Navigation Links
New test promises quicker, more accurate evaluation for cystic fibrosis patients
Date:10/23/2008

Researchers at National Jewish Health have identified a simple gene-based blood test that more accurately and quickly measures cystic fibrosis patients' response to therapy than current tests. The test, a measure of inflammatory gene expression, could improve patient care and help clear a backlog of promising medications now hung up in clinical trials. The researchers recently published the results of a small "proof-of-principal" trial in the online version of American Journal of Respiratory and Critical Care Medicine, and will also publish them in a future print issue.

"The currently accepted test, a measure of a patients' ability to exhale air, has several limitations that make it ineffective for some patients and not sensitive enough for clinical trials of many new medications," said Dr. Milene Saavedra, lead author of the study and Assistant Professor of Medicine at National Jewish Health. "By measuring the activity of genes associated with the immune/inflammatory response, we can get a more accurate picture of the biological processes occurring inside the lungs."

Cystic fibrosis is the most common lethal inherited disease in the western world, with about 30,000 patients in the US. Most patients die of respiratory failure generally in their 30s or 40s. Lung damage is caused primarily by chronic bacterial infections and the resulting severe airway inflammation. There is a critical need for new effective anti-microbial and anti-inflammatory medications to slow and/or prevent lung damage in young patients. Several promising therapies have gone through early stages of clinical testing but their progress is being hampered by the lack of a sensitive measure of therapeutic response to medications.

Currently, response to medication is measured by how much air a person can rapidly exhale: forced expiratory volume in one second or FEV1. FEV1 cannot be performed effectively for all patients, especially young and very sick patients. Generally patient
'/>"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Innovative civil engineering application promises cleaner waters
2. New CPR promises better results by compressing abdomen, not Chest
3. Prototype terahertz imager promises biochem advances
4. Telescope embedded in glasses lens promises to make driving easier for visually impaired
5. Genetic data promises new future for kiwi fruit
6. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
7. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
8. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
9. Safer, more accurate radiation therapy for expecting mothers
10. Swish-and-spit test accurate for cancer
11. New research suggests biofuel blending is often inaccurate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... other forms of dementia, but the research community is ... Washington bioengineers have a designed a peptide structure that ... proteins into a state that,s linked to widespread diseases ... and Lou Gehrig,s disease. The synthetic molecule blocks these ... an abnormally folded form by targeting a toxic intermediate ...
(Date:7/28/2014)... Research Hospital study found that 73 percent of adult ... of developing metabolic syndrome and related health problems by ... in the current issue of the journal Cancer ... survivors of childhood cancer in the study had metabolic ... high blood pressure, abdominal obesity, elevated triglyceride and other ...
(Date:7/28/2014)... 2014 Research and Markets has ... Latin America 2014-2018" report to their offering. ... measure and analyze biological data. These systems capture biological ... voice patterns, and hand measurements from the subject and ... The main purpose of a biometrics system is to ...
Breaking Biology News(10 mins):New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3Biometrics Market in Latin America 2014-2018 2
... The behavior of marine larvae is central to fully understanding ... organisms. For the first time, a numerical study conducted by ... skills into realistic 3D flow fields, creating a powerful tool ... their way back to the reef after being out on ...
... & Science division of Thomson Reuters, the world,s ... professionals, today announced the launch of its ... a new initiative aimed at enabling access to ... developed with third-party partners. Through the ...
... Africa could benefit from access to treatment for an endemic ... of infection. Researchers tested hundreds of children aged between ... fever also known as bilharzia or schistosomiasis is ... they are perceived to be at low risk of exposure ...
Cached Biology News:Fish larvae find the reef by orienting: The earlier the better 2Fish larvae find the reef by orienting: The earlier the better 3Thomson Reuters Launches Life Sciences Partner Ecosystem to Drive Collaborative R&D Drug Processes 2Treatment to benefit African infants at risk of endemic fever 2
(Date:7/25/2014)... July 26, 2014 "Ischemic Stroke ... 2014" provides data on the Ischemic Stroke and ... elemental information and data relating to the clinical ... View full global Ischemic Stroke Research Report 2014 ... overview of the trial numbers and their recruitment ...
(Date:7/25/2014)... DUBLIN , July 25, 2014 ... of the "Global Metabolomics Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics ... metabolites. Metabolomics has become a new experimental technique ... and the environmental sciences. Metabolites are small molecules ...
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William Pitz ... The World's Most Influential Scientific Minds ." , Westbrook ... were identified by analyzing citation data over the last ... work (2002-2012 and 2012-2013). The two were selected from ... , "This recognition is a great honor for Charlie ...
(Date:7/25/2014)... , July 25, 2014 Sinovac Biotech Ltd. ... products in China , today announced that ... quarter ended June 30, 2014, after market close on Thursday, ... call prior to the market opening on Friday, August 15, ... 8:00 p.m. China Standard Time) to review the Company,s financial ...
Breaking Biology Technology:Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... With employee performance module implemented in just few months, ... ... personal growth, ... of web-based employee performance and talent management software,today announced that ...
... Transave Inc.,reported today that its lead product ... ability to penetrate mucus and,biofilms, and decrease the ... cystic fibrosis, according to results of a study ... of the study titled "Biofilm penetration, triggered release ...
... March 31 Profect(TM) Medical,Technologies, a leading ... clinical photography systems, today announced the introduction ... hiring of Holly Smith as its,Director., ... with an,array of customized photographic and software ...
Cached Biology Technology:Beaumont Hospitals in Michigan Selects Halogen Software for Pay for Performance System 2Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients 2Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients 3Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients 4Holly Smith Joins Profect as Director of Clinical Imaging Services 2
Homo sapiens HCLS1 associated protein X-1 Antigen: Recombinant Protein...
5,6 Carboxyfluorescein is conjugated to BSA (bovine serum albumin) protein through amide bonds....
MOUSE ANTI BOVINE WC1:FITC Immunogen: Bovine lymphocytes...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
Biology Products: