Navigation Links
New test for skin sensitization without using animals
Date:3/27/2013

In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers. Their study appears in ACS' journal Chemical Research in Toxicology.

Bruno Miguel Neves and colleagues explain that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. Testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans.

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. Exposure to skin sensitizers triggers characteristic responses, activating genes and making cells release substances that communicate with adjacent cells. Evaluation of the test on 18 compounds showed that it had a sensitivity of 92 percent in correctly identifying actual sensitizers. It had a specificity of 100 percent and did not produce any false positive results indicating that a substance caused sensitization when, in fact, it did not. The approach could be "extremely valuable" in revealing the interaction of skin cells with sensitizers, the scientists say.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Blind flies without recycling
2. A war without end -- with Earths carbon cycle held in the balance
3. Peering into living cells -- without dye nor fluophore
4. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
5. New way to kill lymphoma without chemotherapy
6. Solving puzzles without a picture
7. Not without my microbes
8. Bugs without borders
9. Production of FRP components without release agents
10. How bumblebees find efficient routes without a GPS
11. Surviving without ice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... , ... July 17, 2017 , ... ... characterized by a wide range of overlapping clinical features. The advancement of targeted ... the field of NDD research and testing. , However, designing a custom ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... instruments announced the launch of its new line of Rocking and Waving Shakers ... waving shaker models (both analog and digital) for laboratory applications in a variety ...
(Date:7/14/2017)... ... July 13, 2017 , ... Dr. Joshua Mondlick has introduced the ... his practice, Mondlick Perio, in the Phoenix area. Dr. Mondlick is at ... only FDA cleared laser treatment to re-grow bone and with significantly less pain than ...
(Date:7/13/2017)... ... July 13, 2017 , ... ... Specialty Pharmacy. URAC is the independent leader in promoting healthcare quality through accreditation, ... commitment to quality care, improved processes and better patient outcomes. , ÔÇťAchieving ...
Breaking Biology Technology: