Navigation Links
New way to control disease-spreading mosquitoes: Make them hold their urine
Date:3/3/2010

ITHACA, N.Y. Cornell researchers have found a protein that may lead to a new way to control mosquitoes that spread dengue fever, yellow fever and other diseases when they feed on humans: Prevent them from urinating as they feed on blood.

The work may lead to the development of new insecticides to disrupt the mosquito's renal system, which contributes to a mosquito's survival after feeding on blood.

Aedes aegypti mosquitoes transmit the virus that causes dengue fever, putting 40 percent of the world's population at risk of catching the disease, and causing 50 million to 100 million infections (22,000 deaths) annually. They pick up diseases when feeding on infected hosts and can then infect new hosts when they feed again. Currently, no vaccine or treatment protects against dengue, so the only way to stop its spread is by controlling mosquitoes.

But now, a Cornell study published in the March 4, 2010 issue of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology has identified a protein from the renal tubules of Aedes aegypti mosquitoes that appears to be involved in promoting urination as they feed on blood. When mosquitoes consume and process blood meals, they must urinate to prevent fluid and salt overloads that can kill them.

Also, "they have to undergo rapid urination when feeding, or they can't fly away," said Peter Piermarini, the paper's lead author and a postdoctoral research associate in the lab of Klaus Beyenbach, a professor of biomedical sciences in Cornell's College of Veterinary Medicine and the paper's senior author. "Too much weight will impair the mosquito's flight performance, like an aircraft with too much payload. [If they get too heavy,] they may become more susceptible to being swatted by their host or eaten by a predator," said Piermarini.

The researchers discovered a key protein expressed in the mosquito's renal system that contributes to urination. In lab experiments, Piermarini, Beyenbach and colleagues demonstrated that blocking the protein's function in the renal tubules with a drug reverses the enhanced rates of urination that would occur during blood feeding.

"Thus, blocking the function of this protein in natural populations of mosquitoes may limit their ability to survive the physiological stresses of a blood meal and to further transmit viruses," said Piermarini.

The Aedes aegypti renal system also serves as a valuable model for parts of the mammalian kidney, with similar cells in each system and possibly similar proteins, said the authors.


'/>"/>

Contact: Joe Schwartz
bjs54@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

Related biology news :

1. If you take simvastatin to control cholesterol, watch out for infection says new report
2. More than 1: Long-reigning microbe controlling ocean nitrogen shares the throne
3. Can a single layer of cells control a leafs size?
4. U-M researchers find key interaction that controls telomeres
5. Brain-controlled cursor doubles as a neural workout
6. Natural pest control saves coffee berry
7. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
8. A single atom controls motility required for bacterial infection
9. Johns Hopkins scientists discover a controller of brain circuitry
10. Study shows a key protein helps control blood pressure
11. New compounds may control deadly fungal infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/10/2016)... 10, 2016 --> ... report "Identity and Access Management Market by Component (Provisioning, ... Governance), by Organization Size, by Deployment, by Vertical, and ... MarketsandMarkets, The market is estimated to grow from USD ... 2020, at a Compound Annual Growth Rate (CAGR) of ...
(Date:3/9/2016)... GARDENS, Fla. , March 9, 2016 /PRNewswire/ ... management authentication and enrollment solutions, today announced the ... DigitalPersona ® Altus multi-factor authentication platform. ... and InfoSec managers to step-up security where it,s ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee ... Chuck has been a volunteer member of Committee since 1987. Since then, he ... of directors and treasurer and was chairman for both the program and exposition committees. ...
(Date:4/27/2016)... SPRING, Md. and RESEARCH TRIANGLE ... Therapeutics Corporation (NASDAQ: UTHR ) announced today ... Executive Officer, of United Therapeutics will provide an overview ... Bank 41 st Annual Health Care Conference. ... 5, 2016, at 10:00 a.m. Eastern Time, and can ...
(Date:4/27/2016)... ... April 27, 2016 , ... PathSensors, Inc., a ... Board. Dr. Lamka will assist PathSensors in expanding the use of the company‚Äôs ... the CANARY® test platform for the detection of harmful pathogens, including a number ...
(Date:4/27/2016)... MIAMI (PRWEB) , ... April 27, 2016 , ... ... a mutual endorsement of an Asia-Pacific Symposium as other research and development initiatives for ... of Santiago officials and top Global Stem Cells Group executives began meeting to establish ...
Breaking Biology Technology: