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New type of gene that regulates tumor suppressor PTEN identified
Date:2/24/2013

g proteins. Using model systems, the team has shown that the new pseudogene can control the expression of PTEN and make tumours more responsive to conventional chemotherapy.

"This means that we might one day be able to re-programme cancer cells to proliferate less, become more normal, and that resistance to chemotherapy can hopefully be avoided," says Per Johnsson. "We also believe that our findings can be very important for the future development of cancer drugs. What we're seeing here is just the tip of the iceberg. The human genome conceals no less than 15,000 or so pseudogenes, and it's not unreasonable to think that many of them are relevant to diseases such as cancer."


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