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New way to kill lymphoma without chemotherapy
Date:1/21/2013

ors on the lymphoma cell and manipulating cholesterol transport. In addition, patient samples analyzed by collaborators at Duke University for the study showed that lymphoma cells in patients had an overproduction of these HDL receptors compared to normal lymphocytes.

B-cell Lymphoma Most Common Lymphoma

The National Cancer Institutes reports that in 2012 there were about 70,000 new cases of non-Hodgkin lymphoma in the U.S. with nearly 19,000 deaths. About 90 percent of those new cases were B-cell lymphoma. Non-Hodgkin lymphoma is a cancer that starts in cells called lymphocytes, which are part of the body's immune system.

Why a Heart of Gold?

"Gold has a good track record of being compatible with biologic systems," Thaxton said.

Thaxton and Gordon are encouraged by their early data showing that the HDL nanoparticles do not appear toxic to other human cells normally targeted by HDLs, normal human lymphocytes or to mice. Also, because gold nanoparticles can be made in a discreet size and shape, they are excellent scaffolds for creating synthetic HDLs that closely mimic those found in nature.

"Like every new drug candidate, the HDL nanoparticle will need to undergo further testing," Thaxton noted.


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Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

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