Navigation Links
New understanding about mechanism for cell death after stroke leads to possible therapy
Date:11/22/2009

s."

While the detailed mechanisms by which activation of SREBP-1 leads to brain cell death remain to be established, the researchers discovered a way to inhibit SREBP-1 and thereby significantly reduce cell death.

"We developed a drug that can stabilize Insig-1, which in turn inhibits the activity of SREBP-1," says Dr. Max Cynader, co-lead on the study, a Canada Research Chair in Brain Development, and the Director of the Brain Research Centre. "By doing so, we were able to prevent cell death."

The researchers also found that the drug works post-stroke in animal models. "When we administered it post-stroke, there was less brain cell damage 30 days later than compared to controls," says Dr. Wang. "This is important because previous studies focused on blocking the NMDA receptors in order to prevent cell death, but this approach didn't work because it affected normal cell function and had a relatively short therapeutic window. The drug we studied works downstream of NMDA receptors and appears to have less detrimental side effects with a much improved therapeutic window."

Further investigations will help researchers understand how SREBP-1 causes cell death and to further determine efficacy of the drug. As well, because of the protein's connection to cholesterol synthesis and other cellular functions, further investigations may reveal if it has a role in other neurological disorders, such as ALS, and whether the drug might be effective for those conditions as well.


'/>"/>

Contact: Melissa Ashman
mashman@brain.ubc.ca
604-827-3396
University of British Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. Understanding hypertension in African Americans proves elusive
3. Systems Biology poised to revolutionize the understanding of cell function and disease
4. Gregory Hannon wins 2007 Paul Marks Prize for contributions to understanding and treating cancer
5. Understanding, combating foodborne pathogens E. coli 0157 and salmonella
6. Researchers discover important tool in understanding differentiation in human embryonic stem cells
7. Atmospheric measuring device for understanding smog formation
8. Researchers move 2 steps closer to understanding genetic underpinnings of autism
9. Scientists expand understanding of how river carbon impacts the Arctic Ocean
10. From delicious to death: Understanding taste
11. USP Convention and Chinese Pharmacopoeia Commission sign Memorandum of Understanding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 31, 2015   Guidepoint , a leading global ... Post-Surgical Pain Management TRACKER, part of the Guidepoint ... in the medical device and therapeutics markets. The Post-Surgical ... treatment volumes, market share, and adoption rates across three ... joint surgery. The Post-Surgical Pain Management TRACKER ...
(Date:3/24/2015)... Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of ... report to their offering. This report analyzes the ... the following Segments: Face Biometrics, and Voice Biometrics. The report provides ... Japan , Europe , ... Africa , and Latin America ...
(Date:3/23/2015)... 2015   HOYOS Labs , a leading global ... that the Company will demonstrate multiple biometrics-based technologies under ... at Connect:ID on March 23 through 25, 2015, in ... highlight the IEEE Biometric Open Protocol Standard; free biometrics-based ... access control system. BOPS was invented by HOYOS Labs ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... Geology: researchers experience an earthquake while studying the ... tooth crown height, is used to track aridity patterns; ... ecosystem is presented; researchers chronicle the discovery of a ... wave-energy environments on Earth; and a change in volcanic ...
... like populations of human beings, clusters of living ... qualities. Traditional analytic techniques however evaluate cells in ... offer valuable clues concerning health and disease. ... and her colleagues at Arizona State University,s Biodesign ...
... a series of papers published in chemistry and chemical ... have advanced the case for extracting carbon dioxide directly ... The technique might initially be used to supply carbon ... algae or enhanced oil recovery. But the method could ...
Cached Biology News:Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 2Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 3Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 4Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 5Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 6Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 7Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 8Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 9Breakthrough technology focuses in on disease traits of single cells 2Breakthrough technology focuses in on disease traits of single cells 3Breakthrough technology focuses in on disease traits of single cells 4Study shows economic feasibility for capturing carbon dioxide directly from the air 2Study shows economic feasibility for capturing carbon dioxide directly from the air 3Study shows economic feasibility for capturing carbon dioxide directly from the air 4
(Date:4/16/2015)... 17, 2015 Spirax Sarco, the ... released their newly designed, state-of-the-art website in the ... website effectively promotes the Spirax Sarco brand, company ... information that a site visitor might be looking ... capabilities, industries serviced, the latest company news, careers, ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... April 16, 2015 Capillus, LLC ... and physician network in Europe and Asia. The ... appointed Fernando Bermúdez, former Business Development Director of ... industry veteran, Mr. Bermúdez’s professional achievements include increasing ... Spain, while also penetrating the Portuguese marketplace with ...
(Date:4/16/2015)...  Schulman Associates IRB, Inc., the industry-leading central IRB ... lease on Laboratory Drive in the heart of ... location will house review board and service staff, which ... and customer service to clients. CBRE ... the deal, while Capital Associates Management, LLC represented the ...
Breaking Biology Technology:Spirax Sarco website has a new look 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Schulman IRB to Open Office in Research Triangle Park, N.C. 2
... insight, discipline, and a relentless focus on developing technology, ... high-value company by defining a big problem with a ... products. Neah Power Systems is a company ... , ,Neah is a successful fuel cell company ...
... announced today it has been chosen again to ... Wisconsin-Madisons Camp Randall Stadium and Kohl Center arena. The ... South Dakota-based company in the early 1990s. The value ... to be complete before the start of the 2004 ...
... today that it is the only Wisconsin member of North ... United Training is a consortium of independently owned ... who have met an extremely high set of standards to ... to qualify for membership, Inacom was recognized by its peers, ...
Cached Biology Technology:Neah Power Systems A seed stage venture capital model 2Neah Power Systems A seed stage venture capital model 3Neah Power Systems A seed stage venture capital model 4Neah Power Systems A seed stage venture capital model 5Daktronics to provide Camp Randall and Kohl Center with scoreboards, display systems 2
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
High affinity antibodies recognizes HSP70 protein from human cardiac tissue. Could be used for Westerb blotting application, ELISA....
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
... Yellow crystalline solid. PROTECT FROM LIGHT. Useful in cell ... Purity: ≥98% by TLC. Soluble in DMSO ... of a 10 mM stock in DMSO is recommended. ... H 2 O with rapid mixing (e.g. 10 μl ...
Biology Products: