Navigation Links
New type of gene that regulates tumor suppressor PTEN identified
Date:2/24/2013

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs.

The development of tumours coincides with the activation of several cancer genes as well as the inactivation of other tumour-suppressing genes owing to damage to the DNA and to the fact that the cancer cells manage to switch off the transcription of tumour-suppressor genes. To identify what might be regulating this silencing, the researchers studied PTEN, one of the most commonly inactivated tumour-suppressor genes. It has long been believed that the switching-off process is irreversible, but the team has now shown that silenced PTEN genes in tumour cells can be 'rescued' and re-activated by a 'pseudogene', a type of gene that, unlike normal genes, does not encode an entire protein.

"We identified a new non-protein encoding pseudogene, which determines whether the expression of PTEN is to be switched on or off," says research team member Per Johnsson, doctoral student at Karolinska Institutet's Department of Oncology-Pathology. "What makes this case spectacular is that the gene only produces RNA, the protein's template. It is this RNA that, through a sequence of mechanisms, regulates PTEN. Pseudogenes have been known about for many years, but it was thought that they were only junk material."

No less than 98 per cent of human DNA consists of non-protein encoding genes (i.e. pseudogenes), and by studying these formerly neglected genes the researchers have begun to understand that they are very important and can have an effect without encoding proteins. Using model systems, the team has shown that the new pseudogene can control the expression of PTEN and make tumours more responsive to conventional chemotherapy.

"This means that we might one day be able to re-programme cancer cells to proliferate less, become more normal, and that resistance to chemotherapy can hopefully be avoided," says Per Johnsson. "We also believe that our findings can be very important for the future development of cancer drugs. What we're seeing here is just the tip of the iceberg. The human genome conceals no less than 15,000 or so pseudogenes, and it's not unreasonable to think that many of them are relevant to diseases such as cancer."


'/>"/>

Contact: The Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. Study identifies liver gene that regulates cholesterol and fat blood levels
2. Testosterone regulates solo song of tropical birds
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Gut microbiota regulates bile acid metabolism
5. Law that regulates shark fishery is too liberal: UBC study
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Omega-3s inhibit breast cancer tumor growth, study finds
8. Researchers in Manchester find genetic key to preventing spine tumors
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Tumor blood vessels prevent the spread of cancer cells
11. Compound stimulates tumor-fighting protein in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... WARSAW, Ind. , Feb. 7, 2017 ... global leader in musculoskeletal healthcare, will present at the ... Lotte New York Palace Hotel on Wednesday, February 15, ... A live webcast of the presentation can be accessed ... for replay following the conference via Zimmer Biomet,s Investor ...
(Date:2/3/2017)... 3, 2017 A new independent identity strategy ... LLP (IdSP) . Designed to fill a critical niche ... market, founding partners Mark Crego and ... just in identity expertise that span federal governments, the ... The Crego-Kephart combined expertise has a common theme born ...
(Date:2/1/2017)... 1, 2017 IDTechEx Research, a leading provider ... announces the availability of a new report, Sensors for Robotics: ... Continue Reading ... ... robots. Source: IDTechEx Report "Sensors for Robotics: Technologies, Markets and Forecasts ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  Seattle,s upscale Capitol Hill neighborhood, ... strange place for a head lice treatment salon to set ... a Tuscan restaurant and a French bistro on E Madison ... "We aren,t just any old lice clinic, we pride ourselves ... comfortable, and release some of the stigma associated with lice. ...
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, Inc. has received ... SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. The adjunctive seizure ... periods of rest. A lightweight, non-invasive monitor is placed on the belly of ...
(Date:2/23/2017)... ... February 23, 2017 , ... David ... Inventors Recognition Reception at Purdue Research Park of West Lafayette, Indiana. ... recognition of outstanding contributions to, and success with, commercializing discoveries from Purdue research. ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Greater Gift Initiative, Inc , (GGI) ... Compass Research . GGI's mission is to advance global health and highlight the greater ... in honor of each clinical trial volunteer. The vision of GGI is to serve ...
Breaking Biology Technology: