Navigation Links
New treatment boosts bone healing and regrowth
Date:1/10/2008

BIRMINGHAM, Ala. A drug originally used to treat iron poisoning can significantly boost the bodys own ability to heal and re-grow injured bones, according to researchers at the University of Alabama at Birmingham (UAB).

The researchers injected the drug deferoxamine (DF), which is designed to reduce iron overload, into injured mouse bones. They found DF triggered the growth of new blood vessels, which in turn kicked off bone re-growth and healing.

In the study, bone density surrounding the injury more than doubled to 2.6 cubic millimeters in treated bones compared to 1.2 cubic millimeters in untreated bones, the researchers said. The new blood vessel growth and bone healing was achieved through a cell pathway that helps the body respond to low oxygen levels, a common problem when blood supply is affected by bone fracture and disease.

Findings on this cell pathway have broad implications for improving treatment of bone fractures, bone disease and other musculoskeletal disorders, said Shawn Gilbert, M.D., an assistant professor of orthopedic surgery in the UAB School of

Medicine, and Chao Wan, M.D. Ph.D., an instructor in the UAB Department of Pathology, both co-authors on the study.

With DF activating this pathway, weve proven a significant point it is possible to explore new, safe and more affordable ways kick-start bone repair, Gilbert said.

Current treatments use complex proteins, which are expensive to make and cost thousands of dollars per dose. The type of agent used in this study is a simple, small molecule drug that costs hundreds, not thousands, Gilbert said.

The UAB findings are published in the online version of the journal Proceedings of the National Academy of Sciences and will soon appear in a print edition.

The results from this study are a milestone for future studies looking at other compounds and agents to improve new-blood-vessel growth in skeletal and other tissues that need adequate blood supply to regenerate, Wan said.

The UAB tests were performed in conjunction with a bone lengthening procedure commonly used in children and adults, and has proven to aid bone healing. The study mice were anesthetized for surgery, and one leg bone was cut clean through and a pulling device attached temporarily to stretch the bone gap for the next 10 days.

During the stretching, the bone gap was injected with five DF doses. Two weeks after the last DF dose, X-rays of the mice legs were taken to measure bone regeneration.

DF is a drug that binds to excess iron in the body and helps with excretion through the bowels and bladder, a process sometimes called iron chelation. DF is used to treat a variety of medical conditions, including iron overload, transfusion-related blood poisoning and in combination with dialysis.

In the findings on post-treatment increased bone density, the UAB researchers found significant increases in the number of new blood vessels, and excellent connectivity between those vessels. The new blood vessels are required regenerate bone of equal or better strength than the original bones.

Gilbert said it follows that this cell pathway is a prime target for future human studies using DF and other drugs to strengthen the bodys bone-healing potential, especially since poor blood supply is common in fractures and bone disease.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Nicotinic receptors may be important targets for treatment of multiple addictions
2. A new radiation therapy treatment developed for head and neck cancer patients
3. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
4. Presence of gene mutation helps guide thyroid cancer treatment
5. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
6. New genetic research into nicotine addiction shows promise for personalized treatment
7. Interleukin-8, key marker for colorectal cancer treatment
8. New class of drug offers hope to treatment-resistant AIDS patients
9. Paradigm shift in Alzheimerss research: new treatments
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... YORK , Feb. 1, 2016  Today, the ... Association (AHA) announced plans to develop a first of ... computing power of IBM Watson. In the first application ... AHA, IBM (NYSE: IBM ), and Welltok will ... and health assessments with cognitive analytics, delivered on Welltok,s ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
(Date:1/21/2016)... , January 21, 2016 ... a new market research report "Emotion Detection and Recognition ... Software Tools (Facial Expression, Voice Recognition and Others), ... Global forecast to 2020", published by MarketsandMarkets, the ... to reach USD 22.65 Billion by 2020, at ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... FREDERICK, Md. , Feb. 8, 2016 /PRNewswire/ ... advanced consumer medical devices, announced today that it ... for administrative proceedings from the Securities and Exchange ... Richard Staelin , Chairman of the Board ... Donnell Professor of Business Administration at The Fuqua ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... a wide range of loose, bulk foods at various stages of the production ... also used to inspect large bulk products post packaging such as sacks of ...
(Date:2/8/2016)... Inc. (NYSE MKT: NNVC) (the "Company"), a nanomedicine company developing anti-viral ... will present information about the company,s programs at the BIOCEO conference ... York City . --> --> ... EST. Registered attendees can request a one on one meeting through ... --> New York City . ...
(Date:2/8/2016)... Pharmacy, Inc. (NYSE: DPLO) announced today that its new website has gone live. On Thursday, Feb. ... Visit the new site: www.diplomat.is ... ... ... "The goal was to reimagine the website and create a ...
Breaking Biology Technology: