST Aflatoxin Quantitative Test (solvent-based). , The ... uses Water Extraction Technology to extract aflatoxin from ...
(Date:5/21/2015)... N.J. (PRWEB) May 21, 2015 ... circulation audit and been admitted to BPA Worldwide ... BPA Worldwide will track audience data for Specialty ... coverage. , “By becoming a member of ... dedication to providing our clients with the most ...
(Date:5/21/2015)... -- Imagine being able to probe and ... others. Being able to read faces and enjoy genuine ... anticipate their thoughts and actions like never before. Use ... create unique abstract paintings and video, or, play a ... first-person-shooter as it creates action, dialog, and outcomes based ...
(Date:5/21/2015)... , May 20, 2015 Research and ... the addition of the "2015 Global Survey ... their offering. The primary goal of ... flow cytometry instruments and reagents. Key information the ... the selection of flow cytometers, predominantly used applications ...
Breaking Biology Technology:USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2
... ,Illinois Rising Stars, CHICAGO, Jan. 18 Brinks ... law firms in the United States, is,pleased to announce ... Lawyers" for 2008 in a survey conducted by Law ... "Rising Stars" in,Illinois., Meredith Martin Addy, chair of ...
... Jan. 18 Alba Therapeutics Corporation today,announced the ... and,Alliance Management. In this role, Ms. Perrow will ... program execution through,product approval and commercialization. Ms. Perrow ... management leadership team., "We are very pleased ...
... Jan. 18 In response to the,recent comments by ... lawsuits, CellCyte Genetics Corporation (the "Company") (OTC,Bulletin Board: CCYG) ... be shown to be so in a court of ... firm of Duane Morris LLP as its counsel and,will ...
Cached Biology Technology:Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Alba Therapeutics Appoints Wendy Perrow as its Vice President, Marketing and Alliance Management 2CellCyte Genetics Corp. Responds to Plaintiff Law Firm Press Releases 2CellCyte Genetics Corp. Responds to Plaintiff Law Firm Press Releases 3
... System is ideal for developing single and ... system contains the new, improved, and user ... user can design specific templates for commercial ... fully integrated graphing and data regression capabilities; ...
... Sweep- based acquision and ... evoked response type applications. Contains ... many flexible analysis functions including ... measurement plotting. Also includes many ...
EDG-6 Lysate Source: Cell Lysate Application: Western Blotting Control Form: IgG...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: