Navigation Links
New tool helps scientists 'see' molecular signals of eye disease before symptoms arise

Forget what you know about how diseases are diagnosednew research published in the May 2010 print issue of The FASEB Journal ( details a noninvasive ground-breaking tool that detects signs of disease at early molecular stages before symptoms can be seen using traditional methods. Even better, this tool promises to detect some eye diseases so early that they may be reversed before any permanent damage can occur. Its use may well extend to other areas of the body in the future, and this tool may also give physicians a more precise way of evaluating the effectiveness of therapies.

"Quantitative knowledge of the dynamic molecular changes in health and disease will not only advance our understanding, but also change the way medicine will be practiced in the future," said Ali Hafezi-Moghadam, M.D., Ph.D., co-author of the study from the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology at Harvard Medical School in Boston.

To make this discovery, Hafezi-Moghadam and colleagues combined fluorescent microspheres with molecules found on the surface of immune cells. These molecules are up-regulated early in inflammation. The scientists took this compound and combined it once more with custom-designed imaging probes. Then they used both single- and double-combined probes targeting endothelial markers in the eyes of test animals because of the eye's unique accessibility to light-based imaging. Results showed a strikingly superior sensitivity of the double-conjugated probes that allowed detection of molecules that may be expressed at very low levels, which occurs in many diseases. The imaging probes also detected activated immune cells, leading to unprecedented quantitative knowledge about immune response to disease.

"This tool is a total game-changer: it detects inflammatory eye disease at the molecular level before damage occurs," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "Once you have symptoms, it may be too late. By then, doctors are often limited to damage control. Now in the eye, and later in other areas of the body, early detection of molecular changes by fluorescent microspheres will save lives. It should certainly change people's expectations of when treatment is indicated."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. Device helps patients survive, regain function til transplant
3. Presence of gene mutation helps guide thyroid cancer treatment
4. CABI helps phase out dangerous pesticide in EU
5. Diet support helps chronic kidney patients
6. Argonne helps China create cleaner Beijing for 2008 Olympics
7. A tiny pinch from a z-ring helps bacteria cells divide
8. Ultraviolet light helps to secure water supply
9. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
10. Handbook helps parents deal with childhood infections
11. NASA technology helps predict and prevent future pandemic outbreaks
Post Your Comments:
(Date:10/29/2015)... , Oct. 29, 2015  Connected health pioneer, ... driving the explosion of technology-enabled health and wellness, and ... new book, The Internet of Healthy Things ... sensors or smartphones even existed, Dr. Kvedar, vice president, ... of health care delivery, moving care from the hospital ...
(Date:10/27/2015)... , Oct. 27, 2015 In the ... issues of concern for various industry verticals such as ... due to the growing demand for secure & simplified ... various ,sectors, such as hacking of bank accounts, misuse ... electronic equipment such as PC,s, laptops, and smartphones are ...
(Date:10/26/2015)... PUNE, India , October 26, ... --> --> ... Forecasts 2015 to 2021 as well ... Analysis 2015-2019 research reports to its ... . ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... In ... paramount. Insertion points for in-line sensors can represent a weak spot where leaking ... 781/784 series of retractable sensor housings , which are designed to tolerate extreme ...
(Date:11/24/2015)... HemoShear Therapeutics, LLC, a privately held ... disorders, announced today the appointment of H. ... (BOD). Mr. Watkins is the former president and ... and also served as the chairman of the ... Chairman and CEO of HemoShear Therapeutics. "The combination ...
(Date:11/23/2015)... Women with a certain type of lung nodule ... risk of lung cancer than men with similar nodules, according ... annual meeting of the Radiological Society of North ... --> Lung nodules are small masses of tissue ... based on their appearance on CT. Solid nodules are dense, ...
(Date:11/23/2015)... The royalty-free a greement ... develop daclatasvir for 112 low- and m ... --> --> The Medicines Patent Pool (MPP) ... signing an agreement with Bristol-Myers Squibb for daclatasvir, a novel ... of the HCV virus.  The royalty-free licence will enable generic ...
Breaking Biology Technology: