Navigation Links
New type of MRSA in hospitalized patients probably of animal origin
Date:6/2/2011

WASHINGTON, DC -- June 2, 2011 -- A distinctly new type of methicillin resistant Staphylococcus aureus (MRSA) that is not detected by traditional genetic screening methods has been discovered in patients in Irish hospitals according to research to be published in the journal Antimicrobial Agents and Chemotherapy. These findings provide significant insights into how new MRSA strains emerge and highlight the potential for the transmission of infectious agents from animals to humans.

MRSA is a significant cause of hospital- and community-acquired infection worldwide. MRSA strains are characterized by the presence of a mobile DNA cassette (known as SCCmec) encoding genes that confer resistance to beta-lactam antibiotics including methicillin and recombinase genes that allow the cassette to transfer into methicillin-susceptible S. aureus (MSSA).

Scientists at the University of Dublin, the Irish National MRSA Reference Laboratory and the University of Dresden and Alere Technologies in Germany identified the new MRSA strain using high throughput DNA microarray screening. Complete genome sequencing revealed that this strain is distinctly different to previously described MRSA. It carries a new type of SCCmec encoding highly divergent genes that are very different to any described previously in MRSA or in any other organism. Consequently the new strain is not detected as MRSA by routine conventional and real time DNA-based polymerase chain reaction (PCR) assays commonly used to screen patients for MRSA. The MRSA strain was found to belong to the genetic lineage clonal complex 130 (CC130), which has previously only been associated with MSSA from cows and other animals, but not humans, strongly suggesting that the new MRSA originated in animals.

During the publication process, the authors became aware that a consortium of researchers lead by the University of Cambridge and the Wellcome Trust Sanger Institute in the United Kingdom had identified bovine MRSA with an almost identical SCCmec element to that in the Irish CC130 human MRSA. These researchers also identified MRSA harboring the novel SCCmec element emerging in bovine and human populations in the United Kingdom and Denmark. This study will be published simultaneously in Lancet Infectious Diseases.

Commenting on the significance of the findings, Professor David Coleman from the University of Dublin said: "The results of our study and the independent United Kingdom study indicate that new types of MRSA that can colonize and infect humans are currently emerging from animal reservoirs in Ireland and Europe and it is difficult to correctly identify them as MRSA. This knowledge will enable us to rapidly adapt existing genetic MRSA detection tests, but has also provided invaluable insights into the evolution and origins of MRSA."


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
2. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
3. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
4. Text focuses on diagnosing infections in immunocompromised patients
5. UCSF Fresno leading-edge study lends hope to emphysema patients
6. How eating fruit and vegetables can improve cancer patients response to chemotherapy
7. New test promises quicker, more accurate evaluation for cystic fibrosis patients
8. Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
9. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
10. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
11. Stroke patients soon may have fun, high-tech tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... HOLLOWAY AMERICA, a stainless ... premier packaging event PACK EXPO International in Las Vegas from September 25 to ... , At this year’s PACK EXPO at the Last Vegas Convention Center, HOLLOWAY ...
(Date:9/21/2017)... ... , ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, will be ... at 12:10pm in the Probiotics Resource Center, Mandalay Bay Expo Hall. , “I ... probiotics have shown impressive data in areas outside the gut including heart health, Vitamin ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... bright neon green this month, the response was swift and efficient thanks to ... RRWQG ). RRWQG is made up of more than 50 stakeholders, including officials ...
(Date:9/20/2017)... CT (PRWEB) , ... September 20, 2017 , ... Diversity ... 2nd annual multi-city Fueling the Growth pitch competition to uncover the top technology-driven, women-led ... will be an integral part of each city’s entrepreneurial events going on that week ...
Breaking Biology Technology: