Navigation Links
New understanding of protein's role in brain
Date:3/25/2010

This release is available in French.

How do we process thoughts and store memories? A team of researchers headed by Dr. Nahum Sonenberg of McGill's Department of Biochemistry and Goodman Cancer Centre has discovered that brains in mammals modify a particular protein in a unique way, which alters the protein's normal function. This discovery represents an important step in understanding how our brains work.

When our memories are being formed, nerve cells, or neurons, communicate with each other through electrical impulses at specialized connections. To strengthen these connections, the neurons require new proteins key molecules needed for all forms of cellular activity. The protein in question, 4E-BP2, controls the process of producing new proteins in the nervous system.

This process, known as protein synthesis or translation, is the major focus of research in Sonenberg's laboratory. Before the team's discovery, no one knew 4E-BP2 could be chemically altered in such a manner as the team described in its work, much less that this could have an effect on neuron function.

According to the lead researcher Dr. Michael Bidinosti, a recent graduate from Sonenberg's laboratory, "we found a modification to a protein that controls the cellular protein-synthesis machinery. This modification seems to affect the ability of nerve cells to communicate with each other and is thought to be part of the processes underlying memory."

He explains that study of protein synthesis and of memory are increasingly converging fields, and that the team's research is an important achievement in this arena. Collaboration was critical to the discovery as the team includes researchers from the Universit de Montral, the Montreal Neurological Institute, the University of Toronto, Baylor College of Medicine in Houston, and the University of Bergen in Norway.

"Better understanding of protein synthesis in the brain is crucial to the advancement of neuroscience, particularly as researchers discover that altered proteins may have a direct impact on the memory process," says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research (CIHR) Institute of Neurosciences, Mental Health and Addiction. "CIHR hopes that these new findings will lead to more research aimed at ultimately solving memory loss issues."


'/>"/>

Contact: William Raillant-Clark
william.raillant-clark@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related biology news :

1. LSUHSC research increases understanding of drug metabolism
2. Model may offer better understanding of embryonic development
3. ARS study provides a better understanding of how mosquitoes find a host
4. Biologists use mathematics to advance our understanding of health and disease
5. Understanding global climate change through new breakthroughs in polar research
6. Entomologist May R. Berenbaum wins Public Understanding of Science Award
7. Research project yields better understanding of the defective protein that causes cystic fibrosis
8. Understanding apples ancestors
9. New clues emerge for understanding morphine addiction
10. New understanding of how to prevent destruction of a tumor suppressor
11. Scientists gain new understanding of disease-causing bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... 15, 2016 Advancements in biometrics ... wellness and wellbeing (HWW), and security of ... new passenger vehicles begin to feature fingerprint ... heart beat monitoring, brain wave monitoring, stress ... and pulse detection. These will be driven ...
(Date:12/12/2016)... , Dec. 12, 2016  Researchers at ... possibilities for graphene by combining the material with ... highly sensitive pressure detector able to sense pulse, ... a small spider.  The research ... can be read here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... PUNE, India , December 7, 2016 According to ... NLP, Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End ... size is estimated to grow from USD 6.72 Billion in 2016 to USD ... Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... ... 2017 , ... G&L Scientific Inc, a leading provider of ... has announced the opening of new offices in Cambridge, Massachusetts, strengthening and improving ... is the latest step in G&L’s expansion of its global clinical consulting services ...
(Date:1/21/2017)... -- Bioptix, Inc. (Nasdaq: BIOP ... 14, 2017 the Board of Directors of the Company ... certain employees associated with the September 2016 acquisition of ... on January 16, 2017 and terminations are expected to ... severance benefits in certain circumstances of up to one ...
(Date:1/20/2017)... Stock-Callers.com explores the Biotech industry ... most recent performances of select equities. In this morning,s ... ), Abeona Therapeutics Inc. (NASDAQ: ABEO ), ... Sage Therapeutics Inc. (NASDAQ: SAGE ). According ... global Biotech market size is expected to reach $604.40 billion by 2020 due ...
(Date:1/19/2017)... 2017 Research and Markets has announced the ... Cancer Type, Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" ... ... market is projected to reach $15,737 million by 2022 from $6,521 ... 2022. Omic technologies segment accounted for more than ...
Breaking Biology Technology: