Navigation Links
New technology to improve early detection and prognosis of cancer
Date:3/24/2011

Grand Rapids, Mich. (March 24, 2011) Gentel Biosciences, a leader in proteomics tools, and Van Andel Research Institute (VARI), a biomedical research institute, jointly announce today the granting of U.S. Patent 7,838,634 for a new method to profile changes in the glycosylation of proteins captured on the surface of an antibody array slide. Gentel first obtained an exclusive right to commercialize the technology in 2006.

According to Brian H. Haab, Ph.D., head of VARI's Laboratory of Cancer Immunodiagnostics and inventor of the technology, "A number of new biomarkers using glycosylated variants of proteins have recently received or are proceeding toward FDA clearance. The ability to efficiently screen glycosylated variants of many proteins for use as biomarkers offers an unprecedented opportunity for discoveries of new glycan-based biomarkers."

Glycosylation is the addition of linear or branched sugar molecules to proteins. Many studies have shown that glycosylated variants of proteins can make better markers for early detection and for prognosis in cancers like hepatocellular carcinoma when compared to measuring the protein alone.

"There is a lack of tools to screen proteins for changes in glycosylation that might be associated with disease. Dr. Haab's approach is a better method to identify new diagnostic biomarkers based on glycosylated variants of proteins," added Bryce P. Nelson, Ph.D., Vice President of Technology and Business Development at Gentel Biosciences.

A patent for the technology is also pending in the European Union.

The new glycan detection technology will soon be combined with the more than fifty SilverQuant Antibody Array kits available from Gentel. These antibody array kits target nearly 500 proteins and provide a complete proteomics workflow from screening to quantification. SilverQuant kits are configured for use with the Gentel Proteomics Multi-System and Gentel's AthenaQuant analysis software for an easy-to-use and cost-effective alternative with better sensitivity than fluorescence-based detection. SilverQuant chromogenic technology allows for the detection of any biotinylated molecule, generating array spots that are visible to the naked eye that can be detected with the Gentel Proteomics Multi-System. Simple protocols empower both experts and novices to obtain meaningful protein multiplexing data in a single day.


'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related biology news :

1. U of M researchers close in on technology for making renewable petroleum
2. University of Houston wins $1 million EPA grant to test diesel technology on buses
3. AMIA on meaningful use: Invest in people and technology
4. Cleveland Clinic researchers honored for contributions to science and technology
5. DHS Science and Technology Directorates science conference: Catastrophes and Complex Systems
6. NextCAT secures license agreement for advanced biofuel technology from Wayne State
7. New technology pinpoints genetic differences between cancer and non-cancer patients
8. Groundbreaking technology will revolutionize blood pressure measurement
9. Stanford researchers develop new technology for cheaper, more efficient solar cells
10. Immunologist J. John Cohen receives the 2010 AAAS Public Understanding of Science and Technology Award
11. New MegaMatcher 4.0 from Neurotechnology Integrates Fingerprint, Iris, Facial and Palmprint Biometrics In One High-Performance SDK
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: