Navigation Links
New tool helps scientists 'see' molecular signals of eye disease before symptoms arise
Date:4/29/2010

Forget what you know about how diseases are diagnosednew research published in the May 2010 print issue of The FASEB Journal (http://www.fasebj.org) details a noninvasive ground-breaking tool that detects signs of disease at early molecular stages before symptoms can be seen using traditional methods. Even better, this tool promises to detect some eye diseases so early that they may be reversed before any permanent damage can occur. Its use may well extend to other areas of the body in the future, and this tool may also give physicians a more precise way of evaluating the effectiveness of therapies.

"Quantitative knowledge of the dynamic molecular changes in health and disease will not only advance our understanding, but also change the way medicine will be practiced in the future," said Ali Hafezi-Moghadam, M.D., Ph.D., co-author of the study from the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology at Harvard Medical School in Boston.

To make this discovery, Hafezi-Moghadam and colleagues combined fluorescent microspheres with molecules found on the surface of immune cells. These molecules are up-regulated early in inflammation. The scientists took this compound and combined it once more with custom-designed imaging probes. Then they used both single- and double-combined probes targeting endothelial markers in the eyes of test animals because of the eye's unique accessibility to light-based imaging. Results showed a strikingly superior sensitivity of the double-conjugated probes that allowed detection of molecules that may be expressed at very low levels, which occurs in many diseases. The imaging probes also detected activated immune cells, leading to unprecedented quantitative knowledge about immune response to disease.

"This tool is a total game-changer: it detects inflammatory eye disease at the molecular level before damage occurs," said Gerald Weissmann, M.D., Edi
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. Device helps patients survive, regain function til transplant
3. Presence of gene mutation helps guide thyroid cancer treatment
4. CABI helps phase out dangerous pesticide in EU
5. Diet support helps chronic kidney patients
6. Argonne helps China create cleaner Beijing for 2008 Olympics
7. A tiny pinch from a z-ring helps bacteria cells divide
8. Ultraviolet light helps to secure water supply
9. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
10. Handbook helps parents deal with childhood infections
11. NASA technology helps predict and prevent future pandemic outbreaks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... understand how the repeated climatic shifts over the ... of genetic diversity, a team of researchers led ... Ana Carnaval developed a new biodiversity metric called ... which the genetic variation within species is restricted ... professor of biology, and 14 other researchers from ...
(Date:8/29/2014)... - In a cell,s nucleus, chromosomal DNA is ... an amalgam biologists call chromatin. Until about two ... "sidekick," the mere packing material around which the ... have developed a greater appreciation for how DNA/histone ... from multiple research institutions studying the sequence of ...
(Date:8/28/2014)... identified a handful of bacterial culprits that may drive ... ulcerative colitis, using patients, own intestinal immune responses as ... in the journal Cell . , Trillions of ... a critical role in the development and progression of ... of bacterial species affect a person,s susceptibility to IBD ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Yale study identifies possible bacterial drivers of IBD 2
... a man-made wetland in Ohio for two years concluded that ... or better than would a natural marsh. , The wetland, ... phosphorus by nearly 60 percent and nitrates by 40 percent. ... in water pollution. , High levels of these nutrients can ...
... after it burst onto the scene, HIV/AIDS has claimed ... societies around the world, particularly in Africa and other ... after years of effort AIDS researchers succeeded in developing ... effective against AIDS. By blocking the activity of the ...
... Children's Fund (UNICEF) today announced that countries are on target ... the end of this year. Global measles deaths have plummeted ... 530 000 in 2003. , The largest reduction occurred in ... where estimated measles deaths decreased by 46%. , "Progress of ...
Cached Biology News:Man-made wetland's effectiveness similar to natural marsh 2Man-made wetland's effectiveness similar to natural marsh 3Supercomputers to focus brains on AIDS dilemma 2Supercomputers to focus brains on AIDS dilemma 3Supercomputers to focus brains on AIDS dilemma 4Measles Deaths Worldwide Drop By Nearly 40% Over Five Years 2
(Date:8/29/2014)... 2014 Pittcon is pleased to announce ... Koichiro Matsuda, Horiba Scientific, have organized a session on ... JASIS , Asia’s largest analytical and scientific instruments ... Messe, Japan. , The four speakers in this ... Single Molecules to Single Cells” will present their use ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/29/2014)... August 29, 2014 Due to a misstatement ... week, the Adult Stem Cell Technology Center, LLC ( ASCTC ... stem cell therapy research that might benefit ALS patients. ... for new stem cell technologies and therapeutic applications, FRC listed ... Bucket Challenge donors who wish not to support research ...
(Date:8/29/2014)... TX (PRWEB) August 29, 2014 ... ISO 13485:2003 certified, GAMP® 5 compliant imaging core ... an international Phase II clinical trial to assess ... , Throughout this trial, Intrinsic Imaging will provide ... limited to, protocol and charter development, site qualification, ...
Breaking Biology Technology:Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... Research Park MADISON OpGen, Inc. has added ... and Thomas Pyle. The company is looking to bring in ... level, according to Dan Broderick, managing director of Mason ... of experience with company operations and product positioning, Broderick said. ...
... released Q2 MoneyTree Survey figures show no reported ... June of this year. Both total venture capital ... survey, which was released by PricewaterhouseCoopers, Thomson Venture ... other states also showed $0 activity. , ,The ...
... -- PointOne Systems , a company specializing ... chosen Frank Langely as its president and chief ... recently served as president and CEO of ... The company develops molecular biology and serologic products ...
Cached Biology Technology:OpGen adds Thomas Pyle and James Ogle to board of directors 2MoneyTree Survey reports no venture investment activity in Wisconin in Q2 2MoneyTree Survey reports no venture investment activity in Wisconin in Q2 3MoneyTree Survey reports no venture investment activity in Wisconin in Q2 4MoneyTree Survey reports no venture investment activity in Wisconin in Q2 5MoneyTree Survey reports no venture investment activity in Wisconin in Q2 6
... CHEMICON's In Vitro Osteogenesis Assay Kit ... MC3T3-E1cells to a mature osteoblastic lineage, as ... this kit provides all the necessary reagents ... a standard plate reader. This product is ...
... of discovery races ever faster, you need a ... track. So our constant focus is on providing ... Thats why our Biomek 3000 Laboratory Automation Workstation ... as it is flexible. By integrating all aspects ...
... Cycler is the ideal instrument for budget-conscious labs ... PCR applications. Get Applied Biosystems proven ... Save lab space without sacrificing results. ... PCR Technology You Can Afford The ...
... micro 10 represents a major advance in ... the benefits of large robotic liquid handlers ... dispenser. Dispensing accurate volumes ranging from 10mL ... has unique advantages not yet found in ...
Biology Products: