Navigation Links
New tools help neuroscientists analyze 'big data'
Date:7/27/2014

running speed.

For analyzing much larger data sets, tools such as Thunder are not just helpful, they are essential, the scientists say. This is true for the information collected by the new microscope that Ahrens and colleagues developed for monitoring whole-brain activity in response to visual stimuli.

Last year, Ahrens and Janelia group leader Phillip Keller used high-speed light-sheet imaging to engineer a microscope that captures neuronal activity cell by cell across nearly the entire brain of an immature zebrafish. That microscope produced stunning images of neurons in the zebrafish brain firing while the fish was inactive. But Ahrens wanted to use the technology to study the brain's activity in more complex situations. Now, the team has combined their original technology with a virtual-reality swim simulator that Ahrens previously developed to provide fish with visual feedback that simulates movement.

In a light sheet microscope, a sheet of laser light scans across a sample, illuminating a thin section at a time. To enable a fish in the microscope to see and respond to its virtual-reality environment, Ahrens' team needed to protect its eyes. So they programmed the laser to quickly shut off when its light sheet approaches the eye and restart once the area is cleared. Then they introduced a second laser that scans the sample from a different angle to ensure that the region of the brain behind the eyes is imaged. Together, the two lasers image the brain with nearly complete coverage without interfering with the animal's vision.

Combining these two technologies lets Ahrens monitor activity throughout the brain as a fish adjusts its behavior based on the sensory information it receives. The technique generates about a terabyte of data in an hour presenting a data analysis challenge that helped motivate the development of Thunder. When Freeman and Ahrens applied their new tools to the data, patterns quickly emerged. As examples,
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
3. Researchers announce GenomeSpace environment to connect genomic tools
4. Michael J. Fox Foundation grant to Dr. Samuel Young will provide Parkinsons drug development tools
5. New tools for evaluating quality of life for cats, dogs with heart disease
6. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
7. DataONE answers the call for new tools to study the Earth in this era of Big Data science
8. Forensic tools for catching poachers
9. New uses for old tools could boost biodiesel output
10. New inhibitors of elusive enzymes promise to be valuable scientific tools
11. UCSB scientists report new beginning in split-brain research, using new analytical tools
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... regarding Ebola is critical and pertinent for practicing physicians ... outbreak and epidemic. The Journal, Disaster Medicine and ... Ebola Virus and Public Health, to surround the public, ... critical societal moment. , On October 17, the ... . The primer was prepared by Dr. Eric Toner, ...
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... length but their size belies the major role they play in ... the primary food source for many species of whales, seals, penguins ... temperature, especially in the areas where they grow as adults. This ... to the effects of further climate change., Using statistical models, a ...
... USA researchers will begin a programme of novel ... crops the ability to thrive without using costly, ... innovative projects include: searching the planet for a ... biology to create a new intracellular machine allowing ...
... Wis. By any measure, tuberculosis (TB) is a wildly successful ... corner of the world, with a new infection of a human ... new analysis of dozens of tuberculosis genomes gathered from around the ... is so prevalent and how it evolves to resist countermeasures. Writing ...
Cached Biology News:Warming Antarctic seas likely to impact on krill habitats 2UK & USA scientists collaborate to design crops of the future 2UK & USA scientists collaborate to design crops of the future 3UK & USA scientists collaborate to design crops of the future 4Tuberculosis genomes portray secrets of pathogen's success 2
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market report ... Americas with analysis and forecast of revenue. , ... Refrigerants Market report, to get an idea of ... glimpse of the segmentation in the Americas inorganic ... and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html , ...
(Date:10/22/2014)... October 22, 2014 Currently offering ... A & D Weighing, Rice Lake, and Ohaus, ... Balance . The Sartorius CPA Semi-Micro Balance is ... high-quality, precise, and user-friendly laboratory balance. , Sartorius ... equipment, their laboratory balances are well known for ...
(Date:10/22/2014)... VANCOUVER , Oct. 22, 2014 /PRNewswire/ - iCo ... ICOTF), today announced next steps for its Oral ... findings from its in vitro work ... therapy.  iCo now plans to complete pre clinical ... an initial Phase 1A clinical trial, utilizing approximately ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
... of Madison has been licensed to sell a ... agents, GenTel announced on Tuesday. , ,GenTel will market ... Kreatech Biotechnology BV of Amsterdam, under its ... are validated for use on GenTel's PATH protein microarray ...
... drive thru Illinois you now pay a premium for using cash ... device for your car. If you stop for gas at a ... plastic device on their key chain to pay for gas. These ... applications to reduce costs, improve efficiency, and potentially improve the buyers ...
... Wis. - Former Wisconsin Gov. and Secretary of ... board of directors at C.R. Bard , the ... at the company's August board meeting. , ,Bard, a ... sells specialty devices for vascular, urology, oncology and surgical ...
Cached Biology Technology:
... HISTAR detection systems provide linking and ... with species specific primary antibodies for ... Visualisation is accomplished using an ultra-sensitive ... polymer labelling technology. Secondary antibodies are ...
... Enzyme concentration - 5 units/µL ,• High ... yields ,• Leaves an 'A' overhang ,• ... which exhibits very high activity in primer ... ensure the quality of the enzyme, each ...
... from Thermus aquaticus expressed in E. coli; ... of 250 units enzyme/tube and Buffer I ... the same enzyme as AmpliTaq DNA Polymerase ... separation process to ensure that contaminating bacterial ...
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
Biology Products: