Navigation Links
New vaccine developed for preventing 'uncommon cold' virus
Date:2/2/2009

FAIRFAX, Va. Common colds typically cause a week of sneezing, aches and pains and then fade away leaving only a sore nose and a few used sick days behind. But what if that cold turned out to be something more?

Human adenovirus type-3 is known as the "uncommon cold" because the infection's symptomsrunny nose, sore throat, cough and feverare eerily similar to those of the common cold which is caused by the rhinovirus. The difference is that, unlike the common cold, the symptoms of the uncommon cold are typically much more severe and can even be fatal.

Adenovirus-3 thrives in nations with dense urban populations and has recently become prevalent in southern China and neighboring countries. It may also emerge in less likely locales with dense populations, such as schools, health care facilities and military training bases in the U.S.

Determined to stamp out this devastating infection, researchers from George Mason University, the University of Hong Kong, Guangzhou Children's Hospital, the South China Institute of Technology and the Graduate School of Chinese Academy of Sciences have developed a DNA-based vaccine that has effectively protected mice from the infection.

Their findings will appear in the February 18, 2009 print edition of the journal Vaccine and are currently available online (http://dx.doi.org/10.1016/j.vaccine.2008.12.039).

"Further study is required, but we hope that in the future, this simple, stable and inexpensive vaccine can be mass-produced and made available to susceptible populations," says Donald Seto, associate professor in George Mason University's Department of Bioinformatics and Computational Biology, the only U.S.-based researcher involved in the study. "Affordability is a key factor since these regions are generally economically depressed."

According to the Centers for Disease Control and Prevention (CDC), the human adenovirus was first seen in the 1950s and is associated with a wide spectrum of illnesses including conjunctivitis, upper respiratory infections, pneumonia and gastrointestinal disease. More than 50 unique serotypes of the virus have been identified, with even more expected to be isolated.

Adenovirus outbreaks are difficult to control because the virus can live for weeks on environmental surfaces and spreads quickly through direct contact, aerosol and contaminated drinking water.

Although the disease is relatively rare in the U.S., CDC records indicate that it has made several appearances here with devastating results. In 2000, four children died during an outbreak of adenovirus type-7 that occurred at a long-term care facility in Iowa, and nine patients died when adenovirus type-14 appeared as epidemics in Oregon, Texas and Washington in 2007.

Seto hopes that this new vaccine will serve as a model that allows his team to target the remaining strains of the virus.

"The immediate impact is the production and distribution of a low-cost, stable vaccine for adenovirus-3," says Seto. "The outstanding question is, if all of the strains are so similar, why are they restricted to certain tissues, like only the eyes or the respiratory tract? That's what we'll try to figure out next."


'/>"/>

Contact: Marjorie Musick
mmusick@gmu.edu
703-993-8781
George Mason University
Source:Eurekalert

Related biology news :

1. Possible hepatitis C vaccine
2. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
3. New nanoparticle vaccine is more effective but less expensive
4. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
5. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
6. An Alzheimers vaccine?
7. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. HIV isolate from Kenya provides clues for vaccine design
10. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
11. Vaccine for Ebola virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: