Navigation Links
New treatment for irritability in autism
Date:5/31/2012

Philadelphia, PA, May 31, 2012 Autism is a developmental disorder that affects social and communication skills. Irritability is a symptom of autism that can complicate adjustment at home and other settings, and can manifest itself in aggression, tantrums, and self-injurious behavior. These disruptive behaviors are frequently observed in children with autism, which may considerably affect their ability to function at home or in school.

N-acetylcysteine (NAC) is approved by the US Food and Drug Administration for the treatment of acetaminophen (Tylenol) overdoses, but it may have other applications related to its effects in the brain. NAC helps maintain and restore glutathione, which play a key role in the antioxidant defense system. Additionally, cysteine as supplied by NAC treatment, stimulates a protein, the cystine-glutamate antiporter, resulting in the decrease of glutamatergic neurotransmission. NAC has two resulting effects: 1) it may protect brain cells by raising the level of a protective antioxidant metabolite called glutathione, and 2) it may reduce the excitability of the glutamate system by stimulating inhibitory receptors.

These drug actions are important because, although the causes of autism are unknown, it is clear that there are many influencing factors and scientists are pursuing multiple hypotheses. Two in particular relate to NAC: one theory is that autism may be caused by an imbalance between oxidants and antioxidants in the body; the other is that the glutamate system may be dysfunctional in individuals with autism.

These hypotheses led researchers at Stanford University and the Cleveland Clinic to conduct a pilot trial of NAC in children with autistic disorder. Children were randomized to receive either NAC or placebo daily for 12 weeks and their symptoms were evaluated four times during that period.

They found that irritability was significantly decreased in the children who received NAC. In addition
'/>"/>

Contact: Rhiannon Bugno
biol.psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. The effect of treatment with antibiotics and vaccination against Q fever in sheep
2. Purdue professor to speak before Congress about nanotechnology in brain treatment research
3. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
4. Discovery of mechanisms predicting response to new treatments in colon cancer
5. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
6. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
7. Scientists discover new type of cell with a key role in treatment-resistant asthma
8. From urban climate research to the treatment of incontinence
9. Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
10. Beehive extract shows potential as prostate cancer treatment
11. Geneticist develops tool to identify genes important in disease, tailoring individual treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... Greenbelt, Md., is home to hundreds of dedicated ... some of the most cutting-edge Earth science innovation ... cutting-edge innovation has earned a Goddard scientist the ... Anthropology and Geography awards the Vega Medal every ... excellence in the fields of physical geography, exploration ...
(Date:4/15/2014)... mother-child pairs, researchers from the Bloomberg School of ... serotonin reuptake inhibitors (SSRIs), a frequently prescribed treatment ... with autism spectrum disorder (ASD) and developmental delays ... online edition of Pediatrics , analyzed data ... and population-based controls, where a uniform protocol was ...
(Date:4/15/2014)... COLUMBIA, Mo. University of Missouri researchers have previously ... less motivated to exercise exists. In a new study, ... Veterinary Medicine, has found a potential link between the ... the speed at which mental maturation occurs. , For ... of either extreme activity or extreme laziness. Booth then ...
Breaking Biology News(10 mins):Goddard scientist receives Vega Medal from King of Sweden 2Study: SSRI use during pregnancy associated with autism and developmental delays in boys 2Genetic pre-disposition toward exercise and mental development may be linked 2
... Guam has been an important military, communication, aviation, and ... of vegetables from Korea and the Philippines has resulted ... Dr. Reddy and his team will develop, demonstrate and ... eggplant farming that will enable growers to transition away ...
... of Deutsches rzteblatt International (Dtsch Arztebl Int ... coauthors present the PRISCUS List: a list of medications ... given to elderly patients. The authors present the ... the setting of a joint project entitled PRISCUS (Latin ...
... ago, Earth differed greatly from our modern environment, specifically ... atmosphere and the nature of the life forms inhabiting ... percent oxygen, the ancient atmosphere contained almost no oxygen. ... life we are familiar with animals, including humans ...
Cached Biology News:Ancient microbes responsible for breathing life into ocean 'deserts' 2Ancient microbes responsible for breathing life into ocean 'deserts' 3Ancient microbes responsible for breathing life into ocean 'deserts' 4
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... ... ... ... ...
... with a brain-computer interface device has allowed scientists to ... Characteristic activity patterns known as beta and delta ... brain since the early 20th century, and have been ... directly from a human subject,s motor cortex allowed University ...
... ... Board supported – has already yielded new discoveries. , ... (PRWEB) February 24, 2010 -- Completing the soybean genome sequence map ... already yielded new discoveries, among them:, , ,   ...
Cached Biology Technology:AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 2AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 3AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 4AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 5AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 6AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 7AFFiRiS AG: Vaccination Against Hypertension is Development Project No. 4 and has Already Been Awarded an FFG Grant of up to EUR 1.2 Million 8Brain implant reveals the neural patterns of attention 2Brain implant reveals the neural patterns of attention 3Brain implant reveals the neural patterns of attention 4Soybean Genome Mapping, New Soy Products Aid in Sustainable Agriculture 2Soybean Genome Mapping, New Soy Products Aid in Sustainable Agriculture 3
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Mouse Axl MAb (Clone 175128)...
Mouse GDF-8 Propeptide Affinity Purified Polyclonal Ab...
... S.J. Allen (1995) This book ... authorities on current issues relating to the ... major advances have been made recently which ... Topics include molecular neuropathology through clinical and ...
Biology Products: