Navigation Links
New tool could unpick complex cancer causes and help sociologists mine Facebook
Date:12/15/2008

Researchers at the University of Warwick's Department of Statistics and Centre for Complexity Science have devised a new research tool that could help unpick the complex cell interactions that lead to cancer and also allow social scientists to mine social networking sites such as Facebook for useful insights.

An approach called "graphical models" can be used by researchers to gain an understanding of a range of systems with multiple interacting factors. These models use mathematical objects called graphs to describe and depict the probability of relationships between each of the components. When used to study molecular biology researchers may be interested in saying something about which molecules influence one another; in the social sciences researchers would use them to understand the relationships between various economic and demographic factors.

However gaining such information from a graphical model can be a very challenging exercise, because of the vast range of possible graphs needed for even a relatively small number of variables. For instance the relatively small network studied by the University of Warwick led team for this research paper had just 14 proteins which were implicated in the development of a form of cancer, but those 14 proteins had a vast number of combinations of possible mutual interactions.

Such tasks would be made much easier if the mathematical tools used to undertake the analysis could somehow embody all the current knowledge of what was likely, and or probable, in the networks they were analysing. Such a mathematical method could be viewed as mimicking how human researchers learn from data, in effect interpreting new information in light of what is already known.

The Warwick researchers led by Dr Sach Mukherjee of Warwick's Department of Statistics and Centre for Complexity Science have devised just such a method that embeds current knowledge in the mathematical analysis to cut through the vast complexity of this type of analysis using a mechanism called "Informative Priors".

The researchers took the 14 protein network and created a mathematical tool that was able to incorporate all of what the interactions, and limits on interactions, that were likely and/or probable in such a network of these particular proteins. This allowed a rapid and accurate analysis of the probabilities of interactions between each on the 14 proteins. The technique even able to cope with misconceptions in current understanding of particular networks as it the was designed to "overturn" any reject any data included in the "Informative Priors" that was consistently at odds with any observed new data.

Analysis with these network models was much better able to resolve complex interactions than simple, correlation-based methods. Moreover using informative priors, gave much more accurate results than analysis that incorporated no prior understanding of the network (so called "flat priors").

The researchers will now use their new technique to examine the network of proteins behind the development of breast cancer but they are also looking at how the tool could be used in social science to mine a vast amount of useful anonymised data from social networking sites such as Facebook to gain significant new understandings of large scale interactions and relationships in society at large.


'/>"/>

Contact: Dr. Sach Mukherjee
S.N.Mukherjee@warwick.ac.uk
44-024-761-50207
University of Warwick
Source:Eurekalert

Related biology news :

1. An essay proves that vegetation could recover in the ski resort of Sierra Nevada
2. New way of viewing cells could lead to easier routes for drug manufacture
3. New holographic method could be used for lab-on-a-chip technologies
4. 100-meter sprint world record could go as low as 9.48 seconds
5. Lightheadedness at the dentist could prove serious
6. Transporting broiler chickens could spread antibiotic-resistant organisms
7. Could genetic research awaken racist attitudes?
8. Protecting neurons could halt Alzheimers, Parkinsons diseases
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. Could vitamin D save us from radiation?
11. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing ...  3D medical LCD display is the latest premium product recently added to the range ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Cancer experts from Austria, Hungary, Switzerland, and ... new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just published ... , Biomarkers are components in the blood, tissue or body fluids that ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... While the majority ... as the Cary 5000 and the 6000i models are higher end machines that use ... height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
Breaking Biology Technology: