Navigation Links
New test for skin sensitization without using animals
Date:3/27/2013

In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers. Their study appears in ACS' journal Chemical Research in Toxicology.

Bruno Miguel Neves and colleagues explain that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. Testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans.

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. Exposure to skin sensitizers triggers characteristic responses, activating genes and making cells release substances that communicate with adjacent cells. Evaluation of the test on 18 compounds showed that it had a sensitivity of 92 percent in correctly identifying actual sensitizers. It had a specificity of 100 percent and did not produce any false positive results indicating that a substance caused sensitization when, in fact, it did not. The approach could be "extremely valuable" in revealing the interaction of skin cells with sensitizers, the scientists say.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Blind flies without recycling
2. A war without end -- with Earths carbon cycle held in the balance
3. Peering into living cells -- without dye nor fluophore
4. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
5. New way to kill lymphoma without chemotherapy
6. Solving puzzles without a picture
7. Not without my microbes
8. Bugs without borders
9. Production of FRP components without release agents
10. How bumblebees find efficient routes without a GPS
11. Surviving without ice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... researchers, including scientists from the Max Planck Institute for ... major step in understanding photosynthesis, the process by which ... in its atmosphere and which is therefore crucial for ... The researchers report the first direct visualization of a ... in which a specific protein complex, photosystem II, splits ...
(Date:7/11/2014)... Researchers have pioneered a revolutionary new way to ... Virtual Finger, allows scientists to move through digital ... using the flat surface of their computer screens. ... orders of magnitude more efficient, saving time, money ... areas of experimental biology. The software and its ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2A first direct glimpse of photosynthesis in action 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... life one leads, no person has managed to live much ... modern age may have extended the average human life span, ... prominent theory of aging lays the blame on the accumulation ... reactive molecules produced by the metabolic activity of mitochondria. , ...
... compounds, scientists -- and patients -- are getting a ... used in implantable devices to help treat nervous system ... workhorse in implantable devices -- stimulators used to jump ... make critical connections in, for example, Parkinson's and epilepsy ...
... The annual Educational Technology Award of the University of ... 'Virtual microscopy as a teaching aid' of the Biomedical ... utilizes advanced digital imaging and network technology to digitise, ... , 'Virtual specimens' incorporated into educational applications on a ...
Cached Biology News:Carnegie Mellon scientists create PNA molecule with potential to build nanodevices 2New battery technology helps stimulate nerves 2New battery technology helps stimulate nerves 3
(Date:7/10/2014)... may help in the fight against terrorism with the ... of explosives with the use of light and special ... and Actuators B: Chemical , the researchers describe a ... concentrations as low as 6.3 ppm (parts per million). ... minutes. , "Traditionally explosives detection has involved looking for ...
(Date:7/10/2014)... PNAS (Proceedings of the National Academy of Sciences) ... deprivation have a significant effect on our metabolism. The ... time of day to test for diseases such as ... , Researchers from the University of Surrey and The ... sleep deprivation, body clock disruption and metabolism, and discovered ...
(Date:7/10/2014)... observed the fractional quantum Hall effect in bilayer graphene ... be tuned by an electric field. , The ... confined to thin sheets are exposed to large magnetic ... thousands of individual electrons behave as a single system. ... well established, many details of this collective behavior remain ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2
... , , , WHAT: News conference ... for the Warsaw/Kosciusko County community, WHEN: Wednesday, Sept. 23 at ... 200 Seminary Drive Winona Lake, Ind., ... Brad Bishop, Board President, Kosciusko County Community, ...
... SAN FRANCISCO, Sept. 22 A symposium was held last ... Austria entitled "Beta-blockers may now be beneficial in asthma and ... far Inverseon,s asthma program has advanced in the past couple ... and evidence is accumulating that INV102 is showing pre-clinical activity ...
... , DEERFIELD, Ill., Sept. 22 ... annual Astellas Transplant Scholars Awards , $5,000 educational scholarships awarded ... about how transplant affected their education plans, and how they would ... further education and giving back to the transplant community. , ...
Cached Biology Technology:INV102 Asthma Product Discussed at the European Respiratory Society 2Astellas Awards Educational Scholarships to Six Transplant Recipients Who Embody the Spirit of Giving Back 2Astellas Awards Educational Scholarships to Six Transplant Recipients Who Embody the Spirit of Giving Back 3Astellas Awards Educational Scholarships to Six Transplant Recipients Who Embody the Spirit of Giving Back 4
Mouse monoclonal [PRMT5-21] to PRMT5 ( Abpromise for all tested applications). entrezGeneID: 10419 SwissProtID: O14744...
Mouse TrkC Affinity Purified Polyclonal Ab...
Mouse MMP-24 (MT5-MMP) MAb (Clone 143908)...
TMB Slow Kinetic One Component HRP Microwell Substrate, 1 L...
Biology Products: