Navigation Links
New way to control disease-spreading mosquitoes: Make them hold their urine
Date:3/3/2010

ITHACA, N.Y. Cornell researchers have found a protein that may lead to a new way to control mosquitoes that spread dengue fever, yellow fever and other diseases when they feed on humans: Prevent them from urinating as they feed on blood.

The work may lead to the development of new insecticides to disrupt the mosquito's renal system, which contributes to a mosquito's survival after feeding on blood.

Aedes aegypti mosquitoes transmit the virus that causes dengue fever, putting 40 percent of the world's population at risk of catching the disease, and causing 50 million to 100 million infections (22,000 deaths) annually. They pick up diseases when feeding on infected hosts and can then infect new hosts when they feed again. Currently, no vaccine or treatment protects against dengue, so the only way to stop its spread is by controlling mosquitoes.

But now, a Cornell study published in the March 4, 2010 issue of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology has identified a protein from the renal tubules of Aedes aegypti mosquitoes that appears to be involved in promoting urination as they feed on blood. When mosquitoes consume and process blood meals, they must urinate to prevent fluid and salt overloads that can kill them.

Also, "they have to undergo rapid urination when feeding, or they can't fly away," said Peter Piermarini, the paper's lead author and a postdoctoral research associate in the lab of Klaus Beyenbach, a professor of biomedical sciences in Cornell's College of Veterinary Medicine and the paper's senior author. "Too much weight will impair the mosquito's flight performance, like an aircraft with too much payload. [If they get too heavy,] they may become more susceptible to being swatted by their host or eaten by a predator," said Piermarini.

The researchers discovered a key protein expressed in the mosquito's renal system that contributes to urination. In lab experiments, Piermarini, Beyenbach and colleagues demonstrated that blocking the protein's function in the renal tubules with a drug reverses the enhanced rates of urination that would occur during blood feeding.

"Thus, blocking the function of this protein in natural populations of mosquitoes may limit their ability to survive the physiological stresses of a blood meal and to further transmit viruses," said Piermarini.

The Aedes aegypti renal system also serves as a valuable model for parts of the mammalian kidney, with similar cells in each system and possibly similar proteins, said the authors.


'/>"/>

Contact: Joe Schwartz
bjs54@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

Related biology news :

1. If you take simvastatin to control cholesterol, watch out for infection says new report
2. More than 1: Long-reigning microbe controlling ocean nitrogen shares the throne
3. Can a single layer of cells control a leafs size?
4. U-M researchers find key interaction that controls telomeres
5. Brain-controlled cursor doubles as a neural workout
6. Natural pest control saves coffee berry
7. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
8. A single atom controls motility required for bacterial infection
9. Johns Hopkins scientists discover a controller of brain circuitry
10. Study shows a key protein helps control blood pressure
11. New compounds may control deadly fungal infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... 2016 A market that just keeps on ... the explosion in genomics knowledge. Learn all about it ... range of dynamic trends are pushing market growth and ... - pharmacogenomics - pathogen evolution - next generation sequencing ... greater understanding of the role of genetic material in ...
(Date:1/15/2016)... Puerto Rico , Jan. 15, 2016 ... big and small to find new ways to ensure ... culture. iOS and Android ... based on biometrics, transforming it into a hardware authorization ... that users swipe their fingerprint on their KodeKey enabled ...
(Date:1/11/2016)... 2016  higi, the leading retail and omni-channel community ... web and mobile, today announced it has closed ... investors. --> --> ... innovate higi,s health platform – its network of ... including expanding services and programs to retail partners ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... for more than 150 years, continues today to pursue the highest level of ... of analytical instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... cell treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols ... patients from around the world. , The new GSCG clinic is headed ...
(Date:2/10/2016)... Early-career researchers from Indonesia , ... Uganda and Yemen honored ... Indonesia , Nepal , ... are being honored for their accomplishments in nutrition, psychiatry, biotechnology, ... young women scientists who are pursuing careers in agriculture, biology and medicine ...
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal Inc., ... proprietary NeXosome® technology for early warning of adverse ... most recent study by Dr. Thomas McElrath ... Society for Maternal Fetal Medicine,s (SMFM) annual meeting held ... th , 2016.  The presentation reported initial positive ...
Breaking Biology Technology: