Navigation Links
New type of human stem cell may be more easy to manipulate
Date:6/8/2010

amming adult cells and have many of the characteristics of human ECSs, including resistance to manipulation in cultures containing the growth factor LIF, which is used in the creation of mouse ESCs.

The resulting cells visibly resembled mouse ESCs and proved amenable to a standard gene manipulation technique that exchanges matching sequences of DNA, allowing the targeted deactivation or correction of a specific gene. The ability to manipulate these new cells depended on both the continued presence of LIF and expression of the five genes that are used in reprogramming adult cells into iPSCs. If any of those factors was removed, these hLR5- (for human LIF and five reprogramming factors) iPSCs reverted to standard iPSCs.

"Genetic changes introduced into hLR5-iPSCs would be retained when they are coverted back to iPSCs, which we then can use to generate cell lines for future research, drug development and someday stem-cell based gene-correction therapies," says Geijsen. He is an assistant professor of Medicine at Harvard Medical School and a principal faculty member of the Harvard Stem Cell Institute.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Forsyth scientists support the Human Microbiome Project
2. Some like it hot: Site of human evolution was scorching
3. East-African human ancestors lived in hot environments, says Caltech-led team
4. Scientists discover ancient viral invasion that shaped human genome
5. Innovative research reawakens human memories through intelligent textiles
6. New culture dish could advance human embryonic stem cell research
7. Powerful genome barcoding system reveals large-scale variation in human DNA
8. European Society of Human Reproduction and Embryology Annual Meeting
9. Early human habitat was savanna, not forest
10. UCI researchers create retina from human embryonic stem cells
11. Discovery of stem cell illuminates human brain evolution, points to therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... tube connectors, designed by an international standards process, will ... According to an invited review published in the OnlineFirst ... NCP ), the official journal of the American Society ... will greatly reduce the occurrence of misconnection that can ... connectors, which are used to join medical devices, components, ...
(Date:8/21/2014)... the pancreas digesting itself resulting in severe abdominal pain, ... around 20,000 patients are diagnosed with the disease resulting ... treatment is restricted to intravenous fluid and nutritional support. ... Life Sciences, who led the research, said "The major ... stones and excessive alcohol intake combined with a high ...
(Date:8/20/2014)... University of Tennessee, Knoxville, research finds life can persist ... professor was part of a team that examined waters ... Antarctic ice sheet and found the extreme environment supports ... by Jill Mikucki and her colleagues has implications for ... in the solar system. The findings are published in ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2
... and Canadian research team surveying mercury contamination in fish ... Canada has identified five "hotspots" where concentrations of the ... The team focused on levels of the potent neurotoxin ... took into account contamination in other fish, birds, and ...
... of thousands of heart patients to have high-tech devices implanted ... expensive devices are designed to shock damaged hearts back into ... 300,000 Americans each year. , But a new study finds ... ICDs, a large number won't -- and a simple heart-rhythm ...
... from grain, but the U.S. Department of Energy (DOE) would ... alternatives, such as paper pulp, sawdust, straw and grain hulls. ... by analyzing the DNA of a bacterium that can break ... also found in forestry by-products (including paper) and waste feedstocks. ...
Cached Biology News:Hotspots of mercury contamination identified in eastern North America 2Are one-third of costly implanted heart devices unnecessary? New study suggests yes 2Are one-third of costly implanted heart devices unnecessary? New study suggests yes 3McBride shows DNA detective work with paper-eating bacteria that 'glide' 2McBride shows DNA detective work with paper-eating bacteria that 'glide' 3
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
(Date:8/21/2014)... YORK , Aug. 21, 2014 Mathematic studies ... Harvard University , and funded by the Jeffrey ... cells within tumors can be visually identified for elimination. These ... growth. The study, which shows a topological map of what ... time in cancer research, for while tumor cells can be ...
(Date:8/21/2014)... 2014 Pursuit Solutions ( http://www.pursuit-solutions.com ... and services for Life Sciences sales and marketing ... of New Commercial Sales Models” by Peter Robinson, ... The article examines some innovative models used to ... tested in the pharmaceutical market. Robinson grades the ...
(Date:8/21/2014)... 2014 On Wednesday of last week RENU ... Redox Signaling molecules, became available for purchase in Australia and ... way that RENU 28 works is, if you think about ... the rate of cellular renewal within your body. If you ... that rate of cellular renewal. What RENU 28 does is ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2RENU 28 Skin Care Now Available in Australia and New Zealand 2
... DIEGO, Sept. 2 Halozyme Therapeutics,Inc. (Nasdaq: ... and,commercializing products targeting the extracellular matrix, today,announced ... President,Research, Michael J. LaBarre, PhD, Vice President, ... Legal., "Halozyme is committed to attracting, ...
... licenses ... STAMFORD, Conn., Sept. 2 Purdue Pharma L.P. ... to end the OxyContin(R) (oxycodone HCl controlled-release) Tablets,patent infringement ... the Southern District of New York., According to ...
... Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that ... the Company is initiating a U.S.,Phase 2 ... in,combination with paclitaxel and carboplatin in patients ... or EGFR-activated tumours. The Principal,Investigator is Dr. ...
Cached Biology Technology:Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 2Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 3Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 4Purdue Pharma L.P. Announces Resolution of OxyContin(R) Patent Lawsuit with Mallinckrodt Inc. 2Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours 2Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours 3Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours 4
... Kilo-Sequencing is designed to aid sequence analysis ... multiple cloning sites (MCS) of M13 phage ... vectors (pUC18/19). The kit is used to ... DNA, thereby progressively moving the primer binding ...
Applications: Immunohistochemistry, ISH, FISH, CISH....
Attachments: Clip bar for tubes 10 to 19 mm in diameter Overall Dimension Height IC: 6 (15.2) Overall Dimension Length IC: 18.5 (46.9) Overall Dimension Width IC: 4 (10.2)...
Request Info...
Biology Products: