Navigation Links
New test shows promise for detecting warning signs of joint replacement failure
Date:4/27/2011

A new test shows promise for detecting the early stages of a major cause of failure in joint replacement implants, so that patients can be treated and perhaps avoid additional surgery. More than 1.5 million total joint replacement operations are performed worldwide each year. While the success rate is 90 per cent, almost 10 per cent of implants fail and require additional surgery, report appears in the ACS journal Molecular Pharmaceutics.

Dong Wang and colleagues at University of Nebraska Medical Center and the Hospital for Special Surgery of New York explain that wear and tear in a joint replacement can create tiny bits of debris that cause local inflammation and lead to bone loss. When this happens, the implant can become loose and set the stage for failure. Treatment usually comes too late, they note, since it's difficult to detect the problem in its early stages. "When pain or clear radiographic evidence is reported, unfortunately, considerable bone loss has already occurred, which cannot be easily restored," the scientists note.

To provide an early diagnostic tool for implant failure, the researchers developed a polymer-based system for imaging the inflammation that is associated with the wear debris. Their tests of the imaging agent in mouse bone suggest that it can help them detect the early stages of bone loss that might cause a joint implant to become loose. They also found that they could tether a powerful anti-inflammatory drug to the polymeric system, offering a way to treat inflammation and bone loss in these early stages of wear. "Subsequent therapeutic interventions at this stage," they write, "would permit prolongation of the lifetime of the implant with improved patient outcomes."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Study shows how mosquitoes handle the heat of a hot blood meal
2. USC research shows critical role of placenta in brain development
3. Functional MRI shows how mindfulness meditation changes decision-making process
4. Polarized microscopy technique shows new details of how proteins are arranged
5. Periodontal stem cell transplantation shows promise
6. Soy increases effectiveness of radiation at killing lung cancer, Wayne State study shows
7. Chimpanzees contagious yawning evidence of empathy, not just sleepiness, study shows
8. Nanopolymer shows promise for helping reduce cancer side effects
9. Drought-exposed leaves adversely affect soil nutrients, study shows
10. Protein adaptation shows that life on early earth lived in a hot, acidic environment
11. Epidemiological tree study shows impacts of climate change on forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of that Rising Market Are you interested ... analysis forecasts revenues for checkpoint inhibitors. Visiongain,s report ... market, submarket, product and national level. Avoid ... discover what progress, opportunities and revenues those emerging ...
(Date:2/1/2016)... Feb. 1, 2016  Today, the first day of ... plans to develop a first of its kind workplace ... IBM Watson. In the first application of ... IBM ), and Welltok will create a new ... with cognitive analytics, delivered on Welltok,s health optimization platform. ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... Curoverse ... Azure. On Azure, Arvados provides capabilities for managing and processing genomic and health ... Azure from major institutions collecting and analyzing genomic data,” said Adam Berrey chief ...
(Date:2/10/2016)... ... ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused on the discovery and ... been selected to present at the Cavendish Global Health Impact Forum taking place February ... of the Forum is to help family offices and foundations develop and implement their ...
(Date:2/9/2016)... ... ... With a presidential election in November and the future of U.S. healthcare ... 500 top healthcare leaders for a night and day of debates and discussions about ... of the University of Pennsylvania’s Wharton School, will be held February 18 – 19, ...
(Date:2/9/2016)... ... 2016 , ... Date and time: March 1, 2016, 5:30 ... Biotechnology Center of Bucks County, 3805 Old Easton Road, Doylestown, PA 18902. , ... an open house for participants to learn about a new Master of Biomedical ...
Breaking Biology Technology: