Navigation Links
New variants found that indicate a predisposition to type 2 diabetes
Date:6/30/2010

ANN ARBOR, Mich.---An international team co-led by scientists from the University of Michigan have discovered 12 more regions on the genome with DNA variants that are associated with increased risk of type 2 diabetes, bringing the number to 38.

A variant is a place on a string of DNA where one of the "letters," or nucleotides, differs between people. At most places along the DNA, any two people will have the same letter. The variable places in the DNA are important because some variants can increase predisposition to disease and other conditions, or offer drug targets.

Researchers also wanted to know if people who hadn't yet developed type 2 diabetes but did have the diabetes variant showed elevated blood glucose levels, a main predictor of diabetes, said study co-leader Laura Scott, associate research scientist at the U-M School of Public Health.

"What our study suggests is that many of these variants are associated with changes in glucose levels long before people get diabetes," said study co-leader Michael Boehnke, professor of biostatistics at U-M's School of Public Health.

One surprising finding was that the regions with diabetes variants also seemed to be associated with nonrelated diseases. Researchers looked at a database containing a list of all the genome wide association (GWA) studies to date. They examined regions where there was a type 2 diabetes association to see if there was an increased association for other diseases and traits that have been studied thus far.

"We saw surprising overlap or predisposition of not just related but also apparently unrelated traits," said Boehnke, who suggested that there could be master regulators in the genome that play a role in many different aspects of physiology and health.

The next step is to take the research beyond GWA, which looks at a few million places on the genome, into genome sequencing. Genome sequencing will allow researchers to assay most of the 3 billion base pairs in the human genome and find less common variants that might be associated with disease. Currently, a three-study international team co-led by the Michigan group is sequencing 2,650 individuals with and without diabetes, in what is one of the largest sequencing projects underway in the world. Scott and Boehnke hope to have information about the variants present in individuals with and without diabetes within the next year-and-a-half.


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-764-1552
University of Michigan
Source:Eurekalert

Related biology news :

1. Autism genome project identifies genetic variants that may make people susceptible to disorder
2. Newly discovered gene variants lead to autism and mental retardation
3. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
4. New gene variants associated with glucose, insulin levels, some with diabetes risk
5. Identification of genetic variants affecting age at menopause could help improve fertility treatment
6. Common gene variants influence risk factor for sudden cardiac death
7. Common gene variants increase risk of hypertension, may lead to new therapies
8. International study identifies gene variants associated with early heart attack
9. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
10. New gene variants present opportunities in nutrigenomics
11. Study identifies genetic variants giving rise to differences in metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
(Date:6/23/2016)... SAN FRANCISCO , June 22, 2016  Amgen ... platinum sponsorship of the QB3@953 life sciences ... improve human health. The shared laboratory space at QB3@953 ... startups overcome a key obstacle for many early stage ... As part of the sponsorship, Amgen launched two "Amgen ...
Breaking Biology Technology: