Navigation Links
New tool aids stem cell engineering for medical research
Date:8/28/2014

ROCHESTER, Minn. A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell.

"This free platform has a broad range of uses for all types of cell-based investigations and can potentially offer help to people working on all types of cancer," says Hu Li, Ph.D., investigator in the Mayo Clinic Center for Individualized Medicine and Department of Molecular Pharmacology & Experimental Therapeutics, and co-lead investigator in the two works. "CellNet will indicate how closely an engineered cell resembles the real counterpart and even suggests ways to adjust the engineering."

The network biology platform contains data on a wide range of cells and details on what is known about those cell types. Researchers say the platform can be applied to almost any study and allows users to refine the engineering process. In the long term, it should provide a reliable short cut to the early phases of drug development, individualized cancer therapies, and pharmacogenetics.

CellNet uses 21 cell types and tissues and data from 56 published human and mouse engineering studies as a basis for analyzing and predicting cell fate and corresponding engineering strategies. The platform also offers classification scores to determine differentiation and conversion of induced pluripotent stem cells. It reveals incomplete conversion of engineered microphages and hepatocytes. CellNet can be used for interrogation of cell fate following expression profiling, by classifying input by cell type, quantifying gene regulatory network status, and identifying aberrant regulators affecting the engineering process. All this is
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Melting glaciers, enough sand to bury London, and ancient ecosystem engineering
3. Innovative cell printing technologies hold promise for tissue engineering R&D
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. Medical device, health professionals attend first national conference on value-driven engineering
6. NSF report detailing growth in graduate enrollment in science & engineering in the past decade
7. Investigation of American Oriental Bioengineering, Inc. by Securities Lawyers at Goldfarb LLP Law Firm for Potential Shareholder Claim
8. Oligonucleotide Delivery: Biology, Engineering and Development Conference
9. GEN reports on growth of tissue engineering revenues
10. Engineering technology reveals eating habits of giant dinosaurs
11. Genetic Engineering & Biotechnology News unveils Biotech Boulevard
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... Calif. , May 11, 2015  Synaptics ... of human interface solutions, today announced the appointment ... President and Chief Financial Officer, reporting to ... replaces Synaptics, current Chief Financial Officer, Kathleen ... 2014. Mr. Ali brings extensive ...
(Date:5/10/2015)... Sweden , May 11, 2015 ... fingerprint sensors FPC1025 and FPC1155 from the distributor World Peace ... of FPC,s distributors in Asia . Deliveries ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of + 1 000 MSEK ...
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... 2014 A study conducted by Marie Kmita,s team ... McGill University, shows the importance of the chromatin architecture ... for proper embryonic development. This discovery, recently published in ... a significant impact on the diagnosis of genetic diseases. ...
... in the vicinity of a molecule can change spatial arrangement ... of researchers was able to change persistently positions of the ... a single copper atom to the molecule. A subatomic ... molecule can be switched by approaching a single copper atom ...
... (U of T) have found that the theory behind the ... by blood type--is not valid. The findings are published this ... on the data of 1,455 study participants, we found no ... author of the study, Dr. Ahmed El-Sohemy, Associate Professor and ...
Cached Biology News:Important discovery for the diagnosis of genetic diseases 22-proton bit controlled by a single copper atom 22-proton bit controlled by a single copper atom 3Popular blood type diet debunked 2
(Date:5/28/2015)... , May 27, 2015 ... the addition of Jain PharmaBiotech,s new report ... to their offering. An increasing ... biotechnology industries is anticipated. Nanotechnology will be ... - from formulations for optimal delivery to ...
(Date:5/28/2015)... 28, 2015 The Academy of Model Aeronautics ... Day on August 15, 2015. National Model Aviation Day was ... to introduce model flying to the general public. , The ... to participate in the celebration by hosting events in their ... National Model Aviation Day events. View our online event ...
(Date:5/28/2015)... BioNorth Texas (BioNorthTX), an independent, ... life sciences industry in northern region of Texas, ... The Foundry in Dallas on April 27, 2015. ... a broad spectrum of biotech professionals from the ... successes in partnering with key life sciences organizations ...
(Date:5/28/2015)...  GenVec, Inc. (Nasdaq: GNVC ) today announced ... , will present a company overview at the Jefferies ... Thursday, June 4, 2015. The live ... available at the following link:  http://wsw.com/webcast/jeff88/gnvc .  This ... access, visit www.genvec.com , click on "Investors and ...
Breaking Biology Technology:Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3GenVec To Present At The Jefferies Healthcare Conference 2
... at American Society of Pharmacognosy, EMERYVILLE, Calif., ... will present seminal information on a new drug ... 7th Annual Oxford International,Conference on the Science of ... April 12-16, 2008. Scott Baggett, Ph.D., a member ...
... April 14 Codexis, Inc. announced,today that it has ... U.S.,Securities and Exchange Commission ("SEC") relating to the proposed ... of the Codexis,registration statement on Form S-1 can be ... shares being offered and the price,range for the offering ...
... and reduced cost for ... pharmaceutical manufacturers, NEW YORK, ... agreement with Chiral Quest, Inc., a manufacturer and,developer of chiral ... chiral products to the pharmaceutical industry., Effective immediately, Sumitomo ...
Cached Biology Technology:Bionovo Identifies and Describes ER-beta Selective Compounds for the Treatment of Vaginal Dryness 2Bionovo Identifies and Describes ER-beta Selective Compounds for the Treatment of Vaginal Dryness 3Codexis, Inc. Files Registration Statement for Proposed Initial Public Offering 2Sumitomo Corporation of America Named Exclusive Distribution and Sales Agent for Chiral Quest 2
HLA II DG+DR+DP Monoclonal Antibody, Purified, Unconjugated, Clone: IQU9 This antibody is specific for the monomorphic determinant of the HLA Class II beta chains of the human MHC (28 kDa)....
100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Vascular Endothelial Growth Factor C Class: Antibody Product Group: Angiogensis...
Annexin V Binding Buffer, 10X Concentrate Buffer , 50 ml Consult technical datasheet for details....
Biology Products: