Navigation Links
New tool to speed cancer therapy approval available
Date:9/14/2008

PHILADELPHIA Although cancer remains a leading cause of death in America, it can take up to 12 years to bring a new anti-cancer agent before the FDA and the success rate for approval is only five to 10 percent. That means many research hours and dollars are wasted chasing avenues that will not bring fruit.

The National Cancer Institute's Translational Research Working Group (TRWG) developed a set of tools that it believes will improve that process. The tools, known as "Pathways to Clinical Goals" are published in the September 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

"The NCI supports a great deal of excellent translational research, but inefficiencies arising from a lack of communication and coordinated effort prevent many promising leads from reaching clinical trials and eventual approval," said Lynn Matrisian, Ph.D, a special assistant in the Office of the Director, NCI. Matrisian co-chaired the TRWG, which was formed in 2005 with the goal of accelerating the pace of translational cancer research. Publication of the Pathways is expected to be a major step forward in this process.

There are six Pathways that address the following categories: anti-cancer agents (drugs or biologics), biospecimen-based assessment methods, immune response modifiers, image-based assessment modalities, intervention devices, and lifestyle alterations.

Each pathway is a flowchart with a series of steps intended to clarify and streamline the translational research process. For example, in the anti-cancer agent pathway, researchers are encouraged at the outset to address the following three questions:

  • Is the empirical basis for attributing clinical potential (alone and/or in combination) convincing?
  • Does the envisioned clinical need justify expenditure of resources?
  • Is it feasible to identify/develop an agent against this target?

If the answer to any of these questions is "no," then research leaders are encouraged to direct their research toward more effective plans.

Matrisian and her colleagues hope that the TRWG pathways will be widely used and that they will make the early translational research process more efficient.

"The NCI funds many important research projects, and we hope these pathways will help in placing each research opportunity in the broader context of tangible cancer detection, diagnosis, prevention, and treatment strategies. We believe the NCI 's experience will be an important resource for other groups advancing translational research as well," said Matrisian.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Primate sperm competition: speed matters
2. New technology identifies warped fingerprints at warp speed
3. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
4. Speed plays crucial role in breaking proteins H-bonds
5. NSF awards Williams funding for high-speed imaging faciltity
6. Software developed by Boston College lab delivers speed and accuracy to genome research
7. Licking your wounds: Scientists isolate compound in human saliva that speeds wound healing
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. Protein chatter linked to cancer activation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: