Navigation Links
New type of gene that regulates tumor suppressor PTEN identified
Date:2/24/2013

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs.

The development of tumours coincides with the activation of several cancer genes as well as the inactivation of other tumour-suppressing genes owing to damage to the DNA and to the fact that the cancer cells manage to switch off the transcription of tumour-suppressor genes. To identify what might be regulating this silencing, the researchers studied PTEN, one of the most commonly inactivated tumour-suppressor genes. It has long been believed that the switching-off process is irreversible, but the team has now shown that silenced PTEN genes in tumour cells can be 'rescued' and re-activated by a 'pseudogene', a type of gene that, unlike normal genes, does not encode an entire protein.

"We identified a new non-protein encoding pseudogene, which determines whether the expression of PTEN is to be switched on or off," says research team member Per Johnsson, doctoral student at Karolinska Institutet's Department of Oncology-Pathology. "What makes this case spectacular is that the gene only produces RNA, the protein's template. It is this RNA that, through a sequence of mechanisms, regulates PTEN. Pseudogenes have been known about for many years, but it was thought that they were only junk material."

No less than 98 per cent of human DNA consists of non-protein encoding genes (i.e. pseudogenes), and by studying these formerly neglected genes the researchers have begun to understand that they are very important and can have an effect without encodin
'/>"/>

Contact: The Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies liver gene that regulates cholesterol and fat blood levels
2. Testosterone regulates solo song of tropical birds
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Gut microbiota regulates bile acid metabolism
5. Law that regulates shark fishery is too liberal: UBC study
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Omega-3s inhibit breast cancer tumor growth, study finds
8. Researchers in Manchester find genetic key to preventing spine tumors
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Tumor blood vessels prevent the spread of cancer cells
11. Compound stimulates tumor-fighting protein in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 The biosensors market is proving highly ... into newer sectors, and development of devices resulting in ... has seen the entry of multiple participants each year ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... the Global Biosensors Market ( http://www.frost.com/nee9 ), finds ...
(Date:7/31/2015)... China , 31 de julio de 2015 /PRNewswire/ ... Genómica (ICG-10,  www.icg-10.org ) del 22 al 25 de ... . La conferencia celebra su décimo aniversario ... ha convertido en una de las reuniones anuales más ... y es una de las conferencias científicas más dinámicas, ...
(Date:7/31/2015)... OXFORD, Conn. , Jul. 31, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies ... technology by introducing a common, uniform way to manage ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... Scientists in the UK and Denmark have shown ... exercised their legs showed an appreciable muscle mass increase. ... School, UK) says: "This raises the question: Can age-related ... by the therapeutic application of mechano growth factor (MGF)?". ...
... of Physics and Astronomy at the University of Leicester ... them to the discovery of fluorescent silicon nanoparticles and ... the body,s cells. Dr Klaus von Haeften explained: ... the independent control of the nanoparticles, size and their ...
... team of Harvard scientists has taken an important first step ... HIV battle Mycobacterium tuberculosis (TB) infection. In their ... Journal of Leukocyte Biology ( http://www.jleukbio.org ) they ... used by the lungs to fight TB infection. This information ...
Cached Biology News:University of Leicester researchers discover new fluorescent silicon nanoparticles 2Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection 2
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
(Date:8/27/2015)... 2015 HUYA Bioscience International (HUYA) today announced the ... Society of HTLV-1, held this week at the University ... the Society is to promote research on HTLV-1 and ... technology and research related to these fields to advance ... is proud to support this prestigious conference," said ...
(Date:8/27/2015)... Switzerland (PRWEB) , ... August 27, 2015 , ... ... on customers’ weighing needs and expertly narrows down the product choices to a ... selection criteria pares down the list to models that fit best with the ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, ... second US laboratory is to open in Manhattan, Kansas in early October, 2015. ... long-term growth of research and development through collaboration with researchers from Kansas State ...
Breaking Biology Technology:Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4METTLER TOLEDO Updates Online Scale Selection Tool 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3
... are in for DEMOfall 2006 and - to paraphrase Sally Field ... compliments (thank you very much), there was a keen observation: that ... an apt enough description of some of the technologies on the ... as well. A feature, one might argue, does not a company ...
... for Advanced Technology and Innovation , a non-profit intellectual ... into unused and underused technologies, is taking its technology ... at facilitating the launch of new products and companies ... and elsewhere while building connections for further business creation ...
... to building an effective board of directors, it's a different world ... wake of accounting scandals that rocked corporate America and led to ... time and commitment than ever, and there is more liability and ... company - public or private - ensure that its board not ...
Cached Biology Technology:Sometimes, features can make a company 2Sometimes, features can make a company 3CATI takes tech transfer model national 2CATI takes tech transfer model national 3Directors more assertive in corporate governance 2Directors more assertive in corporate governance 3Directors more assertive in corporate governance 4
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Inquire...
1M stock solution (238mg/ml)...
...
Biology Products: