Navigation Links
New therapeutic target for prostate cancer identified
Date:7/17/2012

New Rochelle, NY, July 16, 2012A small, naturally occurring nucleic acid sequence, called a microRNA, known to regulate a number of different cancers, appears to alter the activity of the androgen receptor, which plays a critical role in prostate cancer. Directly targeting microRNA-125b to block androgen receptor activity represents a novel approach for treating castrate-resistant prostate cancer. This promising new strategy for improving the effectiveness of anti-androgenic and other hormonal therapies is described in an article in BioResearch Open Access, a new bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc.. The article is available free online at the BioResearch Open Access website.

Prostate cancer is the most common non-skin cancer affecting men and the second most common cause of cancer death among men. In the article "miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2," Xiaoping Yang, Lynne Bernis, Lih-Jen Su, Dexiang Gao, and Thomas Flaig, University of Colorado Denver (Aurora) and University of Minnesota (Duluth), looked for targets of microRNA-125b that might shed light on its role in regulating prostate cancer and found that it directly inhibits NCOR2, which acts to repress the androgen receptor. The authors point out that "the androgen receptor is a critical therapeutic target in prostate cancer" and that alterations in the receptor are essential for the development of castrate-resistant prostate cancer, in which the disease no longer responds to hormonal therapies.

"This research provides new insight into the mechanism of miR-125b regulation of castrate-resistance prostate cancer through the identification of a novel target for miR-125b," says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "The clinical implications of this study are that targeted regulation of this miRNA may lead to more effective anticancer therapies."


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Magical state of embryonic stem cells may help overcome hurdles to therapeutics
2. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
3. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
4. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
5. Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
6. UofL research holds promise of therapeutic approach for gum disease
7. AnaptysBio Adds Dr. David L. Lacey and Dr. Michael Gallatin to Therapeutic Advisory Board
8. Cancer Cell article shows first evidence for targeting of Pol I as new approach to cancer therapy
9. Developing world has less than 5 percent chance of meeting UN child hunger target, study estimates
10. Innate immune system protein provides a new target in war against bacterial infections
11. Antitoxin strategy may help target other pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New therapeutic target for prostate cancer identified
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... CO (PRWEB) , ... May 05, 2016 , ... ... diagnostics, is proud to support the National Stroke Association during National Stroke Awareness ... the association’s Facebook and Twitter pages throughout the month. CereScan will donate ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... than LaJollaCooks4u, San Diego’s premiere hands-on cooking experience. Offering everything from gourmet cooking ... an experience she won’t forget. , Guests that visit LaJollaCooks4u share an experience ...
(Date:5/4/2016)... ... May 04, 2016 , ... Proove Biosciences, Inc. , ... strategic partnership with McGill University . The partnership is designed to advance research ... order to help patients in pain. With the new agreement, researchers at Proove Biosciences ...
(Date:5/4/2016)... , May 4, 2016  Bayer today announced ... compound Stivarga ® (regorafenib) tablets for the ... has met its primary endpoint of a statistically ... RESORCE, evaluated the efficacy and safety of regorafenib ... after treatment with sorafenib. The safety and tolerability ...
Breaking Biology Technology: