Navigation Links
New technology shows promise against resistant staph infections
Date:4/30/2009

oven difficult. "The problem is that nitric oxide is very short-lived and, until now, methods to deliver it to targeted tissues in the proper dosages have proven elusive," says Dr. Joel Friedman.

The Friedmans solved the problem of controlled and sustained NO delivery by developing a method of generating NO from sodium nitrite within a novel nanoparticle formulation. The nanoparticles are stable when dry and resemble a fine white powder when present in large amounts.

"As the particles take on water, they loosen up and the nitric oxide slowly trickles out, releasing specific amounts of the gas which is exactly what happens in your body," says Dr. Friedman.

The present study involved collaboration between the Friedman laboratory and Dr. Nosanchuk's laboratory. Mice whose skin was infected with methicillin-resistant Staphylococcus aureus, or MRSA, were treated topically with NO-containing nanoparticles or with nanoparticles devoid of NO. A third group received no treatment at all.

The NO-containing nanoparticles proved highly effective. After seven days, infected wounds in the group treated with the NO-containing nanoparticles were significantly improved and smaller than lesions in the two other groups. In addition, bacterial counts were significantly lower in the NO-treated group compared with the other groups, and the NO-treated group showed evidence of accelerated wound healing both visually and microscopically.

After further refining their nanoparticles, the Einstein team plans to test them in clinical trials against MRSA and other infections. Dr. Friedman is confident that the therapy will be safe for human use. "To date there have been no indication of toxicity in any of the numerous animal studies," he says.

In another potential use, Einstein scientists at the annual meeting of the American Urological Association earlier this week reported that nanoparticles carrying either NO or the drug tadalafil (Ciali
'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Yale scientists use nanotechnology to fight E. coli
2. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
3. M2SYS Partners with SecuGen Corporation to Support Market Leading Hamster Plus Fingerprint Reader with Auto-On Technology
4. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
5. Nanotechnology: Whats that?
6. UCs NIH grant brings technology from outer space to playgrounds
7. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
8. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
9. UCLA/VA partners with ASU to advance biosensor technology for urinary tract infections
10. Herr receives Heinz Award for Technology, the Economy and Employment
11. Singapore National Science and Technology Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... When a colony of honeybees grows to about 4,000 ... reproductive cycle: the building of a special type of ... team of experts from the Department of Neurobiology and ... what starts the reproductive cycle of honeybee colonies. The ... The Science of Nature . , Reproduction isn,t ...
(Date:8/19/2014)... be made to decrease China,s increasing caesarean section rate, ... BJOG: An International Journal of Obstetrics and Gynaecology ... caesarean delivery rates in the world. Of 16 million ... Although the exact rate is not known, the current ... total caesarean rates ranging from 36% to 58%. However, ...
(Date:8/19/2014)... lemur. It,s not an African Bush Baby or even a ... downright "cool" primate from Southeast Asia. , "It,s really not ... Brown, curator-in-charge at the University of Kansas, Biodiversity Institute. "A ... body; a long tail with a furry tuft at the ... a bit like the disks on the digits of tree ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3
... DENVER Researchers have linked a variant in the ... chronic obstructive pulmonary disease (COPD) in Caucasian men. The ... Normative Aging Study, a multidisciplinary study of aging that ... presented at the ATS 2011 International Conference. "Our ...
... the process of converting the genetic information encoded in ... protein or any of several types of RNA. Scientists ... different physiological processes throughout the body are robustly pre-determined ... new study by researchers from the University of California, ...
... Most people who have had the experience of having ... the animals can "recognize" us. They seem to recognize our ... they respond to us differently from other people. , Actually, ... shown that domesticated animals, such as honey bees, chickens, pigeons, ...
Cached Biology News:Gene variant linked with development of COPD in men 2Plasticity of hormonal response permits rapid gene expression reprogramming 2I know you, bad guy! 2I know you, bad guy! 3
(Date:8/19/2014)... November 2012, the European Union (EU) mandated use of the ... PSUR – responding to the increasing need to understand and ... in many regions, the main objectives of the PBRER are ... analysis of new or emerging information on the risks of ... the potential benefits of a drug; and , ...
(Date:8/18/2014)... 19, 2014 2014 Deep Research ... a professional and in-depth research report on the ... information, including its definition, classification, application, and ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis. ...
(Date:8/18/2014)... , Aug. 18, 2014   Sterne, Kessler, Goldstein ... in Washington, DC , announced today ... Partes Review (IPR) with the U.S. Patent and ... subsidiary of BioReference Laboratories, Inc. (Nasdaq: BRLI).  These IPR ... licensed by Myriad Genetics, Inc. These patents have been ...
(Date:8/18/2014)... 18, 2014 According to ... By Application (Municipal Wastewater Treatment and Industrial Wastewater ... Multi Tubular), By Configuration (Internal/Submerged and External/Sidestream), and ... MarketsandMarkets, The market for membrane bioreactor systems is ... at a CAGR of 15.28% between 2014 and ...
Breaking Biology Technology:Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 2Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3
... Burn rate significantly reduced and Semen Sexing Technology achieves, ... /PRNewswire-FirstCall/ - For nine months ended June 30, 2009, Microbix ... burn rate. The third quarter had a small sales retraction ... rates. The forecast is for continued growth in sales. , ...
... , , NEWTON, Mass., Aug. 6 ... the Company will release second quarter 2009 financial results on ... markets. , , Michael C. Ferrara, President and ... and Chief Accounting Officer, will host a conference call and live ...
... , PALO ALTO, Calif., Aug. 6 Telik, ... $5.7 million, or $0.11 per share, for the second quarter ended June ... per share, for the comparable period in 2008. , , ... expenses were $6.3 million, compared with $11.0 million in the 2008 second ...
Cached Biology Technology:Microbix Sales Grow 22% For Nine Months 2Microbix Sales Grow 22% For Nine Months 3Microbix Sales Grow 22% For Nine Months 4Microbix Sales Grow 22% For Nine Months 5Microfluidics International Corporation to Report Second Quarter 2009 Financial Results on August 11, 2009 2Telik Announces Second Quarter 2009 Financial Results 2Telik Announces Second Quarter 2009 Financial Results 3Telik Announces Second Quarter 2009 Financial Results 4
Request Info...
Agarose, low melting/gelling temperature, high MW separation (>1000 bp), 25 g. Suitable for enzymatic modifications. Nuclease-free.Gel point: 24-30 C, EEO (-mr): 300 gm/cm2. Category: Nucleotides &...
Request Info...
Request Info...
Biology Products: