Navigation Links
New test for skin sensitization without using animals

In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers. Their study appears in ACS' journal Chemical Research in Toxicology.

Bruno Miguel Neves and colleagues explain that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. Testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans.

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. Exposure to skin sensitizers triggers characteristic responses, activating genes and making cells release substances that communicate with adjacent cells. Evaluation of the test on 18 compounds showed that it had a sensitivity of 92 percent in correctly identifying actual sensitizers. It had a specificity of 100 percent and did not produce any false positive results indicating that a substance caused sensitization when, in fact, it did not. The approach could be "extremely valuable" in revealing the interaction of skin cells with sensitizers, the scientists say.


Contact: Michael Bernstein
American Chemical Society

Page: 1

Related biology news :

1. Blind flies without recycling
2. A war without end -- with Earths carbon cycle held in the balance
3. Peering into living cells -- without dye nor fluophore
4. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
5. New way to kill lymphoma without chemotherapy
6. Solving puzzles without a picture
7. Not without my microbes
8. Bugs without borders
9. Production of FRP components without release agents
10. How bumblebees find efficient routes without a GPS
11. Surviving without ice
Post Your Comments:
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever ... Duchenne muscular dystrophy (DMD) has provided a new lead ... Children,s Hospital, the Broad Institute of MIT and Harvard ... Brazil . Cell, pinpoints ... dogs "escape" the disease,s effects. The Boston Children,s lab ...
(Date:11/12/2015)... LONDON , Nov. 11, 2015   ... and reliable analytical tools has been paving the ... and qualitative determination of discrete analytes in clinical, ... sensors are being predominantly used in medical applications, ... and environmental sectors due to continuous emphasis on ...
(Date:11/10/2015)... LONDON , Nov. 10, 2015 /PRNewswire/ ... segmented on the basis of product, type, ... segments included in this report are consumables, ... this report are safety biomarkers, efficacy biomarkers, ... in this report are diagnostics development, drug ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
(Date:11/25/2015)... ... 25, 2015 , ... A long-standing partnership between the Academy ... been formalized with the signing of a Memorandum of Understanding. , AMA Executive ... Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, at AMA Headquarters ...
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary Apte, ... their initial angel funding process. Now, they are paying it forward to other ... stage investments in the microbiome space. In this, they join other successful ...
(Date:11/24/2015)... Nov. 24, 2015 Cepheid (NASDAQ: CPHD ... at the following conference, and invited investors to participate ...      Tuesday, December 1, 2015 at 11.00 a.m. ...      Tuesday, December 1, 2015 at 11.00 a.m. ... New York, NY      Tuesday, December ...
Breaking Biology Technology: