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New vaccine developed for preventing 'uncommon cold' virus
Date:2/2/2009

FAIRFAX, Va. Common colds typically cause a week of sneezing, aches and pains and then fade away leaving only a sore nose and a few used sick days behind. But what if that cold turned out to be something more?

Human adenovirus type-3 is known as the "uncommon cold" because the infection's symptomsrunny nose, sore throat, cough and feverare eerily similar to those of the common cold which is caused by the rhinovirus. The difference is that, unlike the common cold, the symptoms of the uncommon cold are typically much more severe and can even be fatal.

Adenovirus-3 thrives in nations with dense urban populations and has recently become prevalent in southern China and neighboring countries. It may also emerge in less likely locales with dense populations, such as schools, health care facilities and military training bases in the U.S.

Determined to stamp out this devastating infection, researchers from George Mason University, the University of Hong Kong, Guangzhou Children's Hospital, the South China Institute of Technology and the Graduate School of Chinese Academy of Sciences have developed a DNA-based vaccine that has effectively protected mice from the infection.

Their findings will appear in the February 18, 2009 print edition of the journal Vaccine and are currently available online (http://dx.doi.org/10.1016/j.vaccine.2008.12.039).

"Further study is required, but we hope that in the future, this simple, stable and inexpensive vaccine can be mass-produced and made available to susceptible populations," says Donald Seto, associate professor in George Mason University's Department of Bioinformatics and Computational Biology, the only U.S.-based researcher involved in the study. "Affordability is a key factor since these regions are generally economically depressed."

According to the Centers for Disease Control and Prevention (CDC), the hum
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Contact: Marjorie Musick
mmusick@gmu.edu
703-993-8781
George Mason University
Source:Eurekalert

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