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New vaccine to assist worldwide eradication of polio
Date:12/14/2010

Scientists at the University of Leeds are joining the global fight to eradicate polio by developing a new type of vaccine that can trick the body to develop immunity against the disease.

The project has been awarded $500,000 from the Bill and Melinda Gates Foundation, through the World Health Organisation, and aims to be effective against all polio subtypes.

Led by Professor Dave Rowlands and Dr Nicola Stonehouse from the University's Faculty of Biological Sciences, the research team will design a replica virus particle that looks and behaves like the real virus, but is actually an empty protein shell.

The researchers believe the hoax virus will trigger the body's immune system, but because it does not contain the genetic blueprint that replicates the virus inside the body, has no chance of causing or helping to spread the disease.

"This is an entirely new strategic approach against polio," says Dr Stonehouse. "This project is not about improving the efficiency of the current types of vaccine. Our intention is to design and produce a replica virus particle that carries no RNA cargo. This means it will be entirely safe to use as it can't ever cause the disease, and unlike current vaccines, can be produced without needing to grow large amounts of the infectious virus."

The team, led by Leeds, brings together researchers from Harvard University, the University of Oxford and the UK's National Institute for Biological Standards and Control (NIBSC), a centre of the Health Protection Agency. The first stage of the research will focus on proving that that the new approach is viable against the virus.

Current polio vaccines in use around the world are either delivered orally or injected, but contain either a weakened form of the virus, or an inactivated virus to kickstart the immune response. Whilst these have been extremely successful in reducing polio globally, the virus persists in several countries and unexpected outbreaks still
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Contact: Dr Nicola Stonehouse
n.j.stonehouse@leeds.ac.uk
44-113-343-3102
University of Leeds
Source:Eurekalert  

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