Navigation Links
New type of MRSA in hospitalized patients probably of animal origin
Date:6/2/2011

WASHINGTON, DC -- June 2, 2011 -- A distinctly new type of methicillin resistant Staphylococcus aureus (MRSA) that is not detected by traditional genetic screening methods has been discovered in patients in Irish hospitals according to research to be published in the journal Antimicrobial Agents and Chemotherapy. These findings provide significant insights into how new MRSA strains emerge and highlight the potential for the transmission of infectious agents from animals to humans.

MRSA is a significant cause of hospital- and community-acquired infection worldwide. MRSA strains are characterized by the presence of a mobile DNA cassette (known as SCCmec) encoding genes that confer resistance to beta-lactam antibiotics including methicillin and recombinase genes that allow the cassette to transfer into methicillin-susceptible S. aureus (MSSA).

Scientists at the University of Dublin, the Irish National MRSA Reference Laboratory and the University of Dresden and Alere Technologies in Germany identified the new MRSA strain using high throughput DNA microarray screening. Complete genome sequencing revealed that this strain is distinctly different to previously described MRSA. It carries a new type of SCCmec encoding highly divergent genes that are very different to any described previously in MRSA or in any other organism. Consequently the new strain is not detected as MRSA by routine conventional and real time DNA-based polymerase chain reaction (PCR) assays commonly used to screen patients for MRSA. The MRSA strain was found to belong to the genetic lineage clonal complex 130 (CC130), which has previously only been associated with MSSA from cows and other animals, but not humans, strongly suggesting that the new MRSA originated in animals.

During the publication process, the authors became aware that a consortium of researchers lead by the University of Cambridge and the Wellcome Trust Sanger Institute in the United Kingdom had identified bovine MRSA with an almost identical SCCmec element to that in the Irish CC130 human MRSA. These researchers also identified MRSA harboring the novel SCCmec element emerging in bovine and human populations in the United Kingdom and Denmark. This study will be published simultaneously in Lancet Infectious Diseases.

Commenting on the significance of the findings, Professor David Coleman from the University of Dublin said: "The results of our study and the independent United Kingdom study indicate that new types of MRSA that can colonize and infect humans are currently emerging from animal reservoirs in Ireland and Europe and it is difficult to correctly identify them as MRSA. This knowledge will enable us to rapidly adapt existing genetic MRSA detection tests, but has also provided invaluable insights into the evolution and origins of MRSA."


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
2. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
3. UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
4. Text focuses on diagnosing infections in immunocompromised patients
5. UCSF Fresno leading-edge study lends hope to emphysema patients
6. How eating fruit and vegetables can improve cancer patients response to chemotherapy
7. New test promises quicker, more accurate evaluation for cystic fibrosis patients
8. Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
9. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
10. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
11. Stroke patients soon may have fun, high-tech tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:5/19/2017)... ... , ... In response to the strong base of evidence supporting the use ... release of their Gait Trainer 3 with an Integrated Music Therapy option. This is ... in rehabilitating individuals with cerebral palsy, traumatic brain injury, stroke and Parkinson’s disease. ...
(Date:5/18/2017)... ... 18, 2017 , ... Dr. Ralph Mobbs of the Neuro ... Wales Private Hospital. The procedure was performed on a 46-year-old male patient suffering ... prior to undergoing surgery. , The AxioMed viscoelastic disc is a next-generation disc ...
(Date:5/18/2017)... ... ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, ... has doubled in size over the past six months with the acquisition of businesses ... joins CSM as Chief Financial Officer. Roger has over 25 years of experience ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... and further enhances its scientific power by providing investigators access to a ... agreed to join the scientific advisory board. “We are committed to offering ...
Breaking Biology Technology: