Navigation Links
New ultrasound device may add in detecting risk for heart attack, stroke
Date:4/24/2014

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke.

At issue is the plaque that builds up in arteries as we age. Some types of plaque are deemed "vulnerable," meaning that they are more likely to detach from the artery wall and cause heart attack or stroke.

"Existing state-of-the-art technologies are capable of determining if plaque is present in the arteries, but can't tell whether it's vulnerable. And that makes it difficult to assess a patient's risk," says Dr. Paul Dayton, co-author of a paper on the new device and professor in the joint biomedical engineering department at NC State and Chapel Hill. "Our goal was to develop something that could effectively identify which plaques are vulnerable."

There are two ultrasound techniques that can help identify vulnerable plaques, but both depend on the use of contrast agents called "microbubbles."

The first technique is to identify "vasa vasorum" in arteries. These are clusters of small blood vessels that often infiltrate arterial plaque, and which are considered indicators that a plaque is vulnerable. When microbubbles are injected into an artery, they follow the flow of the blood. If vasa vasorum are present, the microbubbles will flow through these blood vessels as well, effectively highlighting them on ultrasound images.

The second technique is called molecular imaging, and relies on the use of "targeted" microbubbles. These microbubbles attach themselves to specific molecules that are more likely to be found in vulnerable plaques, making the plaques stand out on ultrasound images.

"The problem is that existing intravascular ultrasound technology does not do a very good job in detecting contrast agents," says Dr. Xiaoning Jiang, an NC State associate professor of mechanical and aerospace engineering, an adjunct professor of biomedical engineering and co-author of the paper.

"So we've developed a dual-frequency intravascular ultrasound transducer which transmits and receives acoustic signals," Jiang says. "Operating on two frequencies allows us to do everything the existing intravascular ultrasound devices can do, but also makes it much easier for us to detect the contrast agents or microbubbles used for molecular imaging and vasa vasorum detection."

The prototype device has performed well in laboratory testing, but the researchers say they are continuing to optimize the technology. They hope to launch pre-clinical studies in the near future.


'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Related biology news :

1. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
2. Acoustic tweezers capture tiny creatures with ultrasound
3. Preclinical studies use specialized ultrasound to detect presence of cancer
4. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
5. Springer will collaborate with the Italian Society for Ultrasound in Medicine and Biology
6. Ultrasound reveals autism risk at birth
7. Texas A&M research contributes to improved ultrasound imaging
8. Measuring ultrasound for better treatment of muscle injuries
9. UF researcher shows hawkmoths use ultrasound to combat bats
10. Ultrasound patch heals venous ulcers in human trial
11. Ultrasound, nanoparticles may help diabetics avoid the needle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New ultrasound device may add in detecting risk for heart attack, stroke
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... Optimove , provider of the ... as 1-800-Flowers and AdoreMe, today announced two new ... Using Optimove,s machine learning algorithms, these features allow ... recommendations to their customers based not just on ... intent drawn from a complex web of data ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... Aug. 11, 2017  Market researcher Kalorama ... Times article regarding the telemedicine market.  The ... Kalorama Information.  The article, "Heart and ...  used information from Kalorama Information,s Remote ... Telemedicine Market  (Sleep, Diabetes, Vital Signs ...
(Date:8/11/2017)... (PRWEB) , ... August 11, 2017 , ... ... food production, and, in particular, more natural alternatives to synthetic ingredients,” said Matt ... of Third Wave, with the established manufacturing presence and know-how of Biorigin will ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... medicine applications in the clinic is here. The team at Capricor Therapeutics, Inc. ... conditioned medium for clinical studies. , Dr. Travis Antes, head of analytical ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... international biomedical optics laboratories — the Wellman Center for Photomedicine, the Manstein Lab ... Lübeck and the Beckman Laser Institute at University of California, Irvine — and ...
Breaking Biology Technology: