Navigation Links
New type of gene that regulates tumor suppressor PTEN identified
Date:2/24/2013

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs.

The development of tumours coincides with the activation of several cancer genes as well as the inactivation of other tumour-suppressing genes owing to damage to the DNA and to the fact that the cancer cells manage to switch off the transcription of tumour-suppressor genes. To identify what might be regulating this silencing, the researchers studied PTEN, one of the most commonly inactivated tumour-suppressor genes. It has long been believed that the switching-off process is irreversible, but the team has now shown that silenced PTEN genes in tumour cells can be 'rescued' and re-activated by a 'pseudogene', a type of gene that, unlike normal genes, does not encode an entire protein.

"We identified a new non-protein encoding pseudogene, which determines whether the expression of PTEN is to be switched on or off," says research team member Per Johnsson, doctoral student at Karolinska Institutet's Department of Oncology-Pathology. "What makes this case spectacular is that the gene only produces RNA, the protein's template. It is this RNA that, through a sequence of mechanisms, regulates PTEN. Pseudogenes have been known about for many years, but it was thought that they were only junk material."

No less than 98 per cent of human DNA consists of non-protein encoding genes (i.e. pseudogenes), and by studying these formerly neglected genes the researchers have begun to understand that they are very important and can have an effect without encodin
'/>"/>

Contact: The Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies liver gene that regulates cholesterol and fat blood levels
2. Testosterone regulates solo song of tropical birds
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Gut microbiota regulates bile acid metabolism
5. Law that regulates shark fishery is too liberal: UBC study
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Omega-3s inhibit breast cancer tumor growth, study finds
8. Researchers in Manchester find genetic key to preventing spine tumors
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Tumor blood vessels prevent the spread of cancer cells
11. Compound stimulates tumor-fighting protein in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/28/2014)... from North America, Europe and China have published a ... of Sciences that reveals important details about key ... planet., From strange and exotic algae, mosses, ferns, trees ... grains and vegetables we eat and the ornamental plants ... over a billion years of history., "Our study generated ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
(Date:10/27/2014)... This news release is available in German . ... rapidly propagate information in their interior via electrical signals, ... known as the synapses. Chemical messenger substances, the neurotransmitters, ... synapse becomes active, some of these vesicles fuse with ... that valuable time is not lost, synapses always have ...
Breaking Biology News(10 mins):New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3Synapses always on the starting blocks 2Synapses always on the starting blocks 3
... brain imaging techniques, researchers at Georgetown University Medical Center have ... to learn novel tasks, an advance they say may help ... offer strategies to retrain people with perceptual deficits due to ... , the research team provides the first human evidence for ...
... An artificial nose could be a real benefit at ... explosives or drugs, for instance. Researchers at the Max ... Institute of Biochemistry recently revealed a technique for integrating ... important functions in the cell, one of which is ...
... from the University of Pittsburgh Cancer Institute's Center for ... contain substances that mimic the actions of estrogen, the ... and can concentrate chemicals from their habitat within their ... making their way into the region's waterways. , ...
Cached Biology News:Using brain scans, researchers find evidence for a two-stage model of human perceptual learning 2Using brain scans, researchers find evidence for a two-stage model of human perceptual learning 3Instruction manual for creating a molecular nose 2What's in the water? Estrogenic activity documented in fish caught in Pittsburgh's rivers 2
(Date:10/30/2014)... Ras Al Khaimah, UAE (PRWEB) October 30, 2014 ... the appointment of Dr. James A. Manganello, Chairman of the ... (NSCEC) of The Bahamas. The appointment was made by ... The Bahamas on September 24th, 2014. , More ... Cell Therapy and Research Bill , Prime Minister Perry Christie ...
(Date:10/30/2014)... in the development of quantum technologies has been proposed ... published today (28 October) in Nature Communications , ... a new type of flexibly designed microscopic trap for ... and specialised superfast computers, often depend on harnessing the ... these tiny particles are hugely problematic because of the ...
(Date:10/27/2014)... 27, 2014 The Italian ... exhibit and sell its artificial "lower limb", after ... patent.      (Photo: http://photos.prnewswire.com/prnh/20141027/713097 ... fighting, the definitive judgement has arrived: Roadrunnerfoot, the ... and accessible hi-tech prostheses with composite materials, has ...
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
Breaking Biology Technology:Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2SoundConnect Unveils Q4 Partner Incentives 2
... will be celebrated with a special ceremony that features H.R.H. ... Kavli laureates. Acclaimed scientists in the fields of astrophysics, nanoscience ... The award ceremony, lectures and symposia are open to media. ... September 9, in Oslo Concert Hall prior to the ceremony, ...
... LAS VEGAS, Aug. 26 Desert Radiologists, Nevada,s,largest ... that five,new physicians have joined the team of ... years., (Logo: http://www.newscom.com/cgi-bin/prnh/20050322/DRLOGO ), ... 1995 when he graduated,from the University of Pennsylvania ...
... Cell,Culture, Life Science Research and Diagnostics Industry Adds Seasoned Sales, ... ... Safety and Time to Market, FORT COLLINS, Colo., ... of animal free,products that enhance productivity, safety and time to ...
Cached Biology Technology:Inaugural Kavli Prize ceremony and symposia: Sept. 8-11 (Oslo, Norway) 2Inaugural Kavli Prize ceremony and symposia: Sept. 8-11 (Oslo, Norway) 3Desert Radiologists Welcomes Five New Physicians to the Practice 2Desert Radiologists Welcomes Five New Physicians to the Practice 3InVitria Expands Sales Team 2InVitria Expands Sales Team 3
ANTI-HUMAN CYTOKINES, GROWTH FACTORS (polyclonal rabbit (or goat) antibodies) Human TARC - Biotin...
Mouse monoclonal [7C6] to Bcr-abl ( Abpromise for all tested applications). SwissProtID: P11274...
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Chicken polyclonal to Thioredoxin domain containing 9 ( Abpromise for all tested applications). Antigen: Full length protein (Human) Entrez Gene ID: 10190 Swiss Protein ID: O14530...
Biology Products: