Navigation Links
New virus may pose risk to wild salmon
Date:7/9/2010

Farmed fish are an increasingly important food source, with a global harvest now at 110 million tons and growing at more than 8 percent a year. But epidemics of infectious disease threaten this vital industry, including one of its most popular products: farmed Atlantic salmon. Perhaps even more worrisome: these infections can spread to wild fish coming in close proximity to marine pens and fish escaping from them.

Heart and skeletal muscle inflammation (HSMI), an often fatal disease, was first detected in salmon on a farm in Norway in 1999, and has now been reported in 417 fish farms in Norway as well as in the United Kingdom. The disease destroys heart and muscle tissue and kills up to 20 percent of infected fish. Although studies have indicated an infectious basis, recent efforts to identify the pathogen causing the disease have been unsuccessful. Now, using cutting-edge molecular techniques, an international team led by W. Ian Lipkin, MD, the John Snow Professor of Epidemiology and director of the Center for Infection and Immunity at Columbia University's Mailman School of Public Health, has found evidence that the disease may be caused by a previously unknown virus. The newly identified virus is related but distinct from previously known reoviruses, which are double-stranded RNA viruses that infect a wide range of vertebrates.

The full study findings are published online in the publication PLoS One.

"Our data provide compelling evidence that HSMI is associated with infection with a new reovirus," says Gustavo Palacios, first author of the study and assistant professor of Epidemiology in the Center.

"While there is no evidence that this could spread to humans, it is a threat to aquaculture and it has the potential to spread to wild salmon," added Dr. Lipkin.

To identify the virus, the Columbia University investigators used 454 high throughput DNA sequencing and bioinformatics, including a new tool called Frequency Analysis of Sequence Data (FASD), pioneered by Raul Rabadan of Columbia's Department of Biomedical Informatics. Investigators in Norway and the U.S. then looked for viral sequences in heart and kidney samples from 29 salmon representing three different HSMI outbreaks and 10 samples from healthy farmed fish. Twenty-eight of the 29 (96.5%) known HSMI samples and none of the 10 healthy salmon samples were positive. The investigators also tested 66 samples obtained from wild salmon living in nine coastal rivers in Norway. The virus was detected in sixteen of these samples (24.2%), though generally in lower concentrations than found in ailing farmed fish.

"The speed of this process, and the enthusiasm on both sides of the Atlantic created a very fruitful collaboration," says Espen Rimstad, a professor at the Norwegian School of Veterinary Science in Oslo. "Using the expertise of our colleagues at Columbia in high throughput sequencing and advanced bioinformatics, we had within a few weeks the whole genome sequence of a hitherto unknown virus."

Additional research will be needed to confirm that the reovirus is the cause of HSMI. Meanwhile work has already begun in Norway to develop a vaccine to protect farmed Atlantic salmon.


'/>"/>

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related biology news :

1. Deadly rugby virus spreads in sumo wrestlers
2. Structures of important plant viruses determined
3. Research about plant viruses could lead to new ways to improve crop yields
4. World leaders in infectious diseases convene to discuss emerging global viruses
5. Study: Bird diversity lessens human exposure to West Nile Virus
6. Scripps research team solves structure of beneficial virus
7. Tick-borne encephalitis virus reveals its access code
8. Protein tubules free avian flu virus from immune recognition
9. Forced evolution: Can we mutate viruses to death?
10. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
11. Researchers recreate SARS virus, open door for potential defenses against future strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
Breaking Biology Technology: