Navigation Links
New way to control disease-spreading mosquitoes: Make them hold their urine

ITHACA, N.Y. Cornell researchers have found a protein that may lead to a new way to control mosquitoes that spread dengue fever, yellow fever and other diseases when they feed on humans: Prevent them from urinating as they feed on blood.

The work may lead to the development of new insecticides to disrupt the mosquito's renal system, which contributes to a mosquito's survival after feeding on blood.

Aedes aegypti mosquitoes transmit the virus that causes dengue fever, putting 40 percent of the world's population at risk of catching the disease, and causing 50 million to 100 million infections (22,000 deaths) annually. They pick up diseases when feeding on infected hosts and can then infect new hosts when they feed again. Currently, no vaccine or treatment protects against dengue, so the only way to stop its spread is by controlling mosquitoes.

But now, a Cornell study published in the March 4, 2010 issue of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology has identified a protein from the renal tubules of Aedes aegypti mosquitoes that appears to be involved in promoting urination as they feed on blood. When mosquitoes consume and process blood meals, they must urinate to prevent fluid and salt overloads that can kill them.

Also, "they have to undergo rapid urination when feeding, or they can't fly away," said Peter Piermarini, the paper's lead author and a postdoctoral research associate in the lab of Klaus Beyenbach, a professor of biomedical sciences in Cornell's College of Veterinary Medicine and the paper's senior author. "Too much weight will impair the mosquito's flight performance, like an aircraft with too much payload. [If they get too heavy,] they may become more susceptible to being swatted by their host or eaten by a predator," said Piermarini.

The researchers discovered a key protein expressed in the mosquito's renal system that contributes to urination. In lab experiments, Piermarini, Beyenbach and colleagues demonstrated that blocking the protein's function in the renal tubules with a drug reverses the enhanced rates of urination that would occur during blood feeding.

"Thus, blocking the function of this protein in natural populations of mosquitoes may limit their ability to survive the physiological stresses of a blood meal and to further transmit viruses," said Piermarini.

The Aedes aegypti renal system also serves as a valuable model for parts of the mammalian kidney, with similar cells in each system and possibly similar proteins, said the authors.


Contact: Joe Schwartz
Cornell University

Related biology news :

1. If you take simvastatin to control cholesterol, watch out for infection says new report
2. More than 1: Long-reigning microbe controlling ocean nitrogen shares the throne
3. Can a single layer of cells control a leafs size?
4. U-M researchers find key interaction that controls telomeres
5. Brain-controlled cursor doubles as a neural workout
6. Natural pest control saves coffee berry
7. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
8. A single atom controls motility required for bacterial infection
9. Johns Hopkins scientists discover a controller of brain circuitry
10. Study shows a key protein helps control blood pressure
11. New compounds may control deadly fungal infections
Post Your Comments:
(Date:11/2/2015)... Calif. , Nov. 2, 2015  SRI International ... million to provide preclinical development services to the National ... contract, SRI will provide scientific expertise, modern testing and ... variety of preclinical pharmacology and toxicology studies to evaluate ... --> The PREVENT Cancer Drug Development Program ...
(Date:10/29/2015)... Oct. 29, 2015  The J. Craig Venter Institute ... "DNA Synthesis and Biosecurity: Lessons Learned and Options for ... Health and Human Services guidance for synthetic biology providers ... --> --> Synthetic ... the potential to pose unique biosecurity threats. It now ...
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... the remaining 11,000 post-share consolidation (or 1,100,000 pre-share ... "Series B Warrants") subject to the previously disclosed ... 23, 2015, which will result in the issuance ... to the issuance of such shares, there will ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh industrial processes, ... for in-line sensors can represent a weak spot where leaking process media is ... retractable sensor housings , which are designed to tolerate extreme process conditions. They ...
Breaking Biology Technology: