Navigation Links
New tool to speed cancer therapy approval available

PHILADELPHIA Although cancer remains a leading cause of death in America, it can take up to 12 years to bring a new anti-cancer agent before the FDA and the success rate for approval is only five to 10 percent. That means many research hours and dollars are wasted chasing avenues that will not bring fruit.

The National Cancer Institute's Translational Research Working Group (TRWG) developed a set of tools that it believes will improve that process. The tools, known as "Pathways to Clinical Goals" are published in the September 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

"The NCI supports a great deal of excellent translational research, but inefficiencies arising from a lack of communication and coordinated effort prevent many promising leads from reaching clinical trials and eventual approval," said Lynn Matrisian, Ph.D, a special assistant in the Office of the Director, NCI. Matrisian co-chaired the TRWG, which was formed in 2005 with the goal of accelerating the pace of translational cancer research. Publication of the Pathways is expected to be a major step forward in this process.

There are six Pathways that address the following categories: anti-cancer agents (drugs or biologics), biospecimen-based assessment methods, immune response modifiers, image-based assessment modalities, intervention devices, and lifestyle alterations.

Each pathway is a flowchart with a series of steps intended to clarify and streamline the translational research process. For example, in the anti-cancer agent pathway, researchers are encouraged at the outset to address the following three questions:

  • Is the empirical basis for attributing clinical potential (alone and/or in combination) convincing?
  • Does the envisioned clinical need justify expenditure of resources?
  • Is it feasible to identify/develop an agent against this target?

If the answer to any of these questions is "no," then research leaders are encouraged to direct their research toward more effective plans.

Matrisian and her colleagues hope that the TRWG pathways will be widely used and that they will make the early translational research process more efficient.

"The NCI funds many important research projects, and we hope these pathways will help in placing each research opportunity in the broader context of tangible cancer detection, diagnosis, prevention, and treatment strategies. We believe the NCI 's experience will be an important resource for other groups advancing translational research as well," said Matrisian.


Contact: Jeremy Moore
American Association for Cancer Research

Related biology news :

1. Primate sperm competition: speed matters
2. New technology identifies warped fingerprints at warp speed
3. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
4. Speed plays crucial role in breaking proteins H-bonds
5. NSF awards Williams funding for high-speed imaging faciltity
6. Software developed by Boston College lab delivers speed and accuracy to genome research
7. Licking your wounds: Scientists isolate compound in human saliva that speeds wound healing
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. Protein chatter linked to cancer activation
Post Your Comments:
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
(Date:10/10/2017)... SANTA CRUZ, Calif. , Oct. 10, 2017 /PRNewswire/ ... SBIR grant from the NIH to develop RealSeq®-SC (Single ... preparation kit for profiling small RNAs (including microRNAs) from ... Cell Analysis Program highlights the need to accelerate development ... "New techniques for ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: